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High Throughput Chemistry & Chemical Biology (GRS)
Gordon Research Seminar

Chemistry Enabling Advances and Discoveries in Biology and Medicine

Dates

June 24-25, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chairs:
Elizabeth I. Parkinson & Cynthia M. Chio

Application Deadline

The application deadline for this meeting was May 27, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

Overview

The Gordon Research Seminar on High Throughput Chemistry and Chemical Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on chemical approaches to elucidating and solving outstanding problems in biomedicine. We will discuss recent advances in synthetic, medicinal, and analytical chemistry that enable the structures and functions of molecules of therapeutic interest to be detected, probed, and modulated selectively in model systems. We will also concentrate on recent advances in drug discovery that could help translate these insights into powerful therapeutics. Our keynote speaker will be Prof. Emily Balskus from Harvard University.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by March 24, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "High Throughput Chemistry & Chemical Biology" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Advances in Chemical Biology
Discussion Leader: Elizabeth Parkinson (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:25 pmEmily Balskus (Harvard University, USA)
"Deciphering the Human Microbiome with Chemistry"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Compound Library Design, Generation, and Utilization
Discussion Leader: Sarah Tasker (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pmCamille Villequey (École Polytechnique Fédérale de Lausanne (EPFL), Switzerland)
"Expanding Chemical and Structural Diversity of Phage-Encoded Macrocyclic Peptide Libraries"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmNaoko Ichiishi (Merck & Co., Inc., USA)
"Use of High Throughput Experimentation to Develop Enabling Late Stage Functionalization Approaches for Chemical Biology Applications"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJon Bogart (University of North Carolina at Chapel Hill, USA)
"A Chemoenzymatic Platform for the Discovery of Thiopeptide Therapeutics"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmAlix Chan (Harvard University, USA)
"Discovery of Bioactive Small Molecules from a DNA-Encoded Library x Library Selection"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmCarlos Moreno-Yruela (University of Copenhagen, Denmark)
"Peptide Arrays Bearing Zinc-Binding Groups for the Investigation of Human Histone Deacetylases"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amDevelopment of Chemical Probes and Therapeutics
Discussion Leader: Justin Rettenmaier (Whitehead Institute for Biological Research, USA)
9:00 am - 9:15 amJuliane Totzke (Duke University, USA)
"EDHS-206, a Potent and Selective Inhibitor of TAK1, Targets Pro Survival TNFa Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Models"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amZachary Hill (University of California, San Francisco, USA)
"Probing the Ligandable Surface of PTP1B Through Tethering-Based Ligand Scanning"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMarkus Lakemeyer (Technical University of Munich, Germany)
"Probing the Oligomeric Assembly and Catalytic Activity of S. aureus ClpP Using Small Molecules"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amChunyan Ren (Icahn School of Medicine at Mount Sinai, USA)
"Structural-Based Design of Epigenetic Chemical Modulators for CBX7 Chromodomain"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amChristoph Grohmann (Walter and Eliza Hall Institute of Medical Research, Australia)
"Chemoproteomic Approach to Identify a Novel Effector of the Necroptotic Signaling Pathway Downstream of MLKL"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmChemoproteomics for Novel Target Identification
Discussion Leader: Evijola Llabani (University of Illinois at Urbana-Champaign, USA)
1:30 pm - 1:45 pmRhushikesh Kulkarni (National Cancer Institute, NIH, USA)
"Chemoproteomic Portrait of the Oncometabolite Fumarate"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmDavid Montgomery (National Cancer Institute, NIH, USA)
"Profiling the Role of Catalytic Acetylation in Oncogene Signaling"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:30 pmGeneral Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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