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Mechanisms of Epilepsy & Neuronal Synchronization
Gordon Research Conference

Aberrant Circuits to Impaired Function in Epilepsy

Dates

August 21-26, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chairs:
Steve C. Danzer & Heinz W. Beck

Vice Chairs:
Christophe Bernard & Amy Brooks-Kayal

Meeting Description

The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks – in order to develop more effective treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy is that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon Research Conference is to bring together geneticists, molecular biologists, developmental neuroscientists, translational researchers/clinicians, neuroanatomists, electrophysiologists and computational neuroscientists working on basic mechanisms related either directly or indirectly to the generation of synchronous activity, including seizures. In particular, the conference will feature novel and transformative approaches and tools that are highly relevant to dissecting the functional anatomy of neuronal circuits in intact animals. We believe that discussing these novel approaches in the context of neuronal synchronization and epilepsy is timely, and will set the stage for future discoveries.

The program's theme is "Aberrant Circuits to Impaired Function in Epilepsy". The focus will be on examining the disruptive effects epilepsy has on brain development and function. Sessions are organized in a bottom-up fashion, with early sessions focusing on changes at the cellular and microcircuit levels while later sessions focus on higher order cognitive functions and comorbidities. The final session will focus on strategies to prevent and repair epileptogenic brain changes.

Our goals are to disseminate the latest scientific advances, to foster productive new insights and collaborations, to stimulate an interest in epilepsy research among young investigators and to set the stage for new translational studies that will bring the latest discoveries to the treatment of epilepsy in the shortest possible time.

Related Meeting

This GRC was held in conjunction with the "Mechanisms of Epilepsy & Neuronal Synchronization" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Network Function in the Normal and Diseased Brain
Discussion Leaders: Heinz Beck (University of Bonn Medical Center, Germany) and Steve Danzer (Cincinnati Children's Hospital Medical Center, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmGabor Tamas (University of Szeged, Hungary)
"Similarities and Differences of Human and Rodent Synapses, Neurons and Networks in the Neocortex"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmYehezkel Ben-Ari (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France)
"Treating Autism Beyond Genes and Psychiatry. Is Delivery a Critical Period for the Pathogenesis of Autism?"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNetwork Dysfunction in Genetic Epilepsies
Discussion Leader: Jeffrey Noebels (Baylor College of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDirk Isbrandt (German Center for Neurodegenerative Diseases (DZNE), Germany)
"Timed Treatments During Vulnerable Developmental Periods for Prevention of Epileptogenesis in Mouse Channelopathies"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMichael Wong (Washington University in St. Louis, USA)
"Cell-Specific Contributions to Epileptogenesis in Tuberous Sclerosis: Neurons and Astrocytes and Microglia! Oh My!"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amChristina Gross (Cincinnati Children's Hospital Medical Center, USA)
"MicroRNA-Mediated Regulation of the Potassium Channel Kv4.2 During Seizures"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amHolger Lerche (Hertie Institute for Clinical Brain Research / University of Tübingen, Germany)
"Novel Genetic Defects in Epilepsy and Therapeutic Implications"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmYpe Elgersma (Erasmus University, The Netherlands)
"Mechanisms Underlying mTOR-Mediated Epilepsy in a Mouse Model of TSC"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAngel Lopez (Baylor College of Medicine, USA)
"AnkG Isoform Imblance and Interneuronopathy Link Epilepsy and Bipolar Disorder"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Candi LaSarge (Cincinnati Children's Hospital Medical Center, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRegulation and Mis-Regulation of Neuronal Circuit Development
Discussion Leader: Kevin Staley (Harvard Medical School, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmJack Parent (University of Michigan, USA)
"Combining Human Cell and Rodent Models to Decipher Epileptic Encephalopathies"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAlbert Becker (University of Bonn, Germany)
"Loss of STE-20 Like Kinase as Emergent in Human Epileptogenic Malformations Impairs High-Order Dendrite Arborization and Inhibitory Synapse Maintenance"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmPierre-Pascal Lenck-Santini (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France)
"Network Dynamics in Normal vs. Epileptic Brain"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRegulation of Neuronal Circuits by Astrocytes
Discussion Leader: Karen Wilcox (University of Utah, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amChristian Henneberger (University of Bonn Medical School, Germany)
"Rapid Astrocyte Morphology Changes During Epileptogenesis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amNicola Allen (Salk Institute for Biological Studies, USA)
"Astrocyte Regulation of Synaptic Glutamate Receptors"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amLauren Lau (Tufts University, USA)
"Targeting Alpha-2-Delta-1 Prevents Pathological Synaptogenesis and Cell Death Following Neonatal Cortical Insult"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amCatherine Christian (University of Illinois at Urbana-Champaign, USA)
"Bidirectional Astrocytic Modulation of GABAAR-Mediated Synaptic Transmission"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmNathalie Rouach (Collège de France, France)
"Unraveling the Role of Astroglial Networks in Neuronal Coordination"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmFrances Cho (Gladstone Institutes, University of California, San Francisco, USA)
"Selective Astrogliosis Increases Thalamic Circuit Excitability and Oscillations"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGABAergic Circuit Function and Neuronal Oscillations
Discussion Leader: Douglas Coulter (Children's Hospital of Philadelphia, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmScott Baraban (University of California, San Francisco, USA)
"Functional Integration of GABA Progenitor Cells in Host Circuits"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmIlan Lampl (Weizmann Institute of Science, Israel)
"A Novel Chemo-Optogenetic Model of Focal Epilepsy"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmLaura Colgin (University of Texas at Austin, USA)
"Slow and Fast Gamma Oscillations in the Hippocampus"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNormal Circuit Function in Cognition
Discussion Leader: Ivan Soltesz (Stanford University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amCarol Barnes (University of Arizona, USA)
"Memory Circuits in Normal Aging: Excitability and Adaptation"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amAnton Sirota (Ludwig Maximilian University of Munich, Germany)
"Anatomical Perspective on High-Frequency Oscillations in the LFP"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amJiadong Chen (University of California, San Francisco, USA)
"Novel GABAergic Long-Range Projection in Cortical Development and Disease"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amFlorian Mormann (University of Bonn, Germany)
"Single Neuron Correlates of Perception and Memory in the Human Medial Temporal Lobe"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmUeli Rutishauser (Cedars-Sinai Medical Center, USA)
"The Microcircuits of Human Declarative Memory: The Role of Theta-Mediated Coordination"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMichael Wenzel (Columbia University, USA)
"In Vivo Population Imaging of Seizure Progression Within and Across Cortical Layers"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPathological Circuit Function in Epilepsy
Discussion Leader: Viji Santhakumar (Rutgers New Jersey Medical School, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmValerie Crepel (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France)
"Pathophysiology of Temporal Lobe Epilepsy: Role of Ectopic Kainate Receptors"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmPeyman Golshani (University of California, Los Angeles, USA)
"Dentate Gyrus Interneuron Desynchronization in Epilepsy"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmLiset Menendez de la Prida (Cajal Institute, Spanish National Research Council (CSIC), Spain)
"Common Circuits of Hippocampal Rhythmopathies in Temporal Lobe Epilepsy"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCircuit Dysfunction in Epilepsy Comorbidities
Discussion Leader: Nigel Jones (University of Melbourne, Australia)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amLennart Mucke (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA)
"Overlapping Mechanisms and Therapeutic Opportunities in Epilepsy and Alzheimer's Disease"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amJamie Maguire (Tufts University School of Medicine, USA)
"Seizure-Induced Plasticity in the GABAergic Control of the HPA Axis: Relevance to Comorbid Depression"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amAynara Wulsin (Cincinnati Children's Hospital Medical Center, USA)
"Glucocorticoid Receptor Inhibition as a Novel Treatment for Epilepsy"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amTallie Z. Baram (University of California, Irvine, USA)
"Circuit and Cellular Dysfunction Contribute to Cognitive Impairment After Febrile Status Epilepticus"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmLaura Cancedda (Italian Institute of Technology, Italy)
"Protocadherin 19 Downregulation Affects Hippocampal Development and Increases Seizure Susceptibility in Rats"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJulia Kahn (University of Pennsylvania, USA)
"Epilepsy-Associated Dentate Granule Cell Hyperactivity Critically Contributes to Cognitive Comorbidities"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmUsing Circuit-Level Insights to Repair and Manipulate the Epileptic Brain
Discussion Leader: Istvan Mody (David Geffen School of Medicine, University of California, Los Angeles, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmEsther Krook-Magnuson (University of Minnesota, USA)
"Optogenetic Dissection of Circuits in Temporal Lobe Epilepsy"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmJeanne Paz (Gladstone Institutes, University of California, San Francisco, USA)
"Bi-Directional Control of Seizures by the Thalamus: Dravet Syndrome"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmLuke Lavis (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"From Drugs to Dyes and Back Again"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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