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Polyamines (GRS)
Gordon Research Seminar

Polyamines - Mechanistic Insights and Their Therapeutic Applications

Dates

June 24-25, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chairs:
Helen L. Lightfoot & Hayley C. Affronti

Application Deadline

Applications for this meeting must be submitted by May 27, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by April 20, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).

Meeting Description

Overview

The 2017 Gordon Research Seminar (GRS) on Polyamines is an exclusive meeting for graduate students, post-doctoral scholars and other early stage researchers with similar education and experiences. Here scientists exchange new data and cutting edge ideas, as well as foster scientific collaborations. During the GRS, scientists are encouraged to interact with invited renowned group leaders in the field prior to the Polyamines GRC. The 2017 GRS program will feature groundbreaking science on the role and regulation of polyamines, and their therapeutic application as either targets or agents.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by April 20, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Polyamines" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmPolyamine Metabolism - Mechanistic Insights
Discussion Leader: Anthony Pegg (Pennsylvania State University College of Medicine, USA)
3:45 pm - 3:50 pmIntroduction by Discussion Leader
3:50 pm - 4:05 pmMarie Mooney (Michigan State University, USA)
"Novel Interaction Between Ornithine Decarboxylase and Sepiapterin Reductase"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmTiffany Lowe-Power (University of Wisconsin-Madison, USA)
"How Putrescine Increases Host Susceptibility to the Plant Pathogenic Bacterium Ralstonia solanacearum"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFunctions of Cellular Polyamines
Discussion Leader: Myung-Hee Park (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 7:55 pmYuri Ishii (Kwansei Gakuin University, Japan)
"Polyamines in Vinegar Are Key Compounds for Effective Trapping of the Spotted Wing Drosophilia"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMarta Maglione (Freie Universitat Berlin, Germany)
"Understanding the Neurobiological Mechanism Underlying Age-Dependent Memory Impairment (AMI) and the Basic Protective Effects of the Polyamine Spermidine"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmVladimir Valuev-Elliston (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russia)
"Role of Polyamine in Endothelial-Mesenchymal Transition (EMT) in Liver Cells"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmMichelle Olsen (National Emerging Infectious Diseases Laboratories, Boston University, USA)
"Polyamines and Hypusinated eIF5A Are Required for Ebolavirus Gene Expression and Replication"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmTahira Fatima (Purdue University, USA)
"Higher 'Spermidine+Spermine/Putrescine' Ratio in Transgenic Tomato Correlates with Higher Content of Flavonoids Beneficial for Human Health and Defense"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPolyamines in Therapeutics - As Targets and Agents
Discussion Leader: Otto Phanstiel (University of Central Florida, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:25 amSpencer Rosario (Roswell Park Cancer Institute, USA)
"Identification of Metabolic Pathways Dysregulated in Prostate Cancer and the Master Regulators of These Pathways"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amAndrea Flynn (Children's Hospital of Philadelphia, USA)
"Difluoromethylornithine (DFMO) Inhibits Global Protein Translation and Has Anti-Tumor Activity in Neuroblastoma"
9:50 am - 9:55 amDiscussion
9:55 am - 10:10 amSteven Holshouser (Medical University of South Carolina, USA)
"Design and Synthesis of Novel, Potent Polyamine Oxidase Family Inhibitors as Efficacious Agents in Pancreatic Cancer"
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amDirk Geerts (Erasmus University Medical Center, The Netherlands)
"Bio-Informatics and HT RNAi on PA Pathway Genes in Cancer and Other Diseases"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amManuela Cervelli (Roma Tre University, Italy)
"Molecular Mechanisms Involved in Glutamate Excitotoxicity Linked to Spermine Oxidase"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmKeynote Session: Polyamines in Therapeutics
Discussion Leader: Robert Casero (Johns Hopkins University School of Medicine, USA)
1:30 pm - 2:20 pmOtto Phanstiel (University of Central Florida, USA)
"Polyamines in Therapeutics"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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