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Hemostasis (GRS)
Gordon Research Seminar

Coagulation, Platelet Biology, and Inflammation

Dates

July 23-24, 2016

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
Leila Noetzli & Carleigh F. Hebbard

Meeting Description

The Gordon Research Seminar (GRS) on Hemostasis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The GRS is a small group setting that fosters open discussion about innovative research through formal presentation and social interaction. The Hemostasis GRS will cover topics related to hemostasis and thrombosis, platelet and megakaryocyte biology, therapeutics, and the role of hemostatic and thrombotic processes in sepsis and inflammation. The GRS will also feature a career panel session during which mentors at various stages of their careers will share experiences and answer career-focused questions from the trainees. The Hemostasis GRS will be held in conjunction with the Gordon Research Conference on Hemostasis, and we encourage applicants to submit abstracts to both meetings.

Related Meeting

This GRS was held in conjunction with the "Hemostasis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Exploring the Multiple Career Pathways in Blood Research
Discussion Leaders: Carleigh Hebbard (University of Illinois at Urbana-Champaign, USA) and Matthew Rondina (University of Utah, USA)
3:45 pm - 4:20 pmJose Lopez (Bloodworks Northwest Research Institute, USA)
"Exploring the Multiple Career Pathways in Blood Research"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Developments in Coagulation: Relevance to Therapeutics
Discussion Leaders: Laura Haynes (University of Vermont, USA) and Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:45 pmFrancis Ayombil (University of Vermont, USA)
"GPI-Anchored, Platelet-Derived Factor Va: Characterization of Its Total Resistance to Proteolytic Inactivation"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmJames Byrnes (University of North Carolina at Chapel Hill, USA)
"The Interaction Between Fibrinogen and Zymogen FXIII-A2B2 Is Mediated by Fibrinogen Residues γ390-396 and the FXIII-B Subunits"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAdam Miszta (Maastricht University, The Netherlands)
"Thrombin-Dependent Incorporation of von Willebrand Factor into a Fibrin Network"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmJamie O'Sullivan (Trinity College, Dublin, Ireland)
"N-Linked Glycans at N1515 and N1574 Within the A2 Domain of VWF Play a Critical Role in Modulating Macrophage-Mediated Clearance"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmYuhang Zhou (Thomas Jefferson University, USA)
"TULA-2 Inhibits FcgammaRIIA-Syk Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMichel Smeets (Sanquin Research, The Netherlands)
"Platelet-Independent Binding of Erythrocytes to von Willebrand Factor"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPlatelets, Megakaryocytes, and Their Function Beyond Hemostasis / Mentorship Component: Career Panel
Discussion Leaders: Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA) and Leila Noetzli (University of Colorado Denver, USA)
9:00 am - 9:15 amCaterina Casari (University of North Carolina at Chapel Hill, USA)
"Protein Kinase C Signaling Dysfunction in von Willebrand Disease Type 2B Platelets"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMarten Hansen (Sanquin Bloodbank, The Netherlands)
"Megakaryopoiesis from Induced Pluripotent Stem Cells: Gray Platelet Syndrome iPS Cell Differentiation Uncovers a Role for Gfi1b in Megakaryopoiesis and Endothelial Specification"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amKellie Machlus (Harvard Medical School, USA)
"Protein Degradation Through the Ubiquitin-Proteasome Pathway Is Necessary for Proplatelet Production"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amMegan Rost (University of Michigan, USA)
"Nfe2 Is Dispensable for Early, but Required for Adult Thrombocyte Formation and Function in Zebrafish"
10:15 am - 10:20 amDiscussion
10:20 am - 11:00 amPanel Discussion
"Careers in Science: Keys to Success"
  • Karin Hoffmeister (Brigham and Women's Hospital / Harvard Medical School, USA)
  • John Kulman (Codiak Biosciences, USA)
  • Jose Lopez (Bloodworks Northwest Research Institute, USA)
  • Alisa Wolberg (University of North Carolina at Chapel Hill, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmHemostasis, Sepsis and Inflammation: Understanding Mechanisms of Disease
Discussion Leaders: Matthew Rondina (University of Utah, USA) and Frederik Denorme (KU Leuven Kulak, Belgium)
1:30 pm - 1:45 pmJulie Goswami (University of Pittsburgh Medical Center, USA)
"Innate Immune Response After Liver Ischemia/Reperfusion Promotes Distal Organ Injury Through Maintenance of a Pro-Coagulant State"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmJessica Morales (University of Puerto Rico, Puerto Rico)
"Emerging Role for TLT-1 in the Interception Between Inflammatory Hemorrhage and Hemostasis"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmJulie Rayes (University of Birmingham, United Kingdom)
"CLEC-2 Deficient Platelets Modulate the Inflammatory Response Following Toxin-Mediated Inflammation in Mice"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL132417-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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