Gordon Research Conferences
Meeting Details

Plasminogen Activation & Extracellular Proteolysis (GRS)
Gordon Research Seminar

Novel Biological Functions of Plasminogen Activation and Extracellular Proteolysis, from Basic Mechanisms to Translational Science


February 13-14, 2016


Four Points Sheraton / Holiday Inn Express
Ventura, CA


Andre L. Samson & Colin A. Kretz

Meeting Description

The Gordon Research Seminar on Plasminogen Activation and Extracellular Proteolysis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is on the basic and clinical research in the field of pericellular proteolysis in general, and plasminogen activation in particular. The meeting seeks to attract young scientists to present their work on the molecular mechanism of pericellular proteolysis, its function in tissue development, homeostasis, and disease, and on the development of new, protease-related therapies for the treatment of disorders of the cardiovascular and central nervous systems, as well as cancer.

Two invited speakers will address the GRS and set the tone for a truly outstanding meeting:

  • Professor Christopher Overall (The University of British Colombia) will be the keynote speaker for this GRS. Professor Overall is a world leader in the field of extracellular proteolysis.
  • Dr. Angela Colmone will act as the GRS's mentor and offer important career development advice based on her experiences as a successful researcher and senior editor of Science Translational Medicine.

Related Meeting

This GRS was held in conjunction with the "Plasminogen Activation & Extracellular Proteolysis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmExtracellular Proteases in Tissue Remodelling
Discussion Leaders: Stephanie Moore (Vanderbilt University, USA) and Bruno Costa (Universidade Federal de Minas Gerais, Brazil)
3:45 pm - 3:50 pmOpening Remarks
3:50 pm - 4:05 pmCourtney Baker (Vanderbilt University, USA)
"Osteopontin Defiency Contributes to Heterotopic Ossification"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmSumeda Nandadasa (Cleveland Clinic Lerner Research Institute, USA)
"Sculpting the Mammalian Embryo, Role of ADAMTS9-Mediated ECM Proteolysis During Embryogenesis"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExtracellular Proteases in Inflammation and Immunity
Discussion Leaders: Christopher Overall (The University of British Columbia, Canada), Nicholas Mignemi (Vanderbilt University, USA), Eugenia Salcedo (University of California, San Francisco, USA) and Andre Samson (University of Sydney, Australia)
7:30 pm - 7:45 pmJuliana Priscila Vago da Silva (Universidade Federal de Minas Gerais, Brazil)
"Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmCameron Landers (Baylor College of Medicine, USA)
"The Pro-Inflammatory Role of Fibrinogen-TLR4 Signaling"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmDominik Draxler (Monash University, Central Clinical School, Australian Centre for Blood Diseases, Australia)
"Does the Plasminogen Activation System Contribute to Immunosuppression After Traumatic Brain Injury?"
8:25 pm - 8:30 pmDiscussion
Keynote Session
8:30 pm - 9:20 pmChristopher Overall (The University of British Columbia, Canada)
"Systems Biology Deconvolution of the Pervasive Interactions of Proteases and Inhibitors Forming the Protease Web"
9:20 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMentorship Component: Career Development
Discussion Leaders: Colin Kretz (University of Michigan, USA), Agnieszka Jendroszek (Aarhus University, Denmark), Mahsa Fallah (Umea University, Sweden) and Angela Colmone (Science Translational Medicine, USA)
9:00 am - 9:45 amAngela Colmone (Science Translational Medicine, USA)
"Advice and Insights About the Peer-Review Process from the Senior Editor of 'Science Translational Medicine'"
9:45 am - 10:00 amDiscussion
Extracellular Proteases in Haemostasis and Thrombosis
10:00 am - 10:15 amAmelia Tomkins (Heart Research Institute, Australia)
"Thrombolysis for Recanalization in a Model of Carotid Artery Occlusion"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amThomas Bonnard (Australian Center for Blood Diseases, Australia)
"Thrombin Cleavable Micro Plasminogen Coupled to a Blocking Single-Chain Antibody Specific for Activated GPIIb/IIIa: A New Safe Thrombosis Treatment?"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amJathushan Palasubramaniam (Baker IDI Heart and Diabetes Institute, Australia)
"Activated-Platelet Targeted Fibrinolytic Drugs: Novel Targeted-Theranostic Microbubbles for Simultaneous Diagnosis, Treatment and Monitoring"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmExtracellular Proteases in Cancer
Discussion Leaders: Marie Bay (Finsen Laboratory, Rigshospitalet, Denmark) and Fausto Varela (Wayne State University, USA)
1:30 pm - 1:45 pmGregory Conway (University of Maryland School of Medicine, USA)
"The Role of Testisin and PAR-2 in Ovarian Cancer Angiogenic Signaling"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmAndrew Murray (Wayne State University, USA)
"Identifying the Role of TMPRSS13 Protease in Breast Cancer"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmMarta Kubala (Children's Hospital Los Angeles, USA)
"Tumor Derived PAI-1 Recruits Monocytes and Triggers Their Polarization Towards Alternatively Activated M2 Phenotype in an IL-6 - STAT3 Dependent Manner"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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