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Signal Transduction by Engineered Extracellular Matrices (GRS)
Gordon Research Seminar

Intersection of Extracellular Matrix and Clinical Pathology to Inform Tissue Engineering for Development of Molecular and Regenerative Therapies

Dates

June 25-26, 2016

Location

University of New England
Biddeford, ME

Organizers

Chairs:
Christi D. Cook & Chris Madl

Meeting Description

The Gordon Research Seminar on Signal Transduction by Engineered Extracellular Matrices is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this GRS is to explore ways in which engineered matrices guide cellular behaviors, including cell fate and differentiation decisions, cell-matrix or cell-cell signaling events, and emergent behaviors, like morphogenesis, leading to higher order cell and tissue organization, both during development and in pathological disease states. Oral presentations will be selected from abstracts submitted by young investigators (students and post-docs) from disciplines including cell and developmental biology, immunology, chemistry, materials science, applied math, systems biology and bioengineering.

Related Meeting

This GRS was held in conjunction with the "Signal Transduction by Engineered Extracellular Matrices" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmLaying the Foundation: 3D Matrix Patterning of Engineered Extracellular Matrices
Discussion Leaders: Cassady Rupert (Brown University, USA) and Rebecca Scott (University of Delaware, USA)
3:45 pm - 4:00 pmLisa Sawicki (University of Delaware, USA)
"Tunable Hydrogels to Understand the Role of the Microenvironment in Regulating Breast Cancer Dormancy and Recurrence"
4:00 pm - 4:05 pmDiscussion
4:05 pm - 4:20 pmBagrat Grigoryan (Rice University, USA)
"Stereolithography of Engineered Tissues Containing Interpenetrating Vascular Networks"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMolecular Mechanisms of Cell-ECM Signaling: From Matrix Molecules to Mechanics
Discussion Leaders: Victor Hernandez-Gordillo (Massachusetts Institute of Technology, USA) and Sharvari Sathe (National University of Singapore, Singapore)
7:30 pm - 7:50 pmAna Porras (University of Wisconsin-Madison, USA)
"Creation of Glycosaminoglycan-Enriched Environments to Study Aortic Valve Pathobiology"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLauren Jansen (University of Massachusetts Amherst, USA)
"Marrow Tissue Induces Sensitivity to IL-6 and VEGF-A in Mesenchymal Stem Cells During Breast-to-Bone Metastasis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmVincent Fitzpatrick (Laboratoire des Matériaux et du Génie Physique, Grenoble Institute of Technology, France)
"Signal Mingle: Micropatterns of BMP-2 and Fibronectin on Soft Biopolymeric Films Regulate Myoblast Spreading and SMAD Signaling"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLaralynne Przybyla (University of California, San Francisco, USA)
"Matrix Tension Directs Tissue-Level Organization to Prime Embryonic Stem Cells for Mesoderm Differentiation"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amEngineered Microenvironments to Parse Cell-Cell Communication
Discussion Leaders: Evan Chiswick (Massachusetts Institute of Technology, USA) and Alexander Zevin (University of Washington, USA)
9:00 am - 9:20 amJorge Valdez (Massachusetts Institute of Technology, USA)
"Measurement of Local Epithelial-Stromal Communication Enabled by On-Demand Sortase A-Mediated Dissolution of Synthetic, Modular, Extracellular Matrix"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMarina Shumakovich (University of Maryland, USA)
"Microfluidic Models to Understand Tumor Cell Interactions with the Brain Microenvironment at the Blood-Brain Barrier"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDavid Belair (U.S. Environmental Protection Agency, USA)
"Engineered Three-Dimensional Multicellular Culture Model to Recapitulate Morphogenetic Fusion Using Human Cells"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amAlexander Buffone (University of Pennsylvania, USA)
"Migration Against the Direction of Flow Is LFA-1 Dependent in a Human Hematopoietic Stem Cell Line"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leaders: Christi Cook (Massachusetts Institute of Technology, USA) and Chris Madl (Stanford University, USA)
1:30 pm - 2:30 pmPanel Discussion
"Exploring Careers in Academia, Government, and Industry"
  • Shannon Hughes (Division of Cancer Biology, National Cancer Institute, NIH, USA)
  • Shelly Peyton (University of Massachusetts Amherst, USA)
  • Manu Platt (Georgia Institute of Technology, USA)
  • Serena Silver (Novartis Institutes for BioMedical Research, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13 HL95217-01 from the National Institutes of Health, National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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