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Barriers of the CNS (GRS)
Gordon Research Seminar

Involvement of the CNS Barriers in Health, Drug Discovery, and Disease

Dates

June 18-19, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chairs:
Roosmarijn Vandenbroucke & Holly L. Johnson

Meeting Description

The Gordon Research Seminar on Barriers of the CNS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The Barriers of the CNS Gordon Research Seminar offers an excellent opportunity for young scientists to interact and network with peers and experts in the brain barriers field in an informal environment. The 2016 meeting entitled "Involvement of the CNS barriers in health, drug discovery, and disease", will focus on new research being conducted on various aspects of the brain barriers field. While an intact blood-brain barrier is essential to maintain CNS homeostasis, it also poses an obstacle to the effective delivery of treatments for neurological diseases. Furthermore, disruption of this barrier is also a hallmark feature of many disorders with great global importance. Understanding the mechanisms of this disruption as well as ways to more efficiently deliver drugs to the CNS are important to rationally design therapeutic interventions to treat these diseases. The 2016 meeting will address new, cutting-edge research in these areas and will offer participants the opportunity to engage in lively discussions, thus advancing everyone's knowledge in the field.

The Seminar will also prepare young scientists to actively participate in the Gordon Research Conference (Barriers of the CNS: key interfaces between the nervous system and the rest of the body in health and disease), which will be held from June 19-24.

Related Meeting

This GRS was held in conjunction with the "Barriers of the CNS" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Regulation of Barrier Maintenance and Heterogeneity in the CNS
Discussion Leaders: Damir Janigro (Flocel Inc., USA) and Brandon Kim (San Diego State University, USA)
3:45 pm - 4:15 pmStefan Liebner (University of Frankfurt, Germany)
"Regulation of Barrier Maintenance and Heterogeneity in the CNS"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCNS Barriers in Health and Disease
Discussion Leaders: Aric Logsdon (West Virginia University, USA) and Steffen Storck (Johannes Gutenberg-University of Mainz, Germany)
7:30 pm - 7:50 pmRegina Faubel (Max-Planck Insitute for Biophysical Chemistry, Germany)
"Ependymal Cilia Generate a Logistic Network"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAaron Dadas (Flocel Inc., USA)
"Evidence for or Against Glymphatic Clearance of Phosphorylated Tau in Human Brain"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMarijke De Bock (Ghent University, Belgium)
"Connexin and Calcium Signaling in Glial and Endothelial Cells Are Implicated in Inflammation-Induced Blood-Brain Barrier Permeability Changes In Vivo"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMatthew Simon (Oregon Health and Science University, USA)
"Age-Linked Regulation of Perivascular Localization of the Astrocytic Water Channel Aquaporin-4 (AQP4)"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amDelivery to the CNS
Discussion Leaders: Irena Loryan (Uppsala University, Sweden) and Jeff Lochhead (University of Wisconsin-Madison, USA)
9:00 am - 9:20 amAurore Lebrun (Thomas Jefferson University, USA)
"Non Pathological Delivery of Immune Effectors Across the Blood-Brain Barrier"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPiotr Siupka (Aarhus University, Denmark)
"Receptors Trafficking in Brain Endothelial Cells, and Its Implication for Receptor Mediated Transcytosis and Drug Delivery to the Brain"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMichelle Pizzo (University of Wisconsin-Madison, USA)
"Investigating the Whole Brain Distribution of Intrathecally Applied Antibodies and Antibody Fragments Using Ex Vivo Fluorescence Microscopy and In Vivo Magnetic Resonance Imaging"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amDongfen Yuan (University of North Carolina at Chapel Hill, USA)
"Synthesis, Characterization and Intranasal PK Analysis of N-Terminally Modified Pluronic Leptin for Treatment of Obesity"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Robert Thorne (University of Wisconsin-Madison, USA)
1:30 pm - 2:30 pmPanel Discussion
"Scientific Career Paths"
  • Bjoern Bauer (University of Kentucky, USA)
  • Robert Bell (Pfizer, USA)
  • Elizabeth De Lange (Leiden University, The Netherlands)
  • Britta Engelhardt (University of Bern, Switzerland)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS098650. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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