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Tropical Infectious Diseases
Gordon Research Conference

Advances in Basic and Translational Research in Tropical Infectious Diseases

Dates

March 12-17, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Jesus Valenzuela

Vice Chair:
Carolina Barillas-Mury

Meeting Description

The 2017 Gordon Research Conference on Tropical Infectious Diseases will present cutting edge research on the most prevalent and medically important tropical infectious diseases (TIDs). This will be the fifth time that this particular GRC will be held, and it will have a thematic organization similar to that of the very successful conference held in 2015. The intent is to gather a multidisciplinary community of scientists and discuss cutting edge basic, field-based and translational research in TIDs.

The 2017 GRC will include disease-focused sessions on arboviral diseases (including dengue, chikungunya and Zika), helminth infections, malaria and Chagas disease. In addition there will be thematic sessions, including Microbiomes of Tropical Diseases Vectors, Advances in Vector Biology, and Advances in Translational Strategies to Prevent Tropical Diseases. For each session, invited speakers who are at the forefront of their respective fields will discuss how progress made at the bench is being translated to actions in the field, emphasizing interventions based on treatment, vaccination, or interrupting the transmission cycle in the vector or reservoir hosts.

An important goal of the GRC is to attract junior scientists and graduate students, including those from disease endemic countries, to present their work in poster format and exchange ideas with leaders in the field. Following a successful format from the previous conference, there will be a 2-day Gordon Research Seminar (GRS) organized for senior doctoral students and postdoctoral researchers. Selected participants will give oral presentations and present posters in a setting that promotes networking and gears them towards the GRC that follows on the next day. There will also be a discussion panel organized during the GRS, on careers in science, and participants will have the opportunity to interact with the panel members during the GRS and GRC. The GRS will be an excellent opportunity for highly motivated junior investigators from disease endemic areas to develop collaborations with senior investigators and strengthen on-going research in their own countries.

The Conference will be held in a historic seaside hotel in Galveston, Texas, which offers relaxing beaches and one of the best-preserved concentrations of Victorian architecture in the country. The presentations of cutting edge research, along with the programmed discussion sessions and opportunities for informal gatherings in the afternoons and evenings, will serve to greatly enrich the community of multidisciplinary scientists working on TIDs.

Related Meeting

This GRC was held in conjunction with the "Tropical Infectious Diseases" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Arboviruses and Vector-Parasite Interactions
Discussion Leader: Jesus Valenzuela (National Institutes of Health, USA)
7:40 pm - 8:20 pmScott Weaver (University of Texas Medical Branch, USA)
"Emerging Urban Arboviruses Invading the Americas: Chikungunya, Zika and What Next?"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmSerap Aksoy (Yale University School of Medicine, USA)
"Eliminating Sleeping Sickness: Expanding the Vector Control Toolbox"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmResearch and Control for Worms and Neglected Bacteria
Discussion Leaders: Maria Elena Bottazzi (Baylor College of Medicine, USA) and Nelly El-Sakkary (University of California, San Diego, USA)
9:00 am - 9:15 amLynn Soong (The University of Texas Medical Branch, USA)
"Type 1-Skewed Neuroinflammation and Vascular Leakage Associated with Orientia tsutsugamushi Infection"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMonica Vieira (Instituto Butantan, Brazil)
"Heparin-Binding Protein Release Is Strongly Induced by Leptospira spp. and Is a Candidate as Early Diagnostic Marker of Human Leptospirosis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amBo Wang (Stanford University, USA)
"Exploiting Schistosome-Host Cell Interactions Using Nano Scale Tools"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amAlex Loukas (James Cook University, Australia)
"Hookworms Ain't All Bad News: Treating Inflammatory Diseases with Hookworms and Their Secreted Proteins"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMeera G. Nair (University of California, Riverside, USA)
"Function of Monocytes and Macrophages in Immunity and Inflammation to Hookworms"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amConor Caffrey (University of California, San Diego, USA)
"Small-Molecule Drug Screening Approaches for Helminth Parasites"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPeter Hotez (Baylor College of Medicine, USA)
"Pursuing Anthelminthic Vaccines to Achieve Sustainable Development Goals"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Carolina Barillas-Mury (National Institutes of Health, USA) and Serap Aksoy (Yale University School of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChagas Disease and Leishmaniasis, Pathogenesis and Immunity
Discussion Leaders: Eric Dumonteil (Tulane University, USA) and Laura-Isobel McCall (University of California, San Diego, USA)
7:30 pm - 7:45 pmSantuza Teixeira (Federal University of Minas Gerais, Brazil)
"Surface Proteins as Virulence Factors in Trypanosoma cruzi and Leishmania: The Case for Trans-Sialidases and Amastins"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmNisha Garg (University of Texas Medical Branch, USA)
"Multiple Roles of Mitochondria in Chagas Disease"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:35 pmIgor Almeida (University of Texas at El Paso, USA)
"Glycan-Based Vaccine for Chagas Disease"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmWalderez Dutra (Federal University of Minas Gerais, Brazil)
"Cellular and Molecular Mechanisms of Protective and Pathogenic Immune Response in Chagas Disease"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmNathan Peters (University of Calgary, Canada)
"Recruitment, Modulation, and Activation of Inflammatory Cells in the Skin Following Infection with Leishmania: Implications for Vaccination"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEmergent Arboviruses: Zika, Dengue and Chikungunya
Discussion Leaders: Nikos Vasilakis (University of Texas Medical Branch, USA) and Berlin Londono-Renteria (Kansas State University, USA)
9:00 am - 9:20 amAlbert Ko (Yale School of Public Health, USA)
"Zika Virus Congenital Syndrome and Its Emergence in the Americas"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGeorge Dimopoulos (Johns Hopkins Bloomberg School of Public Health, USA)
"Zika Virus – Mosquito Interactions: Exploring Transmission Bottlenecks"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSasha Azar (University of Texas Medical Branch, USA)
"Vector Competence Analysis of Aedes spp. Mosquitoes from the Americas for Zika Virus"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSujatha Sunil (International Centre for Genetic Engineering and Biotechnology, India)
"Role of Aedes microRNAs in Chikungunya Virus Replication"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amEva Harris (University of California, Berkeley, USA)
"New Findings in Zika Pathogenesis, Immunology, and Diagnostics"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amShee-Mei Lok (Duke-NUS Medical School, Singapore)
"Structure of the Thermally Stable Zika Virus"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmStephen Whitehead (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Development of a Sustainable Live Attenuated Vaccine Candidate for Zika Virus"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMicrobiomes of Vectors and Leishmania
Discussion Leaders: Serap Aksoy (Yale University School of Medicine, USA) and Fabio Gomes (National Institute of Allergy and Infectious Disease, NIH, USA)
7:30 pm - 7:50 pmMartin Olivier (McGill University, Canada)
"Impact of Sand Fly Nanobiome on Cutaneous Leishmaniasis Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmStephen Beverley (Washington University in St. Louis, USA)
"Leishmania RNA Viruses and Parasite Virulence"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMary Wilson (University of Iowa, USA)
"The Contribution of Insect Microbiota to Vector-Borne Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShaden Kamhawi (National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Unlikely Suspect: A Vital Role for Midgut Microbiota in Virulence of Vector-Transmitted Leishmania Parasites"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Vector Biology Research
Discussion Leaders: Saravanan Thangamani (University of Texas Medical Branch, USA) and Iliano Coutinho-Abreu (National Institutes of Health, USA)
9:00 am - 9:20 amJoao Pedra (University of Maryland School of Medicine, USA)
"Tick Inhibition of NLRC4 Inflammasome Activation During Microbial Transmission"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAlvaro Molina-Cruz (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Plasmodium Evasion of Mosquito Immunity and the Global Spread of Malaria"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPamela Pennington (Universidad del Valle de Guatemala, Guatemala)
"Paratransgenesis: The Unlikely Road from Lab to Field"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amBrian Weiss (Yale School of Public Health, USA)
"Colonization of the Tsetse Fly Midgut with Commensal Enterobacter Inhibits Trypanosome Infection Establishment"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amTiago Serafim (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Beyond Metacyclogenesis: The Secret Behind the Remarkable Success of Leishmania Transmission by a Vector Bite"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amAbdoulaye Diabate (Institute de Recherche en Sciences de la Sante (IRSS) / Centre Muraz, Burkina Faso)
"GM Fungi to Control Insecticide Resistant Mosquito Populations"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmAnandasankar Ray (University of California, Riverside, USA)
"Mosquito Behavior Modifying Odors as Prophylactics for Malaria, Dengue and Zika"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBasic and Field Work Advances in Malaria
Discussion Leaders: Rick Fairhurst (National Institutes of Health, USA) and Joel Vega-Rodriguez (Johns Hopkins University, USA)
7:30 pm - 7:45 pmXin-Zhuan Su (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Immunogenomics of Malaria: Genome-Wide Host-Parasite Interactions and Novel Regulators in IFN-I Signaling"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmRongfu Wang (Houston Methodist Research Institute, USA)
"Cross-Regulation of Type I IFN Signaling Pathways in pDCs Dictates Anti-Malaria Immunity and Host Mortality"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmKirk Deitsch (Weill Cornell Medicine, USA)
"Mechanisms for Coordinating Expression of Multicopy Gene Family Members in Malaria Parasites"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmPeter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Unraveling the Cellular and Molecular Basis of Immunity to Malaria"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmPeter Billingsley (Sanaria Inc., USA)
"PfSPZ Vaccines to Prevent and Eliminate Malaria"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTranslational Strategies to Prevent Tropical Diseases
Discussion Leaders: Peter Hotez (Baylor College of Medicine, USA) and Fabiano Oliveira (National Institutes of Health, USA)
9:00 am - 9:20 amAfzal Siddiqui (Texas Tech University Health Sciences Center School of Medicine, USA)
"Sm-p80-Based Vaccine for Intestinal and Urinary Schistosomiasis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSteven Reed (Infectious Disease Research Institute, USA)
"Designer Adjuvants for Neglected Infectious Diseases"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amHira Nakhasi (Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration, USA)
"Early Interaction Between DCs and the Live Attenuated Leishmania donovani Parasites Reveals Novel Biomarkers of Protective Immunity Against Visceral Leishmaniasis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amCamila De Oliveira (Fundação Oswaldo Cruz, Brazil)
"Estimating Vector Exposure and Risk of CL Development Using Lutzomyia intermedia Linb13"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amAlvaro Acosta-Serrano (Liverpool School of Tropical Medicine, United Kingdom)
"Targeting Tyrosine Metabolism as a Novel Approach for Tsetse Control"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amMaria Elena Bottazzi (Baylor College of Medicine, USA)
"Global Access Strategies for NTD Vaccines: Translating Science into Sustainable Business Cases and Innovative Investment Mechanisms"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLuciano Moreira (Centro de Pesquisa Rene Rachou, Fiocruz Minas, Brazil)
"Using Wolbachia in an Integrative Approach to Control Arboviruses"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Host-Parasite Interactions and Innate Immunity
Discussion Leader: Carolina Barillas-Mury (National Institutes of Health, USA)
7:30 pm - 8:15 pmRicardo Gazzinelli (Centro de Pesquisa Rene Rachou, Fiocruz Minas, Brazil)
"Killing of Plasmodium vivax Infected Reticulocytes by Killer T Cells"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmMarcelo Jacobs-Lorena (Johns Hopkins Bloomberg School of Public Health, USA)
"What Peptides Taught Us About the Life Cycle of the Malaria Parasite"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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