The Gordon Research Seminar on Barriers of the CNS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
The Barriers of the CNS Gordon Research Seminar offers an
excellent opportunity for young scientists to interact and network with peers
and experts in the brain barriers field in an informal environment. The 2016
meeting entitled "Involvement of the CNS barriers in health, drug discovery,
and disease", will focus on new research being conducted on various aspects of
the brain barriers field. While an intact blood-brain barrier is essential to
maintain CNS homeostasis, it also poses an obstacle to the effective delivery
of treatments for neurological diseases. Furthermore, disruption of this
barrier is also a hallmark feature of many disorders with great global importance. Understanding the mechanisms of this
disruption as well as ways to more efficiently deliver drugs to the CNS are
important to rationally design therapeutic interventions to treat these
diseases. The 2016 meeting will address new, cutting-edge research in these areas
and will offer participants the opportunity to engage in lively discussions,
thus advancing everyone's knowledge in the field.
The Seminar will also prepare young scientists to actively
participate in the Gordon Research Conference (Barriers of the CNS: key
interfaces between the nervous system and the rest of the body in health and
disease), which will be held from June 19-24.
This GRS was held in conjunction with the "Barriers of the CNS" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Regulation of Barrier Maintenance and Heterogeneity in the CNS|
|Discussion Leaders: Damir Janigro (Flocel Inc., USA) and Brandon Kim (San Diego State University, USA)|
|3:45 pm - 4:15 pm||Stefan Liebner (University of Frankfurt, Germany)|
"Regulation of Barrier Maintenance and Heterogeneity in the CNS"
|4:15 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||CNS Barriers in Health and Disease|
|Discussion Leaders: Aric Logsdon (West Virginia University, USA) and Steffen Storck (Johannes Gutenberg-University of Mainz, Germany)|
|7:30 pm - 7:50 pm||Regina Faubel (Max-Planck Insitute for Biophysical Chemistry, Germany)|
"Ependymal Cilia Generate a Logistic Network"
|7:50 pm - 8:00 pm||Discussion|
|8:00 pm - 8:20 pm||Aaron Dadas (Flocel Inc., USA)|
"Evidence for or Against Glymphatic Clearance of Phosphorylated Tau in Human Brain"
|8:20 pm - 8:30 pm||Discussion|
|8:30 pm - 8:50 pm||Marijke De Bock (Ghent University, Belgium)|
"Connexin and Calcium Signaling in Glial and Endothelial Cells Are Implicated in Inflammation-Induced Blood-Brain Barrier Permeability Changes In Vivo"
|8:50 pm - 9:00 pm||Discussion|
|9:00 pm - 9:20 pm||Matthew Simon (Oregon Health and Science University, USA)|
"Age-Linked Regulation of Perivascular Localization of the Astrocytic Water Channel Aquaporin-4 (AQP4)"
|9:20 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Delivery to the CNS|
|Discussion Leaders: Irena Loryan (Uppsala University, Sweden) and Jeff Lochhead (University of Wisconsin-Madison, USA)|
|9:00 am - 9:20 am||Aurore Lebrun (Thomas Jefferson University, USA)|
"Non Pathological Delivery of Immune Effectors Across the Blood-Brain Barrier"
|9:20 am - 9:30 am||Discussion|
|9:30 am - 9:50 am||Piotr Siupka (Aarhus University, Denmark)|
"Receptors Trafficking in Brain Endothelial Cells, and Its Implication for Receptor Mediated Transcytosis and Drug Delivery to the Brain"
|9:50 am - 10:00 am||Discussion|
|10:00 am - 10:20 am||Michelle Pizzo (University of Wisconsin-Madison, USA)|
"Investigating the Whole Brain Distribution of Intrathecally Applied Antibodies and Antibody Fragments Using Ex Vivo Fluorescence Microscopy and In Vivo Magnetic Resonance Imaging"
|10:20 am - 10:30 am||Discussion|
|10:30 am - 10:50 am||Dongfen Yuan (University of North Carolina at Chapel Hill, USA)|
"Synthesis, Characterization and Intranasal PK Analysis of N-Terminally Modified Pluronic Leptin for Treatment of Obesity"
|10:50 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Career Panel|
|Discussion Leader: Robert Thorne (University of Wisconsin-Madison, USA)|
|1:30 pm - 2:30 pm||Panel Discussion|
|"Scientific Career Paths"|
- Bjoern Bauer (University of Kentucky, USA)
- Robert Bell (Pfizer, USA)
- Elizabeth De Lange (Leiden University, The Netherlands)
- Britta Engelhardt (University of Bern, Switzerland)
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS098650. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.