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Bioinorganic Chemistry (GRS)
Gordon Research Seminar

Exploring All Facets of the Inorganic Chemistry of Life

Dates

January 28-31, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Kelly Chacon

Vice Chair:
Lauren J. Rajakovich

Meeting Description

The Bioinorganic Chemistry Gordon Research Seminar (GRS) is actually the first GRS to have been created, in 1996, and serves as a student and postdoctoral extension of its parent Metals in Biology Gordon Research Conference (GRC). As the first GRS, it is unique in that it shares an evening session with the Metals in Biology conference, with a joint evening lecture and poster session that allows for valuable interaction between students, postdocs, and established leaders in the field.

The success of the Metals in Biology GRC has resulted in consistent oversubscription, which has in turn led to attendance at the Bioinorganic Chemistry GRS being even more highly sought after by students and postdocs. This creates an extremely vibrant and constantly evolving meeting, which can be counted upon to keep attendees on the cutting edge of new developments in the field, every single year. This year we are continuing this evolution of new ideas and contributions, and will truly be exploring all facets of the inorganic chemistry of life.

Bioinorganic chemistry encompasses a wide range of topics including metalloprotein structure and reactivity, metal transport and homeostasis, metals in the environment, and bioinorganic technique and application development. We invite and encourage students from any sub-discipline in Bioinorganic Chemistry to submit abstracts for poster or oral presentations. Questions may be directed to the 2016 Chair, Kelly Chacón, or to the 2016 Vice Chair, Lauren Rajakovich.

This year we would also like to encourage all GRS attendees to consider bringing their own reusable coffee mug, so as to reduce paper waste.

Related Meeting

This GRS was held in conjunction with the "Metals in Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Thursday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 9:30 pmJoint Session with the Metals In Biology GRC: RNRs Diverse Metallo-Cofactors Essential Deoxynucleotide Biosynthesis
Discussion Leader: Joseph Martin Bollinger (Pennsylvania State University, USA)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:15 pmAmie Boal (Pennsylvania State University, USA)
"Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmBritt-Marie Sjoberg (Stockholm University, Sweden)
"On the Evolution of Ribonucleotide Reductases"
9:15 pm - 9:30 pmDiscussion
9:30 pmJoint Poster Session with Metals in Biology GRC
Friday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCritical Condition: Metals in Human Health and the Environment
Discussion Leader: Ingrid Pickering (University of Saskatchewan, Canada)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amMatthew Edmundson (University of Edinburgh, United Kingdom)
"Contaminated Land as a Source of Metals for Bacterial Nanoparticle Production, Utilizing Synthetic Biology"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amRodrigo Galindo (University of Utah, USA)
"Elucidating Copper Based Drug Induced DNA Base-Pair Eversion"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amErica Majumder (University of Missouri, USA)
"Involvement of Thioredoxins from Sulfate Reducing Bacteria in Heavy Metal Reduction"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amKelly Summers (University of Saskatchewan, Canada)
"Synchrotron Light in the Study of Alzheimer's Disease: Illuminating the Mechanism of Action of 8-Hydroxyquinoline Drugs"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amGeorge Cutsail (Max Planck Institute for Chemical Energy Conversion, Germany)
"Understanding Biological Oxygen Activation for the Generation of Liquid Fuels"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmDarrell Martin (Texas A&M University, USA)
"A Class of Its Own: HydY from C. symbiosum Is a H2-Uptake Biased H2O2 Reductase"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNavigating the Landscape: Structure, Folding, and Thermodynamics
Discussion Leader: Liliya Yatsunyk (Swarthmore College, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmJennifer Bridwell-Rabb (Massachusetts Institute of Technology, USA)
"A Crystallographic Detective Story: Elucidation of the Oxetanocin Biosynthetic Pathway"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAndrew Mitchell (The Pennsylvania State University, USA)
"Structural Basis for Selective Chlorination by the Iron-/2-Oxo-Glutarate-Dependent Halogenase WelO5"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLeiah Carey (North Carolina State University, USA)
"X-Ray Crystallographic Studies of Substrate Binding to Dehaloperoxidase from Amphitrite Ornata"
8:50 pm - 8:55 pmDiscussion
Data Blitz
8:55 pm - 9:00 pmAmanda Baum (Marquette University, USA)
"Biologically Relevant Fe(II) Complexes Containing Redox Active (Hydro)Quinone Ligands"
9:00 pm - 9:05 pmKarla Ramos-Torres (University of California, Berkeley, USA)
"Novel Receptor Platforms for Biological Cu(I) Sensing"
9:05 pm - 9:10 pmSeth Cory (Texas A&M University, USA)
"Crystal Structure of Eukaryotic Cysteine Desulfurase"
9:10 pm - 9:15 pmNirupama Singh (University of Alabama in Huntsville, USA)
"Bioinspired Nickel and Copper Complexes to Explore Dioxygen Activation Chemistry"
9:15 pm - 9:20 pmChristine Romano (Oregon Health and Science University, USA)
"Mnx, the Mn(II)-Oxidizing Multicopper Oxidase Complex from Bacillus sp. PL-12"
9:20 pm - 9:30 pmGeneral Discussion
Saturday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAchieving Balance: Homeostasis, Transport, and Biogenesis
Discussion Leader: David Giedroc (Indiana University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amArianna Celis Luna (Montana State University, USA)
"The Last Stop on a New Road to Heme"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amCarolyn Carr (University of Massachusetts Amherst, USA)
"Differential Role of Glutamate Ligands During Metal Response in the E. coli Transcriptional Regulator, RcnR"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amRoma Mukhopadhyay (New Mexico State University, USA)
"A Redox Sensing Function for the Heme Nitric Oxide/Oxygen Binding Protein (H-NOX) from Vibrio cholerae that Is Independent of Heme Binding."
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amMichael Lacasse (University of Toronto, Canada)
"Selective Nickel Transfer Between [NiFe] Hydrogenase Maturation Proteins HypB and HypA"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amStephen Dzul (Wayne State University, USA)
"In Vitro Characterization of a Novel Primary Scaffold Homologue for De Novo Fe-S Cluster Formation from Drosophila melanogaster"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmRachel Johnson (East Carolina University, USA)
"Quantifying the Thermodynamics that Define Calcium Selectivity: A Comparison to Cadmium"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmFitting the Curve: Spectroscopy, Kinetics, and Computation
Discussion Leader: R. David Britt (University of California, Davis, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmMatthew Conger (University of Vermont, USA)
"Second-Sphere Pertubation of IsdG Modulates the Spin Density Distribution of the Heme Substrate"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmLizhi Tao (University of California, Davis, USA)
"Mn(II) Oxidation by Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBo Zhang (The Pennsylvania State University, USA)
"Mechanism of Arylamine N-Oxygenation by the (Hydro)Peroxo-Fe2(III/III) Intermediate in AurF from Streptomyces thioluteus"
8:50 pm - 8:55 pmDiscussion
Data Blitz
8:55 pm - 9:00 pmSubrata Kundu (Georgetown University, USA)
"Mechanistic Insights into NO to N2O Transformation at a Mononuclear Nickel Site"
9:00 pm - 9:05 pmKanchana Ravichandran (Massachusetts Institute of Technology, USA)
"Investigating the Thermodynamic Landscape of the Proton-Coupled Electron Transfer Pathway in Ribonucleotide Reductase Using a Fluorotyrosyl Radical Initiator"
9:05 pm - 9:10 pmSabine Studer (ETH Zürich, Switzerland)
"Directed Evolution of a Small Artificial Metalloprotein"
9:10 pm - 9:15 pmAmanda Vo (Boston University, USA)
"Reconstitution of the Cytosolic Iron-Sulfur Assembly Targeting Complex for Target Recognition"
9:15 pm - 9:20 pmVanessa Chaplin (University of Massachusetts Amherst, USA)
"Manipulating Catalytic Activity of HIF Hydroxylases to Control the Hypoxic Response"
9:20 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Highest Form of Flattery: Bioinspiration and Synthetic Chemistry
Discussion Leader: Carsten Krebs (Pennsylvania State University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amLee Solomon (Argonne National Laboratory, USA)
"Expanding Peptide Amphiphile Functions to Energy and Electrchemical Applications"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amChristian Tooley (University of New Hampshire, USA)
"Stoichiometric Covalent Binding of Model Diiron Complexes to Polymer Chains"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amBenjamin Lin (Harvard University, USA)
"Targeting Reactive Polynuclear Clusters"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amLewis Churchfield (University of California, San Diego, USA)
"Engineered Metalloprotein Scaffolds Exert Tunable Outer-Sphere Effects on Internalized Metals via Disulfide Bond Networks"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amRamsey Steiner (University of Georgia, USA)
"Assessing Potential Mechanisms of Thiolate Protection with Multimetallic Model Complexes of NiSOD"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmSamuel Mann (University of California, Irvine, USA)
"Artificial Metalloproteins: Towards a Blue Copper Center"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pmDeparture
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