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Cornea, Biology & Pathobiology of the
Gordon Research Conference

Function of the Ocular Surface and Tear Film in Health and Disease
Note: This conference is currently known as "Cornea & Ocular Surface Biology & Pathology".

Dates

February 28 - March 4, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Darlene A. Dartt & Robert M. Lavker

Vice Chairs:
Shigeto Shimmura & Julie T. Daniels

Meeting Description

The 2016 Gordon Research Conference (GRC) on "Biology and Pathobiology of the Cornea: Function of the Ocular Surface and Tear Film in Health and Disease" will focus on innovative research on the cornea, conjunctiva, tear film, and the glands that produce tears. Researchers and trainees will be brought together to exchange data, educate one another and foster new ideas in a GRC format that will enable cross-disciplinary discussions and the development of collaborations. As a result, this meeting will improve our understanding of cornea, conjunctiva and tear film biology and pathobiology. This enhancement in knowledge will form the foundation for the elaboration of novel therapeutic modalities for diseases resulting in ocular surface inflammation, pain and blindness. Research exploring how tissues set up boundaries and their regulation, which are crucial to maintaining the integrity and homeostasis between the conjunctiva, limbus and cornea, will be presented. Basic aspects of lacrimal gland, meibomian gland and conjunctival cell biology and physiology will be highlighted with translation into dry-eye and other ocular surface inflammatory diseases. Presentations will feature the newest concepts on pain, as well as gender-bias associated with dry eye. Etiology of corneal diseases will be highlighted, as well as novel presentations on how epithelial cell populations migrate to seal wounds, cell populations can be expanded ex vivo and aberrations in the barrier can be repaired. By bringing together investigators outside of the ocular community, such as skin and salivary gland as well as those at the forefront of ocular surface biology, the Conference will provide unique opportunities for cross-fertilization among young investigators with leaders in several fields. Several poster presenters will be selected for short talks. This is an extremely collegial Conference with ample time both in programmed discussions as well as informal afternoon and evening activities for scientists in varied disciplines and specialties to share their passion for research in the anterior surface.

The associated Gordon Research Seminar (GRS) is targeted for graduate students, post-doctoral fellows, early career scientists and junior faculty. As such, it provides a unique forum for these groups to discuss their research in a less intimidating environment. Features of this GRS will be a keynote address that will focus on how to maximize productivity at the bench and ultimately produce consistent high quality data. Poster sessions and short talks derived from submitted abstracts will follow. The GRS will culminate with a presentation on how to critically evaluate the literature followed by an overall discussion and evaluation session.

Related Meeting

This GRC was held in conjunction with the "Cornea, Biology & Pathobiology of the" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Setting Our Sights: Future of Ocular Surface and Tear Film Research
Discussion Leader: Ilene Gipson (Schepens Eye Research Institute, Massachusetts Eye and Ear, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:00 pmIntroduction by Discussion Leader
8:00 pm - 8:30 pmRobert Lavker (Northwestern University, USA)
"From Keratin Filaments to Stem Cell-Maintenance of the Ocular Anterior Segment"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmDimitri Azar (University of Illinois at Chicago College of Medicine, USA)
"Future of Corneal Research"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEstablishment of Tissue Boundaries: Implications for Cornea and Conjunctiva
Discussion Leaders: Sophie Deng (Jules Stein Eye Institute, University of California, Los Angeles, USA) and James Zieske (Schepens Eye Research Institute / Massachusetts Eye and Ear, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amDavid Wilkinson (The Francis Crick Institute, United Kingdom)
"Border Control: Roles and Regulations of Boundary Formation"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSpiro Getsios (Feinberg School of Medicine, Northwestern University, USA)
"Epithelial Tissue Compartment Organization by Eph Receptors and Ephrins"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Koji Kitazawa (Kyoto Prefectural University of Medicine, Japan)
"PAX6-Depleted Corneal Epithelial Cells Using the CRISPER/Cas9 System Exhibited Loss of Corneal Identity"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amSelected from Poster Abstracts: Peter Lwigale (Rice University, USA)
"Novel Functions of CXCL14 in Regulating Neurovascular Patterning During Corneal Development"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amKohji Nishida (Osaka University Medical School, Japan)
"Differentiation and Maintenance of Corneal Epithelial Stem Cells from Human iPS Cells (Introducing Corneal Epithelial Progenitor Cell: iCEP)"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmNick Di Girolamo (University of New South Wales, Australia)
"The Limbus: Border Protector and Generator of Mobile Corneal Epithelia"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Han Peng (Northwestern University, USA)
"Autophagy Is Enhanced in Limbal Epithelial Basal Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMaintenance of Corneal Homeostasis
Discussion Leaders: Mary Ann Stepp (George Washington University School of Medicine and Health Sciences, USA) and Alexander Ljubimov (Cedars-Sinai Medical Center, USA)
7:30 pm - 7:50 pmStephen Sugrue (University of Florida, USA)
"Alternative RNA Processing and the Regulation of Gene Expression in the Corneal Epithelium"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRuby Shalom-Feuerstein (Technion - Israel Institute of Technology, Israel)
"The Origin, Fate, and Regulation of Stem Cells in the Corneal Epithelium"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRichard Carthew (Northwestern University, USA)
"MicroRNAs in Drosophila Eye Development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSue Menko (Thomas Jefferson University, USA)
"The Hijacking of Autophagy Signaling Regulators in Development"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMechanism of Tear Film Formation by the Lacrimal Gland, Meibomian Glands, and Conjunctiva
Discussion Leaders: Alison McDermott (University of Houston, USA) and Driss Zoukhri (Tufts University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amSarah Hamm-Alvarez (University of Southern California School of Medicine, USA)
"From Mice to Men: Insights into Disease Mechanisms from Tear Biomarkers in Sjogren's Syndrome"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSharmila Masli (Boston University School of Medicine, USA)
"Chronic Ocular Surface Inflammation: TSP-1 Mediated Regulation"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Chia-Yang Liu (School of Optometry, Indiana University, USA)
"Canonical Notch 1 Signaling Is Essential for Ocular Surface Gland Development"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amSelected from Poster Abstracts: Nancy Reyes (Duke University School of Medicine, USA)
"Pathogenesis of Meibomian Gland Dysfunction (MGD) Requires the T Cell-Neutrophil Axis in the Allergy Setting"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amJames Jester (University of California, Irvine, USA)
"Meibocyte Differentiation and Renewal: Insights into Novel Mechanisms for Meibomian Gland Disease"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmEdit Tóth-Molnár (University of Szeged, Hungary)
"The Role of Duct Cells in Lacrimal Gland Function: New Experimental Results and Further Research Directions"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Helen Makarenkova (Scripps Research Institute, USA)
"Myoepithelial Cells Help the Lacrimal Gland to Repair Itself"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOcular Surface Pain: Etiology and Treatments
Discussion Leaders: Yolanda Diebold (University of Valladolid, Spain) and Michael Stern (ImmunEyeZ, LLC, USA)
7:30 pm - 7:50 pmDiana Bautista (University California, Berkeley, USA)
"Molecular Mechanisms of Itch, Touch, and Pain"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBlanka Golebiowski (School of Optometry and Vision Science, The University of New South Wales, Australia)
"Ocular Surface Sensitivity, Corneal Nerve Morphology and Ocular Discomfort Symptoms"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDavid Borsook (Boston Children's Hospital, Harvard Medical School, USA)
"Corneal Pain: Neuroscience and Controversies"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJuana Gallar (Universidad Miguel Hernandez, CSIC, Spain)
"Peripheral Pain Mechanisms in Pathological Processes Involving Ocular Inflammation and Nerve Injury"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWhat We Can Learn from Common Diseases of Skin, Salivary Glands and Other Tissues
Discussion Leaders: Esen Akpek (Wilmer Eye Institute, USA) and David Woodley (Keck School of Medicine, University of Southern California, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDavid Woodley (Keck School of Medicine, University of Southern California, USA)
"Concepts in Wound Healing: A Central Role for Hsp90a"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amM. Peter Marinkovitch (Stanford University School of Medicine, USA)
"Pathogenesis and Molecular Therapy of Cutaneous Basement Membrane Disorders: Implications for Corneal Biology"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amSelected from Poster Abstracts: Yi Wei (Icahn School of Medicine at Mount Sinai, USA)
"Role of SKQ1 in Inflammation and Wound Healing Associated with Ocular Surface Disease: Cell Culture Models"
10:15 am - 10:20 amDiscussion
10:20 am - 10:30 amSelected from Poster Abstracts: Gary Hin-Fai Yam (Singapore Eye Research Institute, Singapore)
"Inhibiting Glycogen Synthase Kinase-3 and TGFb Signaling Promoted Mesenchymal-Epithelial Transition of Human Adipose-Derived Stem Cells for Ocular Surface Reconstruction"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amDenise Faustman (Harvard Medical School / Massachusetts General Hospital, USA)
"The BCG Vaccine - Why Sjogren's Syndrome Trials?"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amAmmon Peck (College of Veterinary Medicine, University of Florida, USA)
"Are Immune Responses Tissue-Specific for Lacrimal and Salivary Glands in an Autoimmune Disease Like Sjogren's Syndrome"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Satoru Yoshida (Keio University School of Medicine, Japan)
"iPSC-Derived Neural Crest Cells Accelerate Scarless Wound Healing"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmDiseases of the Ocular Surface (Cornea and Conjunctiva)
Discussion Leaders: Deborah Jacobs (Boston Foundation for Sight, USA) and Mark Rosenblatt (Illinois Eye and Ear Infirmary, University of Illinois at Chicago College of Medicine, USA)
7:30 pm - 7:50 pmFushin Yu (Kresge Eye Institute, Wayne State University, USA)
"Disrupted Balance Between I-1beta and IL-1Ralpha as an Underlying Cause for the Delayed Wound Healing and Nerve Regeneration in the Diabetic Cornea"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmDanielle Robertson (University of Texas Southwestern Medical Center, USA)
"The Impact of Diabetes on the Ocular Surface: Pathogenesis and Prevention"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAli Djalilian (University of Illinois at Chicago, USA)
"Ocular Graft Versus Host Disease: A Pan-Ocular Surface Disease"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOcular Surface Responses to Infection and Inflammation
Discussion Leaders: Shukti Chakravarti (Johns Hopkins University, USA) and Michael Zegans (Section of Ophthalmology, Dartmouth-Hitchcock Medical Center, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMelanie Scott (University of Pittsburgh, USA)
"Inflammasomes in Non-Immune Cells: Not Just a Cytokine Story"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amSuzanne Fleiszig (University of California, Berkeley, USA)
"Corneal Epithelium Versus P. aerugiinosa: The Good, the Bad, and the Ugly"
10:05 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Cintia De Paiva (Baylor College of Medicine, USA)
"Role of Commensal Bacteria in the CD25KO Sjogren's Syndrome Mouse Model"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amSelected from Poster Abstracts: Eric Pearlman (University of California, Irvine, USA)
"Neutrophil P2X7 Receptors Mediate NLRP3 Inflammasome-Dependent IL-1b Secretion and Regulate Streptococcus pneumoniae Keratitis"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amDaniel Saban (Duke University School of Medicine, USA)
"Novel Myeloid Cell Characteristics in Biology/Pathobiology, as Revealed at the Ocular Surface"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmMihaela Gadjeva (Brigham and Women's Hospital, USA)
"Impact of the Microbiota on Ocular Health"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Anthony St. Leger (National Eye Institute, NIH, USA)
"Microbial-Dependent Modulation of Mucosal Immunity at the Ocular Surface"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of Corneal Repair
Discussion Leaders: Natalie Afshari (University of California, San Diego, USA) and Vickery Trinkaus-Randall (Boston University School of Medicine, USA)
7:30 pm - 7:50 pmSangbum Park (Yale University, USA)
"Understanding the Cellular Mechanisms of Epithelial Repair by Live Imaging"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmBruce Ksander (Schepens Eye Research Institute, Harvard Medical School, USA)
"The Function of ABCB5 Gene in Corneal Epithelial Homeostasis and Wound Repair"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKarsten Gronert (University of California, Berkeley, USA)
"Sex Specific Regulation of Tissue PMN and Lipid Mediator Circuits Controls T Cell Responses in the Eye"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDavid Kaplan (Tufts University, USA)
"Tissue Engineering Strategies for Corneal Study and Replacement"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13 EY026341-01 from the National Eye Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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