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Biology of Aging (GRS)
Gordon Research Seminar

The Ins and Outs of Aging: Molecular Process to Systems Biology of Aging

Dates

July 8-9, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Isabel Beerman & Mitsukuni Yoshida

Meeting Description

The Gordon Research Seminar on Biology of Aging is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting will be the fundamental processes and pathways of aging emerging from studies of model organisms, how these concepts advance our understanding of human aging and age associated diseases, and how this knowledge can be translated into successful interventions to ameliorate the functional decline of age. The GRS will provide junior scientists a venue to present, discuss and receive feedback on their research, further their knowledge of the established principles as well as relevant pending questions in the field, promote interactions and constructive networking with successful established scientists as well as with their peers, and engage in workshops with role models from academia, industry and government on career development.

Related Meeting

This GRS was held in conjunction with the "Biology of Aging" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Blood as a Tissue to Study and Regulate Aging
Discussion Leader: Mitsukuni Yoshida (Washington University in St. Louis, USA)
3:15 pm - 3:40 pmTony Wyss-Coray (Stanford University School of Medicine, USA)
"Blood as a Tissue to Study and Regulate Aging"
3:40 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmJonathan Lin (Washington University School of Medicine in St. Louis, USA)
"Upregulation of microRNA-150 in Aged Macrophages Promotes Age-Related Macular Degeneration"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmThe "Ins": Cell Intrinsic Changes Associated with Aging
Discussion Leader: Frank Madeo (Karl-Franzens-Universität Graz, Austria)
5:30 pm - 5:40 pmJulia Adelöf (University of Gothenburg / AstraZeneca, Sweden)
"Aging Analysis of Mice Overexpressing the Proteasome Activator PA28αβ"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmMitsukuni Yoshida (Washington University in St. Louis, USA)
"eNAMPT as an Adipose-Derived NAD+ Biosynthetic Enzyme that Systemically Regulates Aging"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmJohanna Heid (University of Frankfurt, Germany)
"Up-Regulation of microRNA-29 Family Protects from Cardiac Hypertrophy and Fibrosis in the Novel Aging Model Nothobranchius furzeri"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pmNelson Hsieh (Case Western Reserve University, USA)
"A Conserved KLF-Autophagy Pathway Modulates Nematode Lifespan and Mammalian Age-Associated Vascular Dysfunction"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmKatja Hoedjes (University of Lausanne, Switzerland)
"The Genomic Basis of Experimental Evolution of Aging in Drosophila: How Individual SNPs Affect Lifespan"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmAlejandra Hernández (European Research Institute for the Biology of Aging, University Medical Center Groningen, The Netherlands)
"Identification of Heterogeneous Senescence-Associated Transcriptional Programs"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmAmiq Gazdhar (University Hospital of Bern, Switzerland)
"Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-CM) in the Bleomycin Injured Rat Lung"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmArne Søraas (Oslo University Hospital, Norway)
"Possible Reversal of Cellular Age in Transplanted Human Haematopoietic Stem Cells"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amKeynote Session: Spermidine, a Natural Autophagy Inducer Against Age-Associated Disease / The "Outs": Cell Extrinsic Changes Associated with Aging
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:25 amFrank Madeo (Karl-Franzens-Universität Graz, Austria)
"Spermidine, a Natural Autophagy Inducer Against Age-Associated Disease"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amElizabeth Stahl (University of Pittsburgh, USA)
"Accumulation of Bone Marrow Derived Macrophages in Aged Murine Livers"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amMichael Stout (University of Oklahoma Health Sciences Center, USA)
"17a-Estradiol Acutely Acts Through Hypothalamic Proopiomelanocortin Expressing Neurons"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amAndrew Rallis (Institute of Biology Valrose, France)
"The Hh Signalling Pathway Modulates Lifespan Determination and Neuroprotection in Drosophila"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amRitchie Ho (Cedars-Sinai Medical Center, USA)
"Mechanistic Insights into Aging and ALS Pathology Using Orthologous Transcriptomic Analysis in Mice"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amMarkus Schosserer (University of Natural Resources and Life Sciences, Vienna, Austria)
"Two Distinct Ribosomal RNA Base Methylations Modulate Healthy Lifespan"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amOliver Hahn (Max Planck Institute for the Biology of Ageing, Germany)
"Age-Related Changes in DNA Methylation Are Retarded by Dietary Restriction and Are Associated with Reprogramming of Lipid Metabolism"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Getting Your Next Position and Funding It
Discussion Leader: Isabel Beerman (National Institutes of Health, USA)
1:30 pm - 1:50 pmMalene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Scientific Career Transitions"
1:50 pm - 1:55 pmDiscussion
1:55 pm - 2:10 pmBita Nakhai (National Institute on Aging, NIH, USA)
"NIH Grant Review Process"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:30 pmPanel Discussion
"Advice for Promoting Career Development"
  • Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
  • Bita Nakhai (National Institute on Aging, NIH, USA)
  • Tony Wyss-Coray (Stanford University School of Medicine, USA)
  • Adam Antebi (Max Planck Institute for Biology of Ageing, Germany)
  • Shin-Ichiro Imai (Washington University in St. Louis School of Medicine, USA)
  • Frank Madeo (Karl-Franzens-Universität Graz, Austria)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible, in part by the National Institute On Aging of the National Institutes of Health under Award Number 1R13 AG056105 - 01. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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