Gordon Research Conferences
Meeting Details

Polyamines (GRS)
Gordon Research Seminar

Polyamines - Mechanistic Insights and Their Therapeutic Applications


June 24-25, 2017


Waterville Valley
Waterville Valley, NH


Helen L. Lightfoot & Hayley C. Affronti

Meeting Description

The 2017 Gordon Research Seminar (GRS) on Polyamines is an exclusive meeting for graduate students, post-doctoral scholars and other early stage researchers with similar education and experiences. Here scientists exchange new data and cutting edge ideas, as well as foster scientific collaborations. During the GRS, scientists are encouraged to interact with invited renowned group leaders in the field prior to the Polyamines GRC. The 2017 GRS program will feature groundbreaking science on the role and regulation of polyamines, and their therapeutic application as either targets or agents.

Related Meeting

This GRS was held in conjunction with the "Polyamines" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmPolyamine Metabolism - Mechanistic Insights
Discussion Leader: Anthony Pegg (Pennsylvania State University College of Medicine, USA)
3:45 pm - 3:50 pmIntroduction by Discussion Leader
3:50 pm - 4:05 pmMarie Mooney (Michigan State University, USA)
"Novel Interaction Between Ornithine Decarboxylase and Sepiapterin Reductase"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmManuela Cervelli (Roma Tre University, Italy)
"Molecular Mechanisms Involved in Glutamate Excitotoxicity Linked to Spermine Oxidase"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFunctions of Cellular Polyamines
Discussion Leader: Myung-Hee Park (National Institute of Dental and Craniofacial Research, NIH, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 7:55 pmYuri Ishii (Kwansei-Gakuin University, Japan)
"Polyamines in Vinegar Are Key Compounds for Effective Trapping of the Spotted Wing Drosophila"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMarta Maglione (Freie Universitat Berlin, Germany)
"Spermidine Protects from Age-Dependent Structural and Functional Changes at Hippocampal Synapses"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmTahira Fatima (Purdue University, USA)
"Higher 'Spermidine+Spermine/Putrescine' Ratio in Transgenic Tomato Correlates with Higher Content of Flavonoids Beneficial for Human Health and Defense"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmVladimir Valuev-Elliston (Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Russia)
"Role of Polyamine in Endothelial-Mesenchymal Transition (EMT) in Liver Cells"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmIti Mehta (University of Texas at Dallas, USA)
"The Putrescine Requirement for Escherichia coli Swarming Motility"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPolyamines in Therapeutics - As Targets and Agents
Discussion Leader: Otto Phanstiel (University of Central Florida, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:25 amMichelle Olsen (National Emerging Infectious Diseases Laboratories, Boston University, USA)
"Polyamines and Hypusinated eIF5A Are Required for Ebolavirus Gene Expression and Replication"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amAndrea Flynn (Children's Hospital of Philadelphia, USA)
"Difluoromethylornithine (DFMO) Inhibits Global Protein Translation and Has Anti-Tumor Activity in Neuroblastoma"
9:50 am - 9:55 amDiscussion
9:55 am - 10:10 amSpencer Rosario (Roswell Park Cancer Institute, USA)
"In Silico Identification of Polyamine Metabolic Dysregulation Across Cancers"
10:10 am - 10:15 amDiscussion
10:15 am - 10:30 amNathan Sunada (Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, USA)
"Polyamines Regulate Neuroblastoma Progression Through a Mechanism that Involves TRPM7"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amSteven Holshouser (Medical University of South Carolina, USA)
"Design and Synthesis of Novel, Potent Polyamine Oxidase Family Inhibitors as Efficacious Agents in Pancreatic Cancer"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmKeynote Session: Polyamines in Therapeutics
Discussion Leader: Robert Casero (Johns Hopkins University School of Medicine, USA)
1:30 pm - 2:20 pmOtto Phanstiel (University of Central Florida, USA)
"Polyamines in Therapeutics"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13CA216980-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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