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Microbial Toxins & Pathogenicity (GRS)
Gordon Research Seminar

Defining Pathogenesis and the Host-Microbe Dynamic

Dates

July 9-10, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Aaron T. Whiteley & Cara Mozola Forsberg

Meeting Description

The Gordon Research Seminar on Microbial Toxins and Pathogenicity is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting spotlights the interplay between microbial pathogens and their host including innovative approaches and technologies. Each oral and poster session will convene speakers in diverse areas from immunity to bacterial pathogens and their secreted products in order to drive discussion of the current understanding of molecular mechanisms of disease.

Related Meeting

This GRS was held in conjunction with the "Microbial Toxins & Pathogenicity" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmInvasion and Dissemination of Pathogens
Discussion Leader: Kimberly Davis (Tufts University School of Medicine, USA)
3:45 pm - 3:50 pmOpening Remarks
3:50 pm - 4:05 pmSamantha Prezioso (Emory University, USA)
"Direct and Indirect Impact of EftM on Pseudomonas aeruginosa Adhesion"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmRebeccah Lijek (Harvard Medical School, USA)
"Chlamydia trachomatis Serovar-Specific Virulence Factors Drive Immunopathology"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunity and Inflammation During Infection
Discussion Leaders: Andrew Olive (University of Massachusetts Medical School, USA) and Lillian Juttukonda (Vanderbilt University, USA)
7:30 pm - 7:45 pmJeannette Tenthorey (University of California, Berkeley, USA)
"Recognition of Multiple Motifs on Bacterial Ligands by NAIP Receptors Constrains Bacterial Immune Evasion"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmJonathan Lenz (University of Wisconsin-Madison, USA)
"Role for Neisseria gonorrhoeae LdcA in NOD1-Agonist Peptidoglycan Release and Effects on Inflammatory Responses in Human Blood and Fallopian Tube"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmMariana Byndloss (University of California, Davis, USA)
"PPARγ Signaling Mediates Colonization Resistance Against Escherichia coli"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmTobias Kerrinnes (University of California, Davis, USA)
"Host Cell Polyamine Synthesis Provides a Crucial Nutrient Source for Intracellular Growth and Persistence of Brucella abortus"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMatthew Hendricks (University of Pittsburgh School of Medicine, USA)
"Dysregulation of Nutritional Immunity During Respiratory Virus Infection Enhances Pseudomonas aeruginosa Biofilm Growth"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAimee Wilde (Vanderbilt University, USA)
"Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amSecretion Systems and Maintaining the Replicative Niche
Discussion Leaders: Kate Zulauf (University of North Carolina at Chapel Hill, USA) and Stephanie Shames (Yale University, USA)
9:00 am - 9:15 amAdelle McFarland (University of Washington, USA)
"Cyclic Dinucleotide Detection by RECON Controls Innate Immune Responses"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amBrandon Anjuwon-Foster (University of North Carolina at Chapel Hill, USA)
"A Genetic Switch Controls Flagellum Biosynthesis and Toxin Production in Clostridium difficile"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJames Grayczyk (Loyola University Chicago, USA)
"Staphylococcus aureus Suppression of Immune Responses via Metabolic Cofactors"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amTroy Hubbard (Harvard Medical School, USA)
"Genetic Analysis of Vibrio parahaemolyticus Intestinal Colonization"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amBrian Russo (Massachusetts General Hospital, USA)
"Intermediate Filaments Enable Pathogen Docking to Trigger Type 3 Effector Translocation"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amKristin Kotewicz (Sackler School of Graduate Biomedical Sciences, Tufts University, USA)
"L. pneumophila Remodels Host ER Tubules via Bacterial Ubiquitin Editing Proteins"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMicrobial Toxins
Discussion Leader: Walter Adams (Tufts University, USA)
1:30 pm - 1:50 pmDivya Balasubramanian (New York University School of Medicine, USA)
"Staphylococcus aureus Coordinates Leukocidin Expression and Pathogenesis by Sensing Metabolic Fluxes"
1:50 pm - 1:55 pmDiscussion
1:55 pm - 2:15 pmLaura Ristow (University of Wisconsin-Madison, USA)
"Identification of a Host Receptor for Hemolysin from Uropathogenic Escherichia coli"
2:15 pm - 2:20 pmDiscussion
2:20 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible in part by 1 R13 AI124475-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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