Applications for this meeting must be submitted by May 27, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
GRS Speaker Abstract Deadline: Although applications will be accepted until the date noted above, any applicants who wish to be considered for an oral presentation should submit their application by March 24, 2017. Please refer to the application instructions in the Meeting Description section below for more details (if available).
The Gordon Research Seminar on High Throughput Chemistry and Chemical Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The focus of this meeting is on chemical approaches to elucidating and solving outstanding problems in biomedicine. We will discuss recent advances in synthetic, medicinal, and analytical chemistry that enable the structures and functions of molecules of therapeutic interest to be detected, probed, and modulated selectively in model systems. We will also concentrate on recent advances in drug discovery that could help translate these insights into powerful therapeutics. Our keynote speaker will be Prof. Emily Balskus from Harvard University.
The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.
The Chairs will select speakers from abstracts submitted by March 24, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.
This GRS will be held in conjunction with the "High Throughput Chemistry & Chemical Biology" Gordon Research Conference (GRC)
. Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page
for more information.
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Advances in Chemical Biology|
|Discussion Leader: Elizabeth Parkinson (University of Illinois at Urbana-Champaign, USA)|
|3:45 pm - 4:25 pm||Emily Balskus (Harvard University, USA)|
"Exploring the Interface of Chemistry and Microbiology"
|4:25 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Advances in Compound Library Design, Generation, and Utilization|
|Discussion Leader: Sarah Tasker (University of Illinois at Urbana-Champaign, USA)|
|7:30 pm - 7:45 pm||Camille Villequey (École Polytechnique Fédérale de Lausanne (EPFL), Switzerland)|
"Expanding Chemical and Structural Diversity of Phage-Encoded Macrocyclic Peptide Libraries"
|7:45 pm - 7:50 pm||Discussion|
|7:50 pm - 8:05 pm||Naoko Ichiishi (Merck & Co., Inc., USA)|
"Use of High Throughput Experimentation to Develop Enabling Late Stage Functionalization Approaches for Chemical Biology Applications"
|8:05 pm - 8:10 pm||Discussion|
|8:10 pm - 8:25 pm||Jon Bogart (University of North Carolina at Chapel Hill, USA)|
"A Chemoenzymatic Platform for the Discovery of Thiopeptide Therapeutics"
|8:25 pm - 8:30 pm||Discussion|
|8:30 pm - 8:45 pm||Alix Chan (Harvard University, USA)|
"Discovery of Bioactive Small Molecules from a DNA-Encoded Library x Library Selection"
|8:45 pm - 8:50 pm||Discussion|
|8:50 pm - 9:05 pm||Carlos Moreno-Yruela (University of Copenhagen, Denmark)|
"Peptide Arrays Bearing Zinc-Binding Groups for the Investigation of Human Histone Deacetylases"
|9:05 pm - 9:10 pm||Discussion|
|9:10 pm - 9:30 pm||General Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Development of Chemical Probes and Therapeutics|
|Discussion Leader: Justin Rettenmaier (Whitehead Institute for Biological Research, USA)|
|9:00 am - 9:15 am||Juliane Totzke (Duke University, USA)|
"EDHS-206, a Potent and Selective Inhibitor of TAK1, Targets Pro Survival TNFa Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Models"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:35 am||Zachary Hill (University of California, San Francisco, USA)|
"Probing the Ligandable Surface of PTP1B Through Tethering-Based Ligand Scanning"
|9:35 am - 9:40 am||Discussion|
|9:40 am - 9:55 am||Markus Lakemeyer (Technical University of Munich, Germany)|
"Probing the Oligomeric Assembly and Catalytic Activity of S. aureus ClpP Using Small Molecules"
|9:55 am - 10:00 am||Discussion|
|10:00 am - 10:15 am||Chunyan Ren (Icahn School of Medicine at Mount Sinai, USA)|
"Structural-Based Design of Epigenetic Chemical Modulators for CBX7 Chromodomain"
|10:15 am - 10:20 am||Discussion|
|10:20 am - 10:35 am||Christoph Grohmann (Walter and Eliza Hall Institute of Medical Research, Australia)|
"Chemoproteomic Approach to Identify a Novel Effector of the Necroptotic Signaling Pathway Downstream of MLKL"
|10:35 am - 10:40 am||Discussion|
|10:40 am - 11:00 am||General Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Chemoproteomics for Novel Target Identification|
|Discussion Leader: David Montgomery (National Cancer Institute, NIH, USA)|
|1:30 pm - 1:45 pm||Rhushikesh Kulkarni (National Cancer Institute, NIH, USA)|
"Chemoproteomic Portrait of the Oncometabolite Fumarate"
|1:45 pm - 1:50 pm||Discussion|
|1:50 pm - 2:05 pm||Christopher Parker (The Scripps Research Institute, USA)|
"Ligand and Target Discovery by Fragment-Based Screening in Human Cells"
|2:05 pm - 2:10 pm||Discussion|
|2:10 pm - 2:30 pm||General Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|