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Bioanalytical Sensors
Gordon Research Conference

From Atoms to Organisms: Bioanalytical Sensors Elucidating Physicochemical Properties of Multiscale Systems

Dates

June 26 - July 1, 2016

Location

Salve Regina University
Newport, RI

Organizers

Chairs:
Elizabeth Hall & Andre A. Adams

Vice Chairs:
Robin L. McCarley & Duncan Graham

Meeting Description

The field of Bioanalytical Sensors is inherently interdisciplinary. Basic and applied research in this area involve biology, biochemistry, medicine, physiology, chemistry, physics, and engineering to develop systems and instrumentation capable of transducing a molecular recognition event into a measurable signal. These systems may then be used to increase under-standing of biological phenomena, improve health and welfare, and enhance international security. The 2016 conference has been inspired by a modern healthcare system where diagnosis and management of chronic disease states introduces new challenges in detection, treatment and measurement and, where life style and fitness choices present new demands as people seek to take more responsibility for their own health, treatment and care. Healthcare is moving from reactive treatment to preventative medicine and this drive in the culture is pushing the momentum for a new generation of bioanalytical sensing systems, that provide value in their data, are economically compelling and technically realistic. The focus is forward looking and the program will feature wearables and portables in the discussion and pull it all together with new analytical platforms to challenge future directions. We will explore the most recent molecular and whole sample imaging and spectrometry, while debating how synthetic biology and nano-fabrication can impact structure and functional design solutions. Rapid advances in development of smaller, more rapid, automated, and more sensitive bioanalytical sensors will spur economic development of marketable products for environmental, health- and security-related fields, and basic scientific endeavors.

Related Meeting

This GRC was held in conjunction with the "Bioanalytical Sensors" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Future for Engineered and Wearable Biology in Bioanalytical Sensors
Discussion Leader: Elizabeth Hall (University of Cambridge, United Kingdom)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmJohn Rogers (University of Illinois, USA)
"Epidermal Electronic Systems"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:10 pmJames Ajioka (University of Cambridge, United Kingdom)
"Development of a Whole-Cell Arsenic Biosensor for Field Use in Nepal and Bangladesh"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthetic Biology: Analytical Challenges and Unusual Opportunities
Discussion Leader: James Ajioka (University of Cambridge, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amMaarten Merkx (Eindhoven University of Technology, The Netherlands)
"Engineering Intelligent Biomolecular Switches for Antibody Detection and Actuation"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amDavid Riglar (Harvard Medical School, USA)
"Gut Feelings: Engineering Bacterial Circuits to Probe Inflammation in the Mammalian Gut"
10:25 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:30 amKevin Plaxco (University of California, Santa Barbara, USA)
"An Aptamer-Based Approach to Continuous, Real-Time Molecular Measurements In Vivo"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmDonglei (Emma) Fan (University of Texas at Austin, USA)
"Robotic Nanomotor Platform for Enhanced Biosensing and Molecule Release"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrom Material to Sensing
Discussion Leader: Kevin Plaxco (University of California, Santa Barbara, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmXiaolei Zuo (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China)
"3-Dimensional DNA Probes Decorated Biosensing Interface"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmSapna Deo (University of Miami, USA)
"Engineering and Exploiting Biological Recognition for Biosensing and Targeted Delivery Applications"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMicroanalytical: Spectroscopy and Spectrometry
Discussion Leader: Susan Lunte (The University of Kansas, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amJin-Ming Lin (Tsinghua University, China)
"Cells Co-Cultured on a Microfluidic Device and Analysis with Mass Spectrometry"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amPawel Urban (National Chiao Tung University, Taiwan)
"Topical Drug Analysis/Imaging Using Mass Spectrometry and Related Topics"
10:25 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:30 amKaren Faulds (University of Strathclyde, United Kingdom)
"Sensitive and Multiplexed Bioanalysis by SERS"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmThomas Meade (Northwestern University, USA)
"Probing Weak Interactions with Transition Metal Reporters"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIn Vitro and In Vivo Sensing and Imaging
Discussion Leader: Robin McCarley (Louisiana State University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmGabi Kaminski-Schierle (University of Cambridge, United Kingdom)
"In Situ Studies of Protein Aggregation Kinetics Applying Multiparametric and Superresolution Imaging"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmElizabeth Hillman (Columbia University, USA)
"Imaging In-Vivo Functional Dynamics at High Spatiotemporal Resolution"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicrosystems: Molecular or Cellular?
Discussion Leader: Duncan Graham (University of Strathclyde, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amThomas Burg (Max Planck Institute for Biophysical Chemistry, Germany)
"Microdevices for Molecular Measurements and Cryo-Microscopy at the Nanoscale"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amPallavi Dhagat (Oregon State University, USA)
"Magnetic Particle Imaging at the Cellular Level"
10:25 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:30 amPetra Dittrich (ETH Zurich, Switzerland)
"Cell-Derived Vesicles on Microfluidic Platforms: New Sensors for Pharmaceutical and Diagnostic Applications"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmRobert Soto (University of North Carolina at Chapel Hill, USA)
"Subcutaneous Tissue Biocompatibility of Implanted Electrochemical Glucose Biosensors"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDetection Platforms: System or Application
Discussion Leader: Gillian Greenway (University of Hull, United Kingdom)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmDaniel Citterio (Keio University, Japan)
"Printed Paper-Based Devices for On-Site Low-Cost Diagnostics"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmAntje Baeumner (University of Regensburg, Germany)
"Bioanalytical Microsystems for the Detection of Pathogenic Organisms"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWhere Is the Future?
Discussion Leader: Antje Baeumner (University of Regensburg, Germany)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amJenny Emneus (Technical University of Denmark, Denmark)
"Microfluidic Lab-on-a-Chips for Biosensing Applications"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amCullen Buie (Massachusetts Institute of Technology, USA)
"Microfluidic Genetic Transformation Platforms for Synthetic Biology and Microbial Biotechnology"
10:25 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:30 amMargaret Frey (Cornell University, USA)
"Electrospun Nanofibers for Analyte Purification"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSridhar Iyengar (Elemental Machines, Misfit Wearables, USA)
"Connected Sensors: How Is IoT Transforming Healthcare/Life Science?"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmYoung Investigator Presentations
The most exciting topics selected from the posters presented during the week.
Discussion Leader: Andre Adams (Naval Research Laboratory, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 7:55 pmGary Abel (University of California, Merced, USA)
"Single-Molecule Insights into DNA Sensors with Atomic Force Microscopy"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmWestley Bauer (Vanderbilt University, USA)
"Multiplex Biomarker Capture-Andrelease Reagents for the Enhancement of Malaria Rapid Diagnostic Tests"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmFabio Del Ben (CRO Aviano, Italy)
"A Microfluidic Approach to Single Cell Metabolism Determination, as a Basis for Circulating Tumor Cells Detection"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmHeather Robison (University of Illinois at Urbana-Champaign, USA)
"Multiplexed Cytokine-Chemokine Profiling Using Microring Resonator Arrays to Diagnose Latent Tuberculosis Infection"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmKentaro Yamada (Keio University, Japan)
"Color Printing for Text-Displayed Colorimetry on Paper-Based Analytical Devices"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13EB022399-01 from the National Institute of Biomedical Imaging and Bioengineering. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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