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Chemical & Biological Terrorism Defense
Gordon Research Conference

Innovation and Advancement: Fundamental Science Resulting in Next-Gen Solutions for Chemical and Biological Threats

Dates

March 5-10, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Steven R. Blanke

Vice Chairs:
Catharine M. Bosio & Patrick M. McNutt

Meeting Description

The 2017 Gordon Research Conference (GRC) "Chemical and Biological Terrorism Defense" and its companion Gordon Research Seminar (GRS), will showcase exciting, innovative basic and translational research in the areas of biological and chemical threat agents, underscored by myriad opportunities for intensive discussion and networking between young and seasoned researchers from academia, government, medicine and biotech. This biennial international conference continues to be regarded by the biological and chemical defense communities as a premier venue for intellectual exchange and cross-disciplinary fertilization. To be held March 4-10 at the Ventura Marriott in Ventura California, the 2017 conference is led by Chair Steven Blanke, Ph.D., and Vice Chairs Catharine Bosio, Ph.D. and Patrick McNutt, Ph.D. Each scientific session will be crafted to highlight and engender themes and solutions common to both the chemical and biological threat communities. These, nine sessions will feature 32 invited speakers plus 4 young investigators/trainees that will be selected from the GRS, chosen to integrate cutting-edge research on: mechanisms, sources, and treatment of biological and chemical threats; the threat of non-human targets to human health disease; translational approaches for countermeasures and prevention; and cross-disciplinary solutions to detection and decontamination. Emerging issues of scientific and security importance, such as gene drives, and, new smart detection devices, will be featured. Poster sessions will promote extended discussions between investigators within and across disciplines and ranks. To integrate and develop the next generation of scientists in our field, the GRC will be preceded by a GRS. Together the Seminar and Conference promise to provide an exceptional forum for a diverse population of scientists to learn about cutting edge discoveries in the field, and consider and challenge the current paradigms, barriers and opportunities to advancing knowledge in the areas of defenses against chemical and biological threat agents.

Related Meeting

This GRC was held in conjunction with the "Chemical & Biological Terrorism Defense" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Ever Changing Landscape of Threats to Human Health and Security
Discussion Leader: Steven Blanke (University of Illinois, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:15 pmArik Eisenkraft (Institute for Research in Military Medicine, Hebrew University of Jerusalem, Israel)
"OP or Not OP, that Is the Question"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmOwain Edwards (CSIRO Land and Water, Australia)
"How Concerned Should We Be About Gene Drive Technologies?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAdam Ruben (Johns Hopkins University, USA)
"Public Perception of Chemical and Biological Terrorism"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeural Dysfunction: Mechanisms, Detection, and Countermeasures
Discussion Leader: John McDonough (U.S. Army Medical Research Institute of Chemical Defense, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader: Introduction and Perspectives on Emerging Issues and Innovative Solutions for Threat Agents Targeting Neural Function
9:15 am - 9:45 amDouglas Cerasoli (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Using Novel Enzymes to Protect Against Organophosphorus Toxicity"
9:45 am - 9:55 amDiscussion
9:55 am - 10:15 amEdwin Vazquez-Cintron (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Intraneuronal Delivery of Single Domain Antibodies for Treatment of Post-Symptomatic Botulism"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:25 amAndrew Pickett (Toxin Science Limited, United Kingdom)
"Botulinum Toxin - From Biothreat to Biomedicine"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmPamela Lein (University of California, Davis, USA)
"A Tale of Two Threat Agents: OPs and TETS"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Molly Hughes (University of Virginia, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHost Interactions and Responses
Discussion Leader: Manuela Raffatellu (University of California, Irvine, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Introduction and Perspectives on Host Immunity and Threat Agents
7:45 pm - 8:10 pmWyndham Lathem (Institut Pasteur, France)
"Your Own Worst Enemy: How Yersinia pestis Turns the Body Against Itself"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmAlexis Kaushansky (Center for Infectious Disease Research, USA)
"Combining Mechanistic and Global Insights to Identify Critical Interactions Between Pathogen and Host"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmTimothy Sampson (California Institute of Technology, USA)
"Alternative Roles for CRISPR-Cas Systems in Bacterial Pathogenesis"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmHost Barrier Function and Dysfunction
Discussion Leader: Carolyn Coyne (University of Pittsburgh, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader: Overview and Perspectives on the Host Barriers, and How Biological and Chemical Threat Agents Might Affect Barrier Function
9:15 am - 9:45 amDebra Laskin (Rutgers University, USA)
"Inflammatory Mechanisms of Lung Injury Induced by Mustard Vesicants"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amHarald Ott (Harvard Medical School, Massachusetts General Hospital, USA)
"Rebuilding the Damaged Lung"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amWilliam Beavers (Vanderbilt University, USA)
"Imaging Mass Spectrometry: Untargeted Molecular Histology at the Host-Pathogen Interface"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmCarolyn Coyne (University of Pittsburgh, USA)
"Antimicrobial Signaling at the Maternal-Fetal Interface"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTargeting Metabolism
Discussion Leader: Catharine Bosio (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Overview and Perspectives on the the Targeting of Metabolism by Threat Agents
7:45 pm - 8:10 pmJean Challacombe (Los Alamos National Laboratory, USA)
"Metabolic Targets: Modeling and Predictions"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmGahl Levy (The Hebrew University of Jerusalem, Israel)
"Nuclear Receptors Control Pro-Viral and Antiviral Metabolic Responses to Hepatitis C Virus Infection"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMichael Lagunoff (University of Washington, USA)
"Targeting Viruses Through Cellular Metabolism"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExtended and Emerging Threats to Human Health and Security
Discussion Leader: Katrina Campbell (Queen's University Belfast, United Kingdom)
9:00 am - 9:15 amIntroduction by Discussion Leader: Perspectives and Overviews on Extended and Emerging Threats to Human Health and Security
9:15 am - 9:45 amWilliam Schneider (Foreign Disease Program, Agricultural Research Service, USDA, USA)
"CRISPR/Gene Grives: Potential Threats in Plants and Agriculture"
9:45 am - 9:55 amDiscussion
9:55 am - 10:25 amTownsend Peterson (University of Kansas, USA)
"From WMDs to CMBs: What Creative Malicious Biologists Could Do, but Haven't"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amCorey Hudson (Sandia National Laboratories, USA)
"Building Cyberthreat Models for Genomic Security"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmTrevor Bedford (Fred Hutchinson Cancer Research Center, USA)
"Real-Time Genomic Surveillance of Pathogen Evolution and Spread"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLooking Ahead: Young Investigator Presentations / Alternative Approaches
Discussion Leader: Thomas Blake (Centers for Disease Control and Prevention, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader: Perspectives on Emerging Threats and Challenges: A Perspective from the CDC
7:40 pm - 7:55 pmRamin Hakami (George Mason University, USA)
"The Art of War: Exosomes as Carrier Pigeons of the Cell to Protect from Bacterial Spread During Infection with Yersinia pestis"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmHilary McCarren (U.S. Army Medical Research Institute of Chemical Defense, USA)
"Combined Stimulation of a2-Adrenoceptors and GABAA Receptors Abruptly Terminates Soman-Induced Status Epilepticus"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmDavid Franz (NGI, USA)
"Powerful Science: A Tool of Diplomacy"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmDebobrato Das (University of Washington, USA)
"Engineering Inhalable Polymeric Prodrugs of Ciprofloxacin for Prophylactic andTherapeutic Treatment of Highly-Lethal Pulmonary Francisella tularensis Infections"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmRobin Holland (University of Illinois at Urbana Champaign, USA)
"Activating Mitochondrial Quality Control as a Strategy to Combat Mitochondrial Targeted Pathogenic Effectors"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSmart Approaches for Detection, Prevention, and Intervention
Discussion Leader: Patrick McNutt (U.S. Army Medical Research Institute of Chemical Defense, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader: The Emergence of Smart Solutions to Threat Agents
9:15 am - 9:40 amEsther Chang (Georgetown University, USA)
"A Platform Technology Based on a Nanocomplex that Actively Crosses the Blood-Brain Barrier and Its Use in Medical Countermeasures Against Both Chemical and Biological Threat Agents"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amCharles Thompson (University of Montana, USA)
"Interrogation of In Vivo Modes of Action of Positron-Labeled Organophosphates and Antidotes with Dynamic PET Imaging"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amRobert Meagher (Sandia National Laboratories, USA)
"You Catch More Flies (and Mosquitoes) with Honey - A New Approach to Automating Surveillance for Arboviruses"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmPaula Hammond (Massachusetts Institute of Technology, USA)
"Nanolayered Delivery from Trauma: Delivery Solutions for Field Care Medicine"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmWorking at the Periphery: Bioengineering-Inspired Solutions for Counteracting Biological and Chemical Threats
Discussion Leader: Patrick Stayton (University of Washington, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader: Perspectives and Overview of the Capacity of Bioengineering to Meet the Challenges and Opportunities Associated with Existing and Emerging Threats
7:45 pm - 8:10 pmNicole Steinmetz (Case Western Reserve University, USA)
"Plant Virus-Based Nanotechnologies"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmBernhard Weigl (Global Good, Intellectual Ventures, USA)
"High Performance Lateral Flow Assays as First Line of Defense Against Bioagents"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDaniel Fletcher (University of California, Berkeley, USA)
"Dial 'P' for Pathogen"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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