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Biology of Acute Respiratory Infection
Gordon Research Conference

Host-Pathogen Interactions in Acute Respiratory Tract Infection: From Basic Mechanisms to Human Disease

Dates

February 21-26, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Theodore J. Standiford & Peter Openshaw

Vice Chairs:
Chad Steele & Dawn Bowdish

Meeting Description

Acute respiratory tract infections account for substantial morbidity and mortality worldwide. The changing demographics of the population at risk, combined with the emergence of new and resistant microbial pathogens suggest that the burden of disease will almost certainly worsen. The 2016 Gordon Research Conference (GRC) on Biology of Acute Respiratory Tract Infection will highlight new paradigms in lung infection, including novel insights into pathogen recognition and cellular participants involved, antimicrobial effector mechanisms, regulation of lung injury and repair in respiratory infection, the development of lung immune memory, mechanisms of microbial pathogenesis, the lung microbiome in health and disease, emerging respiratory pathogens, genetic and environmental regulation of the host response, and strategies for the prevention, treatment, and profiling of the host response in patients with acute respiratory tract infections. An international group of experts have been assembled to provide cutting-edge overviews of these rapidly evolving fields. The GRC on Biology of Acute Respiratory Tract Infection provides an ideal venue for the creative and dynamic exchange between a multidisciplinary group of basic biologists, translational scientists, and clinical investigators. A fundamental understanding of basic mechanisms involved will foster the development of innovative approaches to the diagnosis, prevention and treatment of serious infections of the respiratory tract.

Related Meeting

This GRC was held in conjunction with the "Biology of Acute Respiratory Infection" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPathogen Recognition and Cellular Participants in Lung Immunity: Novel Mechanisms
Discussion Leader: Chad Steele (University of Alabama at Birmingham, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmBart Lambrecht (Ghent University - VIB, Belgium)
"Dendritic Cell Subsets in Respiratory Viral Infection"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmSamithamby Jeyaseelan (Louisiana State University, USA)
"Nod Like Receptors in Bacterial Lung Infection"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmJean-Claude Sirard (Institut Pasteur de Lille / Inserm, France)
"Type 3 Innate Lymphoid Cells in Antibacterial Immunity"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNovel Effector Antimicrobial Mechanisms
Discussion Leader: Scott Evans (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:30 amVojo Deretic (University of New Mexico Health Sciences Center, USA)
"Autophagy for Elimination of Intracellular Pathogens"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amPaul Kubes (University of Calgary, Canada)
"Intravascular Immunity in Lung Host Defense"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amChristopher Evans (University of Colorado, USA)
"Muc Genes in Airway Host Defense"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amKong Chen (University of Pittsburgh, USA)
"Epithelial IL-17R Is Required for Pulmonary Host Defense Against Klebsiella pneumoniae"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmDonald Davidson (University of Edinburgh, United Kingdom)
"Cathelicidins Have Direct Antiviral Activity Against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmKrishnendu Chakraborty (University of Pittsburgh School of Medicine, USA)
"PPAR Gamma SUMOylation by Oxidized Phosholipid Blocks IL-10 Production Promoting Non-Resolving Pneumonia"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmControl of Injury and Repair in Acute Respiratory Infection
Discussion Leader: Samithamby Jeyaseelan (Louisiana State University, USA)
7:30 pm - 8:00 pmJahar Bhattacharya (Columbia University, USA)
"Lung Macrophage-Epithelial Cell Interactions Regulate Alveolar Inflammation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmHal Chapman (University of California, San Francisco, USA)
"Lineage-Negative Progenitor Cells in Lung Repair Post Influenza Pneumonia"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAmanda Jamieson (Brown University, USA)
"Stress Management: Host Resilience to Respiratory Infections"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms of Microbial Pathogenesis
Discussion Leader: Alice Prince (Columbia University, USA)
9:00 am - 9:30 amJaime Hook (Columbia University Medical Center, USA)
"Optical Studies of Alveolar Injury Due to Staphylococcus Infection"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amPradeep Singh (University of Washington School of Medicine, USA)
"Evolution in Isolated Lung Regions Drives Bacterial Diversification in Human Infections"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amAndreas Wack (Francis Crick Institute, United Kingdom)
"Pathogenic Role of Type I Interferons in Acute Influenza Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amCarolina Lopez (University of Pennsylvania, USA)
"Defective Viral Genomes as Primary Danger Signals During Respiratory Syncytial Virus Infections in Mice and Humans"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmMichael Otto (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Key Role for Alpha-Toxin in Fatal Pneumonia Caused by Staphylococcus aureus Sequence Type 398"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmBret Sellman (MedImmune, LLC, USA)
"S. aureus Alpha Toxin Potentiates Gram-Negative Lung Infections by Altering Macrophage Killing Function"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Lung Microbiome in Health and Disease
Discussion Leader: David Corry (Baylor College of Medicine, USA)
7:30 pm - 8:00 pmBenjamin Marsland (University Hospital of Lausanne, Switzerland)
"Influence of the Gut Microbiome on Lung Immunity"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRobert Dickson (University of Michigan, USA)
"The Forgotten Organ: Critical Illness and the Microbiome"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMichael Surette (McMaster University, Canada)
"The Changing Microbiome with Age and Susceptibility to Respiratory Infections"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvolving Concepts in Immune Memory of the Lung
Discussion Leader: Bart Lambrecht (Ghent University - VIB, Belgium)
9:00 am - 9:30 amChristopher Chiu (Imperial College London, United Kingdom)
"Role of Airway-Surveilling Memory CD8+ T Cells in Mucosal Protection Against RSV"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amJoseph Mizgerd (Boston University School of Medicine, USA)
"Heterotypic Immunity in the Lung"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amAndre Ballesteros-Tato (University of Alabama at Birmingham, USA)
"Foxp3+ T Follicular Regulatory Cell Responses During Influenza Virus Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amKris Lambert Emo (University of Rochester, USA)
"CD8+ T Cell Migration During Influenza Infection"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmJuliet Morrison (University of Washington, USA)
"Identification of Immune Cell Types that Associate with Severe Influenza Disease or Recovery in Mice Using Digital Cell Quantification"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJua Iwasaki (Imperial College London, United Kingdom)
"Transcriptomic and Proteomic Analysis Reveal Novel Immune Signatures in the Host Response to Influenza Infection in a Mouse Model"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEmerging Microbial Pathogens: Animal Modeling to Human Disease
Discussion Leader: Dawn Bowdish (McMaster University, Canada)
7:30 pm - 8:00 pmStacey Schultz-Cherry (St. Jude Children's Research Hospital, USA)
"Imaging of Influenza Virus Transmission and Protection"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMatthew Frieman (University of Maryland, USA)
"Pathogenesis and Therapeutic Development for Emerging Coronaviruses"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmFrank Deleo (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Neutrophil Interactions with Carbapenem-Resistant Klebsiella pneumoniae"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Host Response in Lung Infection: Genes and Environment
Discussion Leader: Joseph Mizgerd (Boston University School of Medicine, USA)
9:00 am - 9:30 amMichael Ciancanelli (Rockefeller University, USA)
"Novel Mutations Underlying Susceptibility to Severe Influenza Disease in Humans"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amBenjamin Suratt (University of Vermont, USA)
"Obesity Related Alterations in Lung Host Defense"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amDavid Corry (Baylor College of Medicine, USA)
"Airway Mycosis and the Influence on Lung Immune Responses"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amRachel Temple (Geisel School of Medicine, Dartmouth College, USA)
"When Signals Get Crossed: The Consequences of Dual Allergen- and Influenza-Mediated Signaling in Mast Cells"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmScott Evans (University of Texas MD Anderson Cancer Center, USA)
"Synergistic Toll-Like Receptor Signaling in Lung Epithelial Cells Induces Mitochondrial Reactive Oxygen Species-Dependent Antiviral Resistance"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmRobert Couch (University of Texas Medical Branch, USA)
"Both SARS and MERS Coronavirus Vaccinations Can Lead to Immunopathology when Challenged with Infectious Virus"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPrevention of Lung Infection: Novel Vaccination Approaches
Discussion Leader: Jay Kolls (University of Pittsburgh School of Medicine, USA)
7:30 pm - 8:00 pmMihai Netea (Radboud University Nijmegen Medical Centre, The Netherlands)
"Trained Innate Immunity"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDawn Bowdish (McMaster University, Canada)
"Immunosenescence and Novel Vaccination Strategies in the Elderly"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlfredo Torres (University of Texas Medical Branch, USA)
"Mucosal Vaccination Using Attenuated Bacterial Strains of Burkholderia"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1R13AI124513 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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