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Physical Virology
Gordon Research Conference

Structure-Function Relations in Viruses and Virus-Like Materials

Dates

January 29 - February 3, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Brian Bothner & Jeroen J.L.M. Cornelissen

Vice Chairs:
Wouter H. Roos & Tuli Mukhopadhyay

Meeting Description

The inception of the GRC on Physical Virology in 2009 was born of the desire to bring together scientists with an interest in applying a multidisciplinary approach that includes biology, biophysics, chemistry, mathematics, material science, physics, and virology, to understanding the basic biology of viruses. While this diversity in disciplines is a plus, it posed challenges because of the poor communication between the disciplines. The goal of this conference was thus to bring together, for a first time, the physical, biological, and materials perspectives that was driving the research in the field of viruses as multifunctional systems with increasing utility in material science and biomedicine. Significantly, a Gordon Research Seminar (GRS), organized by graduate students and held in conjunction with the parent GRC meeting on the same topic, provided the opportunity for young scientists to present their work to their peers and senior scientists in the field. Interest and attendance of joint meetings has continued to grow, and in this the 5th biennial GRC Physical Virology meeting, the first to be held at a European site, the emphasis will continue to have the following objectives: 1. To provide a forum for virologists, bioengineers, chemists, materials scientists, physicists, biologists, and clinicians to present current research on the fundamental understanding of the relationship between virus structure and function. 2. To initiate interdisciplinary collaborative interactions between scientists interested in biological, biomedical, colloidal, and self-assembled materials to facilitate the design of advanced materials, with a particular focus on applications in health care. 3. To establish opportunities for fostering biomedical and industrial applications of virus-derived materials. 4. To provide an opportunity for young scientists (graduate students and postdoctoral fellows) to present their research results and interact with established members of the field.

Related Meeting

This GRC was held in conjunction with the "Physical Virology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Virus Assembly: Theory and Practice
Discussion Leader: Brian Bothner (Montana State University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmAdam Zlotnick (Indiana University, USA)
"Virion-Based Therapeutics: Small Molecules Affect Virus Structure and Dynamics"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmTrevor Douglas (Indiana University, USA)
"Nano-Reactor Assembly Across Multiple Length Scales"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMaterials and Devices
Discussion Leader: Mauri Kostiainen (Aalto University, Finland)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amNicole Steinmetz (Case Western Reserve University, USA)
"Plant Virus-Based Therapeutics and Contrast Agents"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMatthew Francis (University of California, Berkeley, USA)
"Viral Capsids for Drug Delivery and 3-D Nanomaterial Construction"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amClaudia Koch (University of Stuttgart, Germany)
"Tobacco Mosaic Virusbased Biosensors"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amXian-En Zhang (Institute of Biophysics, Chinese Academy of Sciences, China)
"Viral and Microbial Elements as Building Blocks for Nanobiosensor Platform"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMarta Bally (Chalmers University of Technology, Sweden)
"Cell-Surface Mimics to Probe Interactions Between Herpes Simplex Viruses and Cell-Surface Carbohydrates"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Hyukjun Choi (Ulsan National Institute of Science and Technology (UNIST), South Korea)
"Development of Functional Nano-Building Blocks and Nano-Reaction Clusters"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Mavis Agbandje-McKenna (University of Florida, USA) and Tuli Mukhopadhyay (Indiana University Bloomington, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBiomedical Applications
Discussion Leader: M.G. Finn (Georgia Institute of Technology, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmMaya Schmulevitz (University of Alberta, Canada)
"Reshaping Oncolytic Reovirus for the Tumor Niche"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmKah Peng (Mayo Clinic College of Medicine, USA)
"Viruses as Oncolytic Agents: Preclinical and Clinical Insights"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmMavis Agbandje-McKenna (University of Florida, USA)
"Engineering AAV Vectors for Clinical Application"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmStructural Studies of Viruses
Discussion Leader: Mavis Agbandje-McKenna (University of Florida, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amPepe Caston (Spanish National Research Council (CSIC), Spain)
"Structural Virotechnology or How 3D Cryo-EM Facilitates Viral Biotechnology"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amKay Grunewald (University of Oxford, United Kingdom)
"Structural Analysis of Herpes Virus Infection"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Sven Eyckerman (VIB, Ghent University, Belgium)
"Virotrap: Abducting Protein Complexes from Mammalian Cells"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amHong Zhou (California NanoSystems Institute, UCLA, USA)
"Viral RNA Genomes by CryoEM: Atomic Structures and Mechanisms of Action"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmCharlotte Uetrecht (Heinrich Pette Institute / European XFEL, Germany)
"Flying Viruses - From Biophysical to Structural Characterization"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Mark de Ruiter (University of Twente, The Netherlands)
"Assembling Enzymatic Cascade Inside Virus-Based Nanocompartments Using Dual-Tasking Nucleic Acid Tags"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmVirus Structure-Function
Discussion Leader: Robert McKenna (University of Florida, USA)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmKristin Parent (Michigan State University, USA)
"Decoration Mechanism of PhageL Capsids"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:05 pmJonathan Pokorski (Case Western Reserve University, USA)
"Polymer Based Protein Engineering Using Viral Nanoparticles"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Antonette Bennett (University of Florida, USA)
"Stability and Structure of True-Type AAV2 Correlated to Improved Neuronal Transduction"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmCarlos Catalano (University of Colorado Anschutz Medical Campus, USA)
"Capsid Assembly and Stabilization by Decoration Proteins"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAssembly and Biomechanics of Viruses
Session in memory of Dr. William Klug.
Discussion Leader: Charles Knobler (University of California, Los Angeles, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amWilliam Gelbart (University of California, Los Angeles, USA)
"Some New Twists on CCMV Self-Assembly, 50 Years After Bancroft"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amAlex Evilevitch (University of Illinois at Urbana-Champaign, USA)
"Genome Encapsidation and Release"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amRoya Zandi (University of California, Riverside, USA)
"In Vitro Protease Cleavage and Computer Simulations Reveal the HIV-1 Capsid Maturation Pathway"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmMartin Lawrence (Montana State University, USA)
"Acidianus Tailed Spindle Virus: A New Structural Paradigm for Viral Assembly"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Raphael Frey (ETH Zurich, Switzerland)
"Capsid Forming Lumazine Synthase as a Container for Enzymatic Reactions"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmViruses with Membranes
Discussion Leader: Felix Rey (Institut Pasteur, France)
6:00 pm - 6:25 pmSusan Daniel (Cornell University, USA)
"An Engineering Approach to Probing Host-Pathogen Interactions Using Single Virion Tracking Microscopy"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmKelly Lee (University of Washington, USA)
"Interplay of Protein and Membrane Intermediates During Influenza Virus Fusion"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:35 pmMark Sansom (University of Oxford, United Kingdom)
"Molecular Simulations to Characterise Viral Membranes and Their Interactions"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Jelle Blijleven (University of Groningen, The Netherlands)
"Single-Particle Studies of Chikungunya Membrane Fusion"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmProtein Cages by Design
Discussion Leader: Adam Zlotnick (Indiana University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDonald Hilvert (ETH Zurich, Switzerland)
"Design, Structure and Applications of Scalable Protein Cages"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amRoman Jerala (National Institute of Chemistry, Slovenia)
"Design of Protein Origami Cages"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Kariem Ezzat Ahmed (Karolinska Institute, Sweden)
"Pronanotechnology (Nanoparticle Prodrugs): In-Vivo Self-Assembly for Enhanced Biodistribution"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amJunghae Suh (Rice University, USA)
"Designing Viruses as Biocomputing Nanodevices"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMichael Hagan (Brandeis University, USA)
"How Icosahedral Shells Assemble on and Bud from Fluid Cargoes and Lipid Membranes"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Anna Czapar (Case Western Reserve University, USA)
"Tobacco Mosaic Virus as a Nanocarrier for Drug Delivery"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmKeynote Session: Enabled Studies of Viruses
Discussion Leader: Jeroen Cornelissen (University of Twente, The Netherlands)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:45 pmTodd Yeates (University of California, Los Angeles, USA)
"Design Strategies and Structural Validation of Protein Cages and Other Symmetric Nanomaterials"
6:45 pm - 7:00 pmDiscussion
7:00 pm - 7:35 pmFelix Rey (Institut Pasteur, France)
"Virion Dynamics and Immunogenicity Profile: Combining These Data to Develop an Efficient Vaccine Against Dengue and Zika Viruses"
7:35 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Allergy And Infectious Diseases of the National Institutes of Health under Award Number R13AI129379. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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