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Protein Transport Across Cell Membranes
Gordon Research Conference

Protein Transport Across Cell Membranes: Mechanism, Structure, and Regulation

Dates

March 6-11, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Steven M. Theg & Shu-Ou Shan

Vice Chairs:
William R. Skach & Trevor Lithgow

Meeting Description

This meeting brings together an international group of researchers who share interests in the mechanisms of protein transport across and into cellular membranes. This topic has attracted great interest given that approximately 50% of all proteins made in eukaryotic cells and 30% of those synthesized in bacteria are transported across or into one or more membranes to reach their final functional locations. In addition, numerous human pathologies are related to protein mistargeteing or the secretion of virulence factors. Sessions are organized around different topical foci, including targeting of proteins to membranes, protein translocation across and into membranes, dislocation and quality control mechanisms, regulation of translocation, protein secretion in pathogens, and new paradigms in protein translocation. Talks by invited speakers will be supplemented by shorter talks chosen from abstract submissions. This conference will provides opportunities for the interaction of both established leaders in the field and early career scientists who will become the leaders in the future.

Related Meeting

This GRC was held in conjunction with the "Protein Transport Across Cell Membranes" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmGeneral Principles of Protein Targeting to Different Cellular Locations
Discussion Leader: Tassos Economou (Rega Institute for Medical Research, KU Leuven, Belgium)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmManu Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
"Transmembrane Domain Recognition During Protein Targeting, Translocation, and Degradation"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmPaul Jarvis (University of Oxford, United Kingdom)
"Protein Transport in Plastids"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmNikolaus Pfanner (Universitaet Freiburg, Germany)
"Transport and Assembly of Mitochondrial Proteins"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTargeting to Membranes
Discussion Leader: Matthias Muller (Universitaet Freiburg, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amIrmgard Sinning (University of Heidelberg, Germany)
"Mechanism of Protein Targeting to the Endoplasmic Reticulum"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRobert Keenan (University of Chicago, USA)
"Targeting of Tail-Anchored Membrane Proteins to the Endoplasmic Reticulum"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:50 amStephen White (University of California, Irvine, USA)
"The Fate of Signal Sequences and Transmembrane Segments Inserted by SecA"
10:50 am - 10:55 amDiscussion
10:55 am - 11:10 amHans-Georg Koch (University of Freiburg, Germany)
"O-Translational Protein Targeting: SRP Interaction with the Ribosomal Tunnel Interior Facilitates Early Substrate Recognition"
11:10 am - 11:15 amDiscussion
11:15 am - 11:40 amGunnar Von Heijne (Stockholm University, Sweden)
"Cotranslational Protein Folding"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmFu-Cheng Liang (California Institute of Technology, USA)
"Conformational Dynamics of a Membrane Protein Chaperone Enables Spatially-Regulated Substrate Capture and Release"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmRichard Zimmermann (Saarland University, Germany)
"Protein Transport into the Human ER"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProtein Translocation Across Membranes
Discussion Leader: Richard Zimmermann (Saarland University, Germany)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmLong Li (Harvard Medical School, USA)
"Crystal Structure of a Substrate-Engaged SecY Protein-Translocation Channel"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmEkaterina Eimer (Institute for Biochemistry and Molecular Biology, University of Freiburg, Germany)
"Intramembrane, Charged Residues Important for the Functional Assembly of the Tat Translocase"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmToshiya Endo (Kyoto Sangyo University, Japan)
"Protein Import into Mitochondria"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmBen Berks (University of Oxford, United Kingdom)
"Assembling the Tat Translocase"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInsertion into Membranes
Discussion Leader: Ross Dalbey (Ohio State University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amAndreas Kuhn (University of Hohenheim, Germany)
"Bacterial Membrane Protein Insertion"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amThomas Miller (California Institute of Technology, USA)
"Long Timescale Molecular Dynamics Simulation of Protein Translocation at the Sec61p Complex"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMarcelo Sousa (University of Colorado Boulder, USA)
"Structure and Mechanism of the Beta-Barrel Assembly Machine"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amRoland Beckmann (Gene Center, University Munich, Germany)
"Structure and Dynamics of the YidC:Ribosome Complex upon Membrane Protein Biogenesis"
11:30 am - 11:35 amDiscussion
11:35 am - 12:00 pmArnold Driessen (University of Groningen, The Netherlands)
"Cellular Localization and Lipid Activation of the SecA Motor Protein"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShinobu Chiba (Kyoto Sangyo University, Japan)
"Use of Bacillus subtilis MifM to Dissect the YidC Functions to Facilitate Membrane Protein Insertion"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDislocation and Quality Control
Discussion Leader: Randolph Hampton (University of California, San Diego, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmYihong Ye (National Institutes of Health, USA)
"Unconventional Protein Secretion in Protein Quality Control"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmBrendan Battersby (University of Helsinki, Finland)
"Quality Control of Mitochondrial Protein Synthesis Is Required for Membrane Integrity"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmMalaiyalam Mariappan (Yale University, USA)
"A New Role for the Sec61 Translocon in the UPR"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmTerrence Oas (Duke University, USA)
"The Effect of Thermodynamic Stability on the Secretion of a Rapidly Unfolding/Folding Protein"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Import into Organelles
Discussion Leader: Carla Koehler (University of California, Los Angeles, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amRalf Erdmann (Ruhr-University Bochum, Germany)
"Protein Import into Peroxisomes"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amPeter Rehling (University of Gottingen, Germany)
"Protein Transport of Presequence-Containing Precursors into Mitochondria"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 amCoffee Break
10:35 am - 10:50 amChristopher Carrie (Ludwig-Maximilians-Universität München, Germany)
"A Plant Mitochondrial Tat Pathway"
10:50 am - 10:55 amDiscussion
10:55 am - 11:10 amMichael Conti (University of California, Los Angeles, USA)
"Small Molecule Inhibitors Display Distinct Phenotypes in a Parkinson’s Disease Mechanism"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amDanny Schnell (Michigan State University, USA)
"Multi-Functional Roles for the POlypeptide TRansport Associated (POTRA) Domains of Toc75 in Chloroplast Protein Import"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmCarole Dabney-Smith (Miami University (Ohio), USA)
"Characterization of a Chloroplast Twin Arginine Mutant in Arabidopsis thaliana Deficient in the Membrane Protein Hcf106"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmChris Williams (University of Groningen, The Netherlands)
"Mapping the PMP Export Pathway of Peroxisomes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRegulation of Translocation
Discussion Leader: Bil Clemons (California Institute of Technology, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmMing Liu (University of Michigan, USA)
"Targeting Proinsulin Dimerization Interface to Prevent Beta Cell Failure and Diabetes Caused by Misfolded Proinsulin"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmKatharina Wiesemann (Goethe University Frankfurt, Germany)
"The TOC GTPases Are Regulated by a Multistep Dimerization Cycle"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmHsou-Min Li (Academia Sinica, Taiwan)
"CRK Support for a Sweet Hypothesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRandolph Hampton (University of California, San Diego, USA)
"Giving the Cold Shoulder to Retrotranslocation: Genetic Strategies to Discover ERAD Dis-Location Factors"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPathogenic Secretion
Discussion Leader: Harris Bernstein (National Institutes of Health, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amGabriel Waksman (Birkbeck, University of London, United Kingdom)
"Structural and Molecular Biology of Bacterial Type IV Secretion Systems"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amPatricia Clark (University of Notre Dame, USA)
"Connections Between Autotransporter Protein Folding Properties and Secretion Efficiency"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:00 amKonstantin Korotkov (University of Kentucky, USA)
"Structural Basis of PE-PPE Protein Translocation by Mycobacterial ESX Secretion Systems"
11:00 am - 11:05 amDiscussion
11:05 am - 11:25 amShruthi Hamsanathan (Texas A&M University, USA)
"The Hairpin-Hinge Model of Tat Protein Transport"
11:25 am - 11:35 amDiscussion
11:35 am - 11:50 amVivianne Goosens (Imperial College London, United Kingdom)
"Unravelling Type 4 Pili Assembly"
11:50 am - 11:55 amDiscussion
11:55 am - 12:20 pmDaniel Wall (University of Wyoming, USA)
"Bacterial Kin Recognition and Protein Transport Between Outer Membranes"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Paradigms in Translocation
Discussion Leader: Hsou-Min Li (Academia Sinica, Taiwan)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmFeng Shao (National Institute of Biological Sciences, China)
"An Iron-Containing Dodecameric Heptosyltransferase Family Modifies Bacterial Autotransporters in Pathogenesis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmYing Zhang (University of Freiburg, Germany)
"Cotranslational Intersection Between the SRP- and GET-Targeting Pathways to the ER of Saccharomyces cerevisiae"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:50 pmTracy Palmer (University of Dundee, United Kingdom)
"The Type VII Secretion System of Staphylococcus aureus"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSiegfried Musser (Texas A&M Health Science Center, USA)
"Macromolecular Crowding in Nuclear Pores"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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