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High Throughput Chemistry and Chemical Biology (GRS)
Gordon Research Seminar

Chemistry Enabling Advances and Discoveries in Biology and Medicine

Dates

June 24-25, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Elizabeth I. Parkinson & Cynthia M. Chio

Meeting Description

The Gordon Research Seminar on High Throughput Chemistry and Chemical Biology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on chemical approaches to elucidating and solving outstanding problems in biomedicine. We will discuss recent advances in synthetic, medicinal, and analytical chemistry that enable the structures and functions of molecules of therapeutic interest to be detected, probed, and modulated selectively in model systems. We will also concentrate on recent advances in drug discovery that could help translate these insights into powerful therapeutics. Our keynote speaker will be Prof. Emily Balskus from Harvard University.

Related Meeting

This GRS was held in conjunction with the "High Throughput Chemistry and Chemical Biology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Advances in Chemical Biology
Discussion Leader: Elizabeth Parkinson (University of Illinois at Urbana-Champaign, USA)
3:45 pm - 4:25 pmEmily Balskus (Harvard University, USA)
"Deciphering the Human Microbiome with Chemistry"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvances in Compound Library Design, Generation, and Utilization
Discussion Leader: Sarah Tasker (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pmCamille Villequey (École Polytechnique Fédérale de Lausanne (EPFL), Switzerland)
"Expanding Chemical and Structural Diversity of Phage-Encoded Macrocyclic Peptide Libraries"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmNaoko Ichiishi (Merck & Co., Inc., USA)
"Use of High Throughput Experimentation to Develop Enabling Late Stage Functionalization Approaches for Chemical Biology Applications"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJon Bogart (University of North Carolina at Chapel Hill, USA)
"A Chemoenzymatic Platform for the Discovery of Thiopeptide Therapeutics"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmAlix Chan (Harvard University, USA)
"Discovery of Bioactive Small Molecules from a DNA-Encoded Library x Library Selection"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmCarlos Moreno-Yruela (University of Copenhagen, Denmark)
"Interrogating Substrate Specificity of Human Histone Deacetylases Using Peptide Microarrays"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amDevelopment of Chemical Probes and Therapeutics
Discussion Leader: Justin Rettenmaier (Whitehead Institute for Biological Research, USA)
9:00 am - 9:15 amJuliane Totzke (Duke University, USA)
"EDHS-206, a Potent and Selective Inhibitor of TAK1, Targets Pro Survival TNFa Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Models"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amZachary Hill (University of California, San Francisco, USA)
"Probing the Ligandable Surface of PTP1B Through Tethering-Based Ligand Scanning"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMarkus Lakemeyer (Technical University of Munich, Germany)
"Probing the Oligomeric Assembly and Catalytic Activity of S. aureus ClpP Using Small Molecules"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amChunyan Ren (Icahn School of Medicine at Mount Sinai, USA)
"Structural-Based Design of Epigenetic Chemical Modulators for CBX7 Chromodomain"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amDenise Field (Pfizer, USA)
"Selective Downregulation of JAK2 and JAK3 by an ATP-Competitive Pan-JAK Inhibitor"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmAssays for Novel Target Identification
Discussion Leader: Evijola Llabani (University of Illinois at Urbana-Champaign, USA)
1:30 pm - 1:45 pmDylan Mitchell (University of Michigan, USA)
"Leveraging a Novel Activity-Based Probe for the Identification of 4E-BP1 Kinases"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmJonathan Shrimp (National Cancer Institute, NIH, USA)
"CRISPR-Cas9 Profiling of Lysine Acetyltransferase Activity"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:30 pmGeneral Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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