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Hormone-Dependent Cancers
Gordon Research Conference

Functional and Clinical Insight in Hormone Dependent Cancers

Dates

August 6-11, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Jason Carroll

Vice Chair:
Steffi Oesterreich

Meeting Description

The Gordon Research Conference (GRC) and the associated Gordon Research Seminar (GRS) on Hormone Dependent Cancer will bring together basic biologists, cancer modellers and clinicians who are focused on understanding hormone dependent cancer and ways of improving the treatment of these diseases.

The major themes will include understanding cancer pathways and processes, how these are corrupted or altered during cancer progression and how novel therapies work mechanistically and what impact cancer perturbations (i.e. mutations) have on the activity of these therapies. In parallel, a major focus will be the development, validation and application of better, more physiologically relevant models for studying hormone dependent cancer and investigation into the role of the tumor microenvironment. A recent advance in the field has been the understanding and exploitation of pathway cross-talk in hormone dependent cancer, which will also compose a part of the conference. Several distinct levels of biology will be represented in this meeting, including the hormones/ligands, the receptors, the downstream transcription factors that mediate the gene expression events and the role of DNA and genetic mutations in this process. Whilst a small part of the meeting will focus on these variables in normal healthy tissue, the bulk of the meeting will address these variables in the context of cancer and the events that go awry during disease development and progression.

Related Meeting

This GRC was held in conjunction with the "Hormone-Dependent Cancers" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Genomic Approaches to Understanding Hormone Dependent Cancer
Discussion Leaders: Geoffrey Greene (University of Chicago, USA) and Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
7:40 pm - 8:20 pmElaine Mardis (Institute for Genomic Medicine, Nationwide Children's Hospital, USA)
"Breast and Endometrial Cancer Genomics: Discovery to Clinic"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmRene Bernards (Netherlands Cancer Institute, The Netherlands)
"Finding Vulnerabilities of Drug-Resistant Cancer"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNuclear Receptor Function and Co-Factors
Discussion Leaders: Qianben Wang (Ohio State University, USA) and Jennifer Richer (University of Colorado Anschutz Medical Campus, USA)
9:00 am - 9:20 amZeynep Madak Erdogan (University of Illinois at Urbana-Champaign, USA)
"Systems Biology of Obesity-Associated ER(+) Breast Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amInez Rogatsky (Hospital for Special Surgery / Weill Cornell Medicine, USA)
"The GR:GRIP1 Axis in Macrophages and Inflammation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amEric Chang (Baylor College of Medicine, USA)
"Direct Regulation of Estrogen Receptor-α Transcriptional Activity by NF1"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amGeorge Muscat (The University of Queensland, Australia)
"Estrogen Signalling Regulates Protein Arginine Methyltransferase 6 Expression in Breast Cancer: Insights into Drug Resistance"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amDonald McDonnell (Duke University, USA)
"Identification of Targetable Proteins and Processes Downstream of Steroid Receptors in Breast and Prostate Cancers"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amStacey Joosten (Netherlands Cancer Institute, The Netherlands)
"Characterizing Steroid Hormone Receptor Overlap in (Fe)male Breast Cancer Tissue"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmIrida Kastrati (University of Illinois at Chicago, USA)
"NFkB Pathway Is a Key Determinant of Tamoxifen Tolerance and Recurrence in Breast Cancer"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAhmed Basudan (University of Pittsburgh, USA)
"ESR1 Copy Number Amplifications and Imbalance in Metastatic Breast Cancer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTumor Microenvironment
Discussion Leaders: Suzanne Conzen (The University of Chicago, USA) and Luke Selth (University of Adelaide, Australia)
7:30 pm - 7:50 pmSenthil Muthuswamy (Beth Israel Deaconess Medical Center / Harvard Medical School, USA)
"Cell Polarity Protein Lethal Giant Larvae in ER+ Breast Cancer"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPepper Schedin (Oregon Health and Science University, USA)
"Normal Mucosal Biology and Tissue Involution Cooperate to Drive Breast Cancer Metastasis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmDavid Lung (McArdle Laboratory of Cancer Research, University of Wisconsin-Madison, USA)
"Bone Marrow Stromal Cell Factors Activate ER Transcriptional Responses Without Requiring ER"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmClaire Nash (Research Institute of the McGill University Health Centre, Canada)
"Genome-Wide Analysis of AR Binding and Transcriptomic Analysis of Primary Prostate Tumour Stroma and Prostate Mesenchyme"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmMatthew Sikora (University of Colorado Anschutz Medical Campus, USA)
"Delineating the ER/WNT4 Signaling Pathway Mediating Proliferation and Survival in Lobular Carcinoma"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFunctional Genomics, Non-Coding RNA and Epigenomics
Discussion Leaders: Felix Feng (University of California, San Francisco, USA) and Charlotte Bevan (Imperial College London, United Kingdom)
9:00 am - 9:20 amMatthew Freedman (Dana-Farber Cancer Institute, USA)
"Identification and Characterization of a Novel Androgen Receptor Enhancer in Advanced Prostate Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRachael Natrajan (The Institute of Cancer Research, London, United Kingdom)
"Alternative Splicing as a Driver of ER+ Breast Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJay Gertz (University of Utah, USA)
"Combinatorial Control of Gene Regulation by Estrogen Receptor Alpha Bound Enhancers"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amLee Kraus (University of Texas Southwestern Medical Center, USA)
"Molecular Mechanisms of Estrogen Signaling in Breast Cancer"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amWilbert Zwart (Netherlands Cancer Institute, The Netherlands)
"Epigenetic Profiling in Prostate Cancer: Classifiers, Biomarkers and Mechanisms"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmClaire Fletcher (Imperial College London, United Kingdom)
"A Novel High-Throughput Screening Approach Identifies Androgen Receptor-Modulatory MicroRNAs and New Therapeutic Targets in Prostate Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmRuth Keri (Case Western Reserve University, USA)
"Targeting Mitosis-Associated Gene Expression in Breast Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMutational Changes in Hormone Dependent Cancer
Discussion Leaders: Sarat Chandarlapaty (Memorial Sloan Kettering Cancer Center, USA) and Scott Dehm (University of Minnesota, USA)
7:30 pm - 7:50 pmAdrian Lee (University of Pittsburgh Cancer Institute, USA)
"Mutational Evolution in Hormone-Independent Breast Cancer"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDoug Levine (Perlmutter Cancer Center, NYU Langone Medical Center, USA)
"Capitalizing on the Mutational Complexity of Gynecologic Tumors"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChris Sweeney (Dana-Farber Cancer Institute, USA)
"Will Biomarkers Lead to Optimal Management of Prostate Cancer?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmRinath Jeselsohn (Dana Farber Cancer Institute, USA)
"Allele-Specific Functions and Therapeutic Vulnerabilities of ESR1 Activating Mutations"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSuzanne Fuqua (Baylor College of Medicine, USA)
"The Y537S ESR1 Mutation Regulates EMT and Is a Metastatic Driver in ER-Positive Breast Cancer"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPathway Cross-Talk
Discussion Leaders: Ganesh Raj (University of Texas Southwestern Medical Center, USA) and Wayne Tilley (University of Adelaide / Hanson Institute, Australia)
9:00 am - 9:20 amKaren Knudsen (Sidney Kimmel Cancer Center, Thomas Jefferson University, USA)
"Targeting Hormone-DNA Repair Crosstalk"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDaniel Frigo (University of Houston, USA)
"Targeting Prostate Cancer Metabolism"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amTheresa Hickey (University of Adelaide, Australia)
"Applying the Endocrine Brakes to Estrogen-Driven Breast Cancers"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amDaniel Gioeli (University of Virginia, USA)
"Take the DDR to the AR to Get Pca"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amCarol Sartorius (University of Colorado Anschutz Medical Campus, USA)
"Mechanisms of Progesterone Receptor Mediated Growth Suppression of Breast Cancer Patient-Derived Xenografts"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmCarol Lange (University of Minnesota, USA)
"Oncogenic Actions of GR-Mediated Stress Signaling in Triple Negative Breast Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmHillary Stires (Georgetown University, USA)
"Androgen Receptor and Endocrine Resistance in Invasive Lobular Breast Carcinoma"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCancer Subtypes
Discussion Leaders: Alex Swarbrick (Garvan Institute of Medical Research, Australia) and Scott Tomlins (University of Michigan, USA)
7:30 pm - 7:50 pmChristina Curtis (Stanford University, USA)
"Learning the Dynamics and Signatures of Treatment Response in Breast Cancer"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJorge Reis-Filho (Memorial Sloan Kettering Cancer Center, USA)
"Molecular Heterogeneity in Breast Cancer Subtypes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMassimo Loda (Dana Farber Cancer Institute / Harvard Medical School, USA)
"Inhibition of De Novo Lipogenesis Suppresses Growth via Modulation of Androgen Receptor Signaling in Castration-Resistant Prostate Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmScott Cramer (University of Colorado, USA)
"Cross-Talk Between Androgen Receptor and CHD1: The REST of the Story"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModelling Cancer and Novel Therapeutics
Discussion Leaders: Elgene Lim (Garvan Institute of Medical Research, Australia) and Saraswati Sukumar (Johns Hopkins University School of Medicine, USA)
9:00 am - 9:20 amRachel Schiff (Baylor College of Medicine, USA)
"The Role of FOXA1 in ER+ Breast Cancer Endocrine Resistance and Metastasis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAlana Welm (University of Utah, USA)
"PDX Models for Breast Cancer"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amAlison Harrod (Imperial College London, United Kingdom)
"Modelling Estrogen Receptor Mutations in Metastatic Breast Cancer"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amCathrin Brisken (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Estrogen Receptor Positive Breast Cancer: How the Microenvironment Matters"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amAlex Gaither (Novartis, USA)
"Novel Clinical Agents for Hormone Dependent Breast Cancer"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmLiz Caldon (Garvan Institute of Medical Research, Australia)
"Polyploidy Is an Early Change in the Acquisition of Endocrine Resistance"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmAlexandra Blee (Mayo Clinic Graduate School of Biomedical Sciences, USA)
"Understanding TMPRSS2-ERG Fusion-Positive Prostate Cancer: Interaction with Gain of Function p53 in Anti-Androgen Resistant Tumors"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Chemistry to Biology and Novel Approaches for Understanding Cancer Biology
Discussion Leaders: Luca Magnani (Imperial College London, United Kingdom) and John Hawse (Mayo Clinic, USA)
5:30 pm - 6:10 pmTimothy Willson (Structural Genomics Consortium, University of North Carolina at Chapel Hill, USA)
"Identification of Small Molecules to Shine Light on Dark Kinases"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 7:00 pmGordon Hager (National Cancer Institute, NIH, USA)
"Chromatin Reprogramming in Breast Cancer"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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