SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Harnessing Biology to Optimize Radiation Therapy |
| Discussion Leader: Bill Morgan (Pacific Northwest National Laboratory) |
7:40 pm - 8:25 pm | Dennis Hallahan (Washington University School of Medicine) "Radiation Used to Guide Nanoparticle Drug Delivery to the Tumor" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Joe Gray (Lawrence Berkeley National Laboratory) "Translating Insights from the Cancer Genome into Clinical Practice" |
9:20 pm - 9:30 pm | Discussion |
9:30 pm | Chairs Welcome Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Targeting the DNA Damage Response for Cancer Therapy |
| Discussion Leader: Simon Powell (Memorial Sloan Kettering Cancer Center) |
9:00 am - 9:25 am | Mark O’Connor (KuDOS Pharmaceuticals) "Combining Inhibitors of DNA Damaging Response with Ionizing Radiation: Opportunities and Challenges" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Sharon Cantor (University of Massachusetts Medical School) "Targeting the BRCA 1-Associated FANCJ in Cancer" |
10:05 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:15 am | David Kirsch (Duke University) "Using Mouse Genetics to Study Mechanisms of Acute Radiation Injury" |
11:15 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Conchita Vens (Netherlands Cancer Institute) "Targeted Radiosensitization of BER Deficient Cells" |
11:55 am - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Simon Powell’s choice from abstracts |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modulating Radiation Sensitivity by Perturbing Receptor Signaling Pathaways |
| Discussion Leader: Marianne Sowa (Pacific Northwest National Laboratory) |
7:30 pm - 7:55 pm | Garth Powis (MD Anderson Cancer Center) "Radiation Therapy and Hypoxia Signaling" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Daphne Haas-Kogan (University of California, San Francisco) "Incorporation of PI3-Kinase Inhibitors into Multi-modality Therapy" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Costas Koumenis (University of Pennsylvania School of Medicine, Philadelphia) "Thoredoxin Reductase 1 as a Radiosensitization Target of the Clinically Used Polyphenolic Curcumin" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Marianne Sowa's choice from abstracts |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Custom Tailoring Radiation Therapy Based on Individual Susceptibilities |
| Discussion Leader: Bill McBride (University of California, Los Angeles) |
9:00 am - 9:25 am | Quynh-Thu Le (Stanford University) "Where are we in Targeting the Tumor Microenvironment in Solid Cancers?" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Kian Ang (MD Anderson Cancer Center) "We are Making Progress in Personalizing Cancer Radiotherapy?" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Marcel Verheij (Netherlands Cancer Institute) "Combining Radiation with Death Receptor Ligands" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Gillies McKenna (Oxford University) "Conditioning Tumors for Cytotoxic Therapy" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Bill Morgan’s choice from abstracts |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systemic Responses to Radiation that Impact Therapy |
| Discussion Leader: Mary Helen Barcellos (New York University) |
7:30 pm - 7:55 pm | Lynn Hlatky (Tufts University) "Dormancy, Angiogenic Switch and Radiation" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Andrei V. Gudkov (Roswell Park Cancer Institute) "Dissection, Integration and Pharmacological Modulation of Different Components of Acute Radiation Syndrome" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Katrina Waters (Pacific Northwest National Laboratory) "Data Integration for Cell Stress Responses after Irradiation" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Mary Helen Barcellos (New York University) "Systemic Responses to Radiation that Impact Therapy" |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Poster Session |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Application of New Modalities/Technologies in Radiation Oncology |
| Discussion Leader: Richard Kolesnick (Memorial Sloan Kettering Cancer Center) |
9:00 am - 9:25 am | Chuan-Yuan Li (University of Colorado) "The Interplay between Cellular Life and Death During Radiotherapy" |
9:25 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Zvi Fuks (Memorial Sloan Kettering Cancer Center) "Biological Basis of Single Dose Radiotherapy" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Robert (Bob) Timmerman (University of Texas, Southwestern) "Clinical Applications of High Dose Hypofractionated Radiotherapy" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Ritsuko Komaki (MD Anderson Cancer Center) "Proton Beam Treatment Reduced Normal Tissue Toxicity for Patients with Locally Advanced Non-small Cell Lung Cancer Treated by Concurrent Chemotherapy" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Richard Kolesnick’s choice from abstracts |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | The Pros and Cons of Stem Cells in Radiotherapy |
| Discussion Leader: Charlie Limoli (University of California, Irvine) |
7:30 pm - 7:55 pm | Wendy Woodward (MD Anderson Cancer Center) "Radiation Resistance of Breast Cancer Stem Cells" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Frank Pajonk (University of California, Los Angeles) "Radiation Resistance of Cancer Stem Cells - Mechanisms and Implications" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Joel S. Greenberger (University of Pittsburgh Medical Center) "Mitochondrial Targets for Normal Tissue Radioprotection" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Charlie Limoli’s choice from abstracts |
9:25 pm - 9:30 pm | Discussion |
9:30 pm - 11:30 pm | Poster Session |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Anti-angiogenesis and Radiation Therapy |
| Discussion Leader: Amato Giaccia (Stanford University) |
9:00 am - 9:25 am | Denise Chen (Stanford University) "Hydroxylation and the Tumor Microenvironment" |
9:25 am - 9:40 am | Discussion |
9:40 am -10:05 am | Chris Willet (Duke University) "Integration of Target Agents with Radiation Therapy and Chemotherapy in Localized Gastrointestinal Malignancies" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Adam P. Dicker (Thomas Jefferson University) "Integration of Antiangiogenic Agents in Radiation Oncology; Bridging the Gap Between the Lab and Clinic" |
11:05 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Philip Hahnfeldt (Tufts University School of Medicine) "Metronomic Antiangiogenic Therapy - What is it and How does it Work?" |
11:45 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Amato Giaccia’s choice from abstracts |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Open Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Clinical Application of Nanotechnologies in Radiation Therapy |
| Discussion Leader: Gayle Woloschak (Northwestern University Medical Center) |
7:30 pm - 7:55 pm | Mohamed Khan (Roswell Park Memorial Institute) "The Use of Nanocomposites for Cancer Imaging and Therapy" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Nicola R. Sibson (Oxford University) "Molecular MRI: A New Tool for Metastasis Detection" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | David Boothman (University of Texas Southwestern Medical Center) "Nanoparticle-Delivered ‘Kiss of Death’: β- Lapachone, a Novel-Radiosensitizing Agent NQO1/xip3-Oversexpressing Cancer" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Gayle Woloschak’s choice from abstracts |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |