Applications for this meeting must be submitted by May 6, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 3, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).
The Gordon Research Seminar on CAG Triplet Repeat Disorders is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of
the this GRS is to bring together young scientists from around the world to
present and discuss their recent findings on the mechanisms of pathology
underlying CAG triplet repeat disorders, as well as on advancements in how to
combat these diseases. The meeting will feature a keynote presentation, data
presentations from young scientists, and poster presentations. Throughout the
meeting, attendees will have the opportunity to engage with peers and discuss
different career options while networking with mentors from academia and
The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.
The Chairs will select speakers from abstracts submitted by March 3, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.
This GRS will be held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Conference (GRC)
. Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page
for more information.
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: A Scientific Journey: Passion, Flexibility and Collaboration|
|Discussion Leader: Philipp Trepte (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)|
|3:45 pm - 4:20 pm||Leslie Thompson (University of California, Irvine, USA)|
"A Scientific Journey: Passion, Flexibility and Collaboration"
|4:20 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Emerging
Methods and Models: Illuminating New Paths to Therapeutics|
|Discussion Leader: Shyam Ramachandran (Children's Hospital of Philadelphia, USA)|
|7:30 pm - 7:50 pm||Rana Soylu-Kucharz (Lund University, Sweden)|
"Striatal Neuropathology Induced by Hypothalamic Overexpression of Huntingtin Fragments Using Adeno-Associated Viral Vectors in Mice"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Lauren Byrne (UCL Huntington's Disease Centre, United Kingdom)|
"Towards a Readily Accessible Biofluid Biomarker for Huntington's Disease"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Pamela Farshim (University College London, United Kingdom)|
"Systemic Administration of a Novel AAV Variant Results in Widespread and Efficient Gene Transfer in R6/2 Mice"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Daniel Child (The Children's Hospital of Philadelphia, USA)|
"Abnormal Cardiac mTORC1 Activity in Huntington Disease Mouse Models"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Molecular
Mechanisms of Disease|
|Discussion Leader: Gunasekhar Burra (Indian Institute of Technology Kanpur, India)|
|9:00 am - 9:20 am||Anne Steinhof (Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Germany)|
"Mutant HTT Seeding Activity: A Marker of Disease Progression in Models of Huntington's Disease"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Samir Nath (University of Michigan, USA)|
"Proteasome Dysregulation in Spinobulbar Muscular Atrophy"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Charlene Geater (University of California, Irvine, USA)|
"Huntington's Disease in a Dish"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Radhia Kacher (CNRS / Pierre and Marie Curie University, France)|
"zQ175 Knock-In Mouse Model Helps to Decipher the Neuroprotective Role of CYP46A1, the Cholesterol Degradation Enzyme, in Huntington's Disease"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Pathophysiology
|Discussion Leader: Sarah Gardiner (Leiden University Medical Centre, The Netherlands)|
|1:30 pm - 1:45 pm||Frederick Arnold (Thomas Jefferson University, USA)|
"Deficient Nuclear Export of Polyglutamine-Expanded Androgen Receptor Contributes to Toxicity in a Cell Model of Spinal and Bulbar Muscular Atrophy"
|1:45 pm - 1:50 pm||Discussion|
|1:50 pm - 2:05 pm||Anastasia Gromova (University of California, San Diego, USA)|
"Elucidating Mechanisms of Skeletal Muscle-Driven Neurodegeneration in Spinal and Bulbar Muscular Atrophy"
|2:05 pm - 2:10 pm||Discussion|
|2:10 pm - 2:25 pm||Nikhil Ratna (National Institute of Mental Health and Neurosciences, India)|
"Lithium in Huntington's Disease"
|2:25 pm - 2:30 pm||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|