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Autophagy in Stress, Development & Disease
Gordon Research Conference

From the Basics in the Signaling and Molecular Aspect of Autophagy to the Identification of Therapeutic Targets

Dates

March 20-25, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Fulvio Reggiori & Patrice Codogno

Vice Chairs:
Katja Simon & David C. Rubinsztein

Meeting Description

Autophagy is a cellular process that recycles cytoplasmic organelles and other constituents by delivering them to the lysosome for degradation. The past decade has seen an exponential expansion of our knowledge about the regulation and molecular mechanisms of this pathway. Autophagy is tied to stress responses through a number of key signaling pathways, and is orchestrated by a series of core autophagy proteins (ATG proteins) that are evolutionarily conserved. While studies on ATG proteins in mammals and in a multitude of model systems continue to unveil the molecular basis and new facets of the mechanisms underlying autophagy, a series of recent discoveries have revealed the great therapeutic potential that autophagy modulation can have. In particular it has been demonstrated that autophagy and ATG proteins play essential roles in host defense, development, organ and metabolic homeostasis, cancer, inflammation, cardiomyopathies and neurodegeneration.

This Gordon Research Conference will focus on the most up-to-date and innovative science in the field of autophagy, with particular emphasis on the physiological and pathological roles of this pathway, and the potential of translating this new knowledge into therapies. We will begin with presentations on recent findings in the fundamental mechanism of autophagosome biogenesis and the signals responsible for the coordinate regulation of autophagy during stress and development. Subsequently attention will be paid to the function of autophagy in metabolism, ageing and immunity in health as well as disease. Finally, we will cover the most recent advances in the identification of small modulators of autophagy and clinical investigations. We seek to integrate diverse perspectives on the function of autophagy and ATG proteins from the fields of genetics, cell biology, structural biology, system biology, metabolism, development and differentiation, ageing, infection and immunity, drug discovery and clinics.

Related Meeting

This GRC was held in conjunction with the "Autophagy in Stress, Development & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Proteasome and Autophagy: Two Faces of Proteostasis: Implication for Human Disease
Discussion Leader: Patrice Codogno (INSERM, France)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:20 pmFred Goldberg (Harvard Medical School, USA)
"Regulation of Proteasome Function: From Protein Degradation to Disease Therapy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmHerbert Virgin (Washington University School of Medicine, USA)
"Role of Autophagy and Autophagy Genes in Inflammation and Immunity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmTamotsu Yoshimori (Osaka University, Japan)
"Selective Autophagy and Diseases"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMechanism of Autophagy
Discussion Leader: Tamotsu Yoshimori (Osaka University, Japan)
9:00 am - 9:20 amNoboru Mizushima (The University of Tokyo, Japan)
"Initiation of Autophagosome Formation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSharon Tooze (Francis Crick Institute, United Kingdom)
"Trafficking Regulators in Autophagosome Formation"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Liang Ge (University of California, Berkeley, USA)
"Formation of an Endomembrane Compartment for Autophagosome Biogenesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Morel Etienne (Institut Necker Enfants Malades, France)
"Autophagosome Biogenesis at Endoplasmic Reticulum-Plasma Membrane Contact Sites"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amHitoshi Nakatogawa (Tokyo Institute of Technology, Japan)
"Molecular Mechanisms of ER-Phagy and Nucleophagy in Yeast"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJames Hurley (University of California, Berkeley, USA)
"Structural Insights into Autophagy Initiation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Vladimir Rogov (Institute of Biophysical Chemistry, University of Frankfurt, Germany)
"Autophagy Meets Ufmylation at the Novel Ubiquitin-Like Protein-Binding Motif LIR/UFIM, Which Is Located Within the UBA5 C-Terminal Region and Required for Its Function"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Jayanta Debnath (University of California, San Francisco, USA)
"Proximity-Specific Biotinylation Identifies New Targets of Autophagy-Dependent Secretion"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sharon Tooze (Francis Crick Institute, United Kingdom) and Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of Autophagy
Discussion Leader: David Rubinsztein (University of Cambridge, United Kingdom)
7:30 pm - 7:50 pmKun-Liang Guan (University of California, San Diego, USA)
"Nutrient Signaling in Cell Growth Control"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAdi Kimchi (Weizmann Institute of Science, Israel)
"Phosphorylation Events Regulating the Function of Autophagic Proteins"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmIvan Dikic (Goethe University Medical School, Germany)
"Ubiquitin Regulation of Selective Autophagy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Douglas Grunwald (University of Minnesota Twin Cities, USA)
"Role of the ULK1 Complex-Atg8 Interaction in Autophagy"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Prasun Guha (Johns Hopkins School of Medicine, USA)
"Inositol Polyphosphate Multikinase Is a Critical Regulator of Autophagy"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAutophagy in Model Organisms and Plants
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:20 amEric Baehrecke (University of Massachusetts Medical School, USA)
"Autophagy, Cell Health and Cell Death"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHong Zhang (Chinese Academy of Sciences, China)
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Nobuo Noda (Microbial Chemistry Research Foundation, Institute of Microbial Chemistry, Japan)
"Structural Basis of the Autophagy Initiating PAS Assembly"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Christine Abert (Max F. Perutz Laboratories, University of Vienna, Austria)
"Multiple Atg8 Binding Sites in the Atg19 Receptor Are Crucial for Selective Autophagy"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDiane Bassham (Iowa State University, USA)
"rRNA Turnover in the Plant Vacuole via Autophagy"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMiguel Penalva (Centro de Investigaciones Biológicas (CIB), Spain)
"Autophagy in Aspergillus nidulans: What Can We Learn from a Filamentous Fungus?"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Christian Ungermann (University of Osnabrück, Germany)
"Insights into Autophagosome-Vacuole Fusion"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Andreas Jenny (Albert Einstein College of Medicine, USA)
"Selective Endosomal Microautophagy Is Starvation Inducible in Drosophila"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAutophagy in Infection and Immunity
Discussion Leader: Herbert Virgin (Washington University School of Medicine, USA)
7:30 pm - 7:50 pmKen Cadwell (New York University School of Medicine, USA)
"Atg16L1 and Host-Pathogen Interactions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmVojo Deretic (University of New Mexico Health Sciences Center, USA)
"Precision Autophagy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChristian Munz (University of Zurich, Switzerland)
"Non-Canonical Roles of Autophagy Proteins in Endocytosis and Exocytosis During Infections"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Philippe Pierre (CNRS, France)
"Autophagy Regulation in Immune Cell Subsets, a Focus on RUFY4"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Yair Botbol (Albert Einstein College of Medicine, USA)
"Common Gamma-Chain Cytokine Signaling Is Critical for Activation-Induced Autophagy in CD4+ T Cell"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAutophagy in Development and Differentiation
Discussion Leader: Ana Maria Cuervo (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 amBeth Levine (University of Texas, USA)
"Inner Mitochondrial Membrane Proteins Involved in Mitophagy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAndrea Ballabio (Telethon Institute of Genetics and Medicine, Italy)
"Lysosomal Signalling Controls Autophagy"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Fiona Menzies (University of Cambridge, United Kingdom)
"Autophagy Regulation of Notch Degradation and Its Functional Consequences"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Flavie Strappazzon (Santa Lucia Foundation, Italy)
"Pro-Survival AMBRA1 Turns into a Pro-Apoptotic BH3-Like Protein During Mitochondrial Apoptosis"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amLi Yu (Tsinghua University, China)
"Assembly of Multi-Kinases Complex on Mitochondria Initiate Energy Deprivation Induced Autophagy"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAugustine Choi (Weill Cornell Medical College, USA)
"Crosstalk Between Autophagy and Inflammation and Cell Death"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Thomas Riffelmacher (University of Oxford, United Kingdom)
"Autophagy Is Essential for Neutrophil Differentiation - Guiding a Metabolic Switch"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Jingyu Yao (University of Michigan, USA)
"Autophagy-Mediated Catabolism of Visual Transduction Proteins Prevents Retinal Degeneration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAutophagy in Metabolism and Ageing
Discussion Leader: Vojo Deretic (University of New Mexico Health Sciences Center, USA)
7:30 pm - 7:50 pmAna Maria Cuervo (Albert Einstein College of Medicine, USA)
"Selective Autophagy: Helping to Make the Right Metabolic Choices"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmGuido Kroemer (University of Paris Descartes, France)
"Caloric Restriction Mimetics for Autophagy Induction - From Theory to Clinical Implementation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMalene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Autophagy and Aging: Lessons from Long-Lived Animals"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Nunzia Pastore (Baylor College of Medicine, USA)
"TFEB and TFE3 Cooperate in the Control of Lipid Metabolism"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmGisela Otten (Newcastle University, United Kingdom)
"Oxidation-Dependent Regulation of the Autophagy Receptor Sqstm1/p62 and Its Potential Role in Amyotrophic Lateral Sclerosis (ALS)"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmAutophagy in Diseases
Discussion Leader: Katja Simon (University of Oxford, United Kingdom)
9:00 am - 9:20 amAlec Kimmelman (Dana Farber Cancer Institute, Harvard University, USA)
"Autophagy, Metabolism, and Pancreatic Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMihai Netea (Radboud University Nijmegen Medical Centre, The Netherlands)
"Autophagy Control of Cytokines and Inflammatory Processes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Rhea Sumpter (University of Texas Southwestern Medical Center, USA)
"Fanconi Anemia Tumor Suppressor Genes Function in Selective Autophagy, Immunity and Mitochondrial Homeostasis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Sergio Catz (The Scripps Research Institute, USA)
"Improvement of Cellular Function in Cystinosis by Modulation of Chaperone-Mediated Autophagy and LAMP2A Trafficking"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMondira Kundu (St. Jude Children's Research Hospital, USA)
"Ulk1/Atg1 in Development and Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCharleen Chu (University of Pittsburgh, USA)
"Regulation of Injury-Induced Mitophagy: Day Jobs and Emergency Call"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Natalia Kononenko (CECAD, University of Cologne, Germany)
"Autophagosome Transport via the Endocytic Adaptor AP-2 Mediates Neuronal Complexity and Prevents Neurodegeneration"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Wei-Xing Zong (Rutgers University, USA)
"p62 Ubiquitylation in Protein Aggregation and Redox Homeostasis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDrug Discovery and Potential Therapeutic Targets
Discussion Leader: Beth Levine (University of Texas, USA)
7:30 pm - 7:50 pmBeat Nyfeler (Novartis Institutes for BioMedical Research, Switzerland)
"Autophagy: A Therapeutic Target for Cancer?"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJunying Yuan (Harvard Medical School, USA)
"Regulation of Type III PI3 Kinase in Control of Autophagy"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJanice Lee (Takeda Oncology, USA)
"Targeting Autophagy for Cancer Therapy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Zhe Sha (Harvard Medical School, USA)
"Proteasome Inhibition Causes Selective Induction of p62 and GABARAPL1, Which Promote the Clearance of Ubiquitin Conjugates via an Autophagy-Independent Mechanism"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Maged Harraz (The Johns Hopkins University, USA)
"Autophagy Mediates Neurotoxic and Stimulant Effects of Cocaine"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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