Gordon Research Conferences
Meeting Details
Search:
  GO

Angiotensin
Gordon Research Conference

Angiotensin: From Cell Biology and Signaling Networks to Novel Physiological Paradigms and Therapeutics

Dates

February 21-26, 2016

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Curt D. Sigmund

Vice Chair:
Toshiro Fujita

Meeting Description

One of the highlights of the meeting will be a session dedicated to the new class of compound that has resulted from research on the renin-angiotensin system (RAS) and vasoactive peptides, the angiotensin receptor and neprilysin inhibitor. Other highlights will come from sessions on signaling networks that interface with the RAS, miRNAs, and their importance in cardiovascular physiopathology and therapeutics. There will be presentations on state-of-the-art novel technologies, such as genome editing and optogenetics, and their applications to study the RAS. Other sessions will address the regulation of angiotensin synthesis and action in the kidney and in the brain, on the immune system and on salt and metabolism, thereby proposing new pathophysiological paradigms. Lastly, we will have a follow-up session on the unsolved intracrine functions of angiotensin.

In addition to cutting-edge science, this meeting will also perpetuate the tradition of forging new friendships and establishing new cross-disciplinary national and international collaborations for the RAS community. Established investigators and trainees at all levels gather together in a very picturesque setting in a collegial and informal atmosphere where discussions begin over breakfast and continue during the afternoon and late at night through convivial gatherings after the evening sessions. Early career scientists and students will have the occasion to discuss their unpublished data with distinguished leaders throughout the conference, and will have the opportunity to present their work in dedicated slots throughout the program.

Related Meeting

This GRC was held in conjunction with the "Angiotensin" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Regulation and Genetics of the Renin-Angiotensin-Aldosterone System
Discussion Leader: Curt Sigmund (University of Iowa, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmArmin Kurtz (University of Regensburg, Germany)
"Regulation of Renin Expression and Secretion in the Kidney, Modes and Mechanism"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmXavier Jeunemaitre (Paris Descartes University, France)
"Molecular Genetics and Pathways Involved in Patients with Low Renin and Pseudo-Aldosteronism"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRenin Angiotensin Aldosterone Blockers: Are Dual Specificity Inhibitors the Next Great Thing?
Discussion Leaders: Rhian Touyz (University of Glasgow, United Kingdom) and Jan Danser (Erasmus MC, The Netherlands)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amJohn McMurray (University of Glasgow, United Kingdom)
"Angiotensin Receptor Neprilysin Inhibition – The New Paradigm"
9:40 am - 9:50 amDiscussion
9:50 am - 10:10 amLodi Roksnoer (Erasmus MC, The Netherlands)
"Reno and Cardioprotective Effects of Dual AT1 Receptor-Neprilysin Inhibitors"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:00 amOliver Domenig (Medical University of Vienna, Austria)
"Comprehensive Biochemical Evaluation of the Renin-Angiotensin-System"
11:00 am - 11:05 amDiscussion
11:05 am - 11:20 amFumitoshi Satoh (Tohoku University Graduate School of Medicine, Japan)
"Novel Very Rapid Measurements of Active Renin and Aldosterone Concentrations and Its Clinical Significance for the Selection of Antihypertensive Agents"
11:20 am - 11:25 amDiscussion
Young Investigator Presentations
11:25 am - 11:30 amIntroduction by Discussion Leader
11:30 am - 11:40 amDouglas Bennion (University of Florida, USA)
"Human Serum ACE2 Activity in Ischemic Stroke: A Moving Target for Translational Treatments"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amKatrina Binger (Baker IDI Heart and Diabetes Institute, Australia)
"Conditional Deletion of the (Pro)Renin Receptor Leads to Disturbed Pancreatic Beta-Cell Homeostasis and the Onset of Severe Diabetes"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKristin Claflin (University of Iowa, USA)
"Control of Resting Metabolic Rate by Angiotensin AT1A Receptors in Leptin-Sensitive Cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJohannes Kovarik (Medical University of Vienna, Austria)
"Rise of Chymase Dependent Ang II Formation After Kidney Transplantation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Lisa Cassis (University of Kentucky, USA) and Rhian Touyz (University of Glasgow, United Kingdom)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRegulatory Networks and Clinical Relevance
Discussion Leader: Akira Nishiyama (Kagawa University Medical School, Japan)
6:00 pm - 6:25 pmRhian Touyz (University of Glasgow, United Kingdom)
"Chanzymes in Vascular Biology"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmYouhua Liu (University of Pittsburgh School of Medicine, USA)
"Wnt/β-Catenin Signaling and Renin Angiotensin System"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmMaira Soto (University of Southern California, USA)
"Modifying the Renin-Angiotensin System to Improve Pulmonary Health in Type 2 Diabetes"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmAdam Mullick (Ionis Pharmaceuticals, USA)
"LICA-Antisense Oligonucleotide Inhibition of Angiotensinogen: A New Therapeutic Approach for Treatment-Resistant Hypertension"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNew Roles for Renin, Renin Receptor and ACE in the Kidney
Discussion Leaders: Thomas Coffman (Duke-NUS Medical School, Singapore) and Rodrigo Fraga-Silva (Wyss Center for Bio and Neuroengineering, Switzerland)
9:00 am - 9:25 amMaria Louisa Sequiera-Lopez (University of Virginia, USA)
"Renin Cell Progenitors in Development and Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJorge Giani (Cedars-Sinai Medical Center, USA)
"Renal Tubular Epithelial ACE Is Obligatory for Experimental Hypertension"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amJohannes Stegbauer (Heinrich Heine University Düsseldorf, Germany)
"Ciliary Neurotrophic Factor Deficiency Protects Against Angiotensin II-Dependent Hypertension and Hypertensive End Organ Damage"
10:20 am - 10:25 amDiscussion
10:25 am - 10:50 amCoffee Break
10:50 am - 11:15 amMinolfa Prieto-Carrasquero (Tulane University, USA)
"Consequences of the Functional Role in the Prorenin Receptor in the Collecting Duct"
11:15 am - 11:25 amDiscussion
Selected Presentations from the GRS
11:25 am - 11:30 amIntroduction by Discussion Leader
11:30 am - 11:45 amDane Jensen (University of Nevada, Reno, USA)
"Epigenetic Regulation of Brain (Pro)Renin Receptor by Epithelial Sodium Channel in DOCA-Salt Hypertension"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmNicole Littlejohn (University of Iowa, USA)
"Suppression of Resting Metabolic Rate by the Angiotensin AT2 Receptor"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAntonio Peluso (University of Southern Denmark, Denmark)
"AT2-Receptor Stimulation Promotes NO Release Through eNOS Serine1177 Phosphorylation and eNOS Tyrosine657 Dephosphorylation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmImmunity, Inflammation and AT1 Receptors
Discussion Leader: Ulrich Wenzel (University Medical Center Hamburg-Eppendorf, Germany)
6:00 pm - 6:25 pmSteven Crowley (Duke University Medical Center, USA)
"A Role for Inflammatory Cytokines in the Pathogenesis of Hypertension"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmDaniela Carnevale (Neuromed Insitute for Neurosciences, Sapienza University of Rome, Italy)
"Neuroimmune Interactions in Hypertension"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmHamiyet Unal (Erciyes University, Turkey)
"Novel Function of RGS2 as a Transcriptional Repressor of STAT3 in Regulating Gene Expression Involved in AngII-Induced Pathogenesis"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmDuska Dragun (Charité - Universitätsmedizin Berlin, Germany)
"Structural and Functional Consequences of Antibody Mediated AT1R Activation"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Brain RAS
Discussion Leaders: Eric Lazartigues (LSU Health Sciences Center New Orleans, USA) and Dominik Muller (Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, Germany)
9:00 am - 9:25 amYumei Feng (University of Nevada, USA)
"Neuronal (Pro)Renin Receptor in High-Fat Diet Induced Diabetes and Obesity"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJavier Stern (Georgia Regents University, USA)
"Novel Insights into Central Mechanistic Targets Mediating AngII Actions in the Brain"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amKeisuke Shinohara (University of Iowa, USA)
"Selective Deletion of Intracellular Renin in the Brain Causes Hypertension and Elevated Sympathetic Nervous System Activity"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
Salt and Metabolism
10:55 am - 11:20 amJens Titze (Vanderbilt University, USA)
"Salt Metabolism: From Volume Control to Biological Barrier Formation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJonathan Jantsch (University of Regensburg, Germany)
"Salt Storage Creates Biological Barrier to Ward Off Infection"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmFrederique Yannikouris (University of Kentucky, USA)
"Adipocyte PRR, a New Target to Prevent Obesity-Hypertension?"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTechnical Advances in Optogenetics/Chemogenetics and Applications to Ang-II and Its Neural Circuits
Discussion Leader: Mingyu Liang (Medical College of Wisconsin, USA)
6:00 pm - 6:25 pmSergey Kasparov (University of Bristol, United Kingdom)
"An Overview of Current Optogenetic Actuators and Reporters"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmEric Krause (Univerisity of Florida, USA)
"Optogenetic Dissection of 'Angiotensin Sensitive' Brain Circuits: Implications for Mental and Cardiovascular Health"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmColin Sumners (University of Florida, USA)
"Hindbrain Angiotensin Type 2 Receptors and Hypertension"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmKamal Rahmouni (University of Iowa, USA)
"Opto- and Chemo-Genetic Mediated Modulation of POMC and AGRP Neurons"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmRecent Advances in the RAS
Discussion Leaders: Toshiro Fujita (The University of Tokyo, Japan) and Lisa Cassis (University of Kentucky, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMark Chappell (Wake Forest University, USA)
"An Intracellular Angiotensin-(1-7) System"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amKatie Hood (University of Glasgow, United Kingdom)
"The Ang-(1-7)-ET-1 Axis – A New Partnership"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amShigeru Shibata (University of Tokyo / Teikyo University, Japan)
"Uncovering Pathways Downstream of Angiotensin II Signaling in the Distal Nephron of the Kidney"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amSadashiva Karnik (Cleveland Clinic, USA)
"Molecular Recognition and Functional Selectivity Mechanisms of Angiotensin II Type 1 Receptor Blocking Drugs"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmKenneth Gross (Roswell Park Cancer Institute, USA)
"Renin-Expressing Cell Lineage and Progenitor Cell Function During Pancreatic Neuroendocrine Differentiation and Development"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenome and Editing and MicroRNAs
Discussion Leader: Michael Bader (Max Delbrück Center for Molecular Medicine, Germany)
6:00 pm - 6:25 pmMichael Bader (Max Delbrück Center for Molecular Medicine, Germany)
"Novel Transgenic Technologies for the Functional Analysis of the RAS"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 7:00 pmMingyu Liang (Medical College of Wisconsin, USA)
"MicroRNAs in Hypertension: From Cells to Human Subjects"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmYu Wang (University of Newcastle, Australia)
"Role of hsa-miR-181a in Regulating Human Placental Renin Expression and Prorenin Protein"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmAndrew Baker (University of Edinburgh, United Kingdom)
"miRNA Regulation and Function During Vascular Remodelling"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter