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Transglutaminases in Human Disease Processes
Gordon Research Conference

Understanding the Varied Pathological Roles of a Multifunctional Enzyme Family

Dates

July 10-15, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Timothy Johnson

Vice Chair:
Mari T. Kaartinen

Meeting Description

Transglutaminases are a large family of structurally and functionally related proteins widely distributed in all living organisms. The predominant and classical function of these enzymes is as protein cross linkers, however as more is discovered about their biology additional roles ranging from non-enzymatic cell adhesion to GTPase activity complicate our understanding of their function in human biology.

There is a rapidly expanding literature describing dysregulation of these enzymes in multiple diseases and how this contributes to the pathogenesis of human diseases. Tissue fibrosis, cancer and metastasis, celiac disease, neurodegenerative disorders such as Parkinson's disease, and skin diseases are just a few examples of where Transglutaminases have been implicated. The 4th Gordon Research Conference on "Transglutaminases in Human Disease Processes" will delve into many disease areas to try and establish where Transglutaminases are central to the disease process so we can better understand the interaction of function with the pathogenic roles being ascribed. Further the conference will address ways to restore normal enzyme function and explore the tools available to help us monitor enzyme levels and function as some approaches approach the clinic.

The meeting will discuss the latest cutting-edge research in the Transglutaminase biology, bringing together the most eminent researchers in Transglutaminase biology from across the world with disease experts. This conference aims to blend the expertise of seasoned scientists with young enthusiastic new comers to the field.

Each session will be aimed at a particular disease area with the discussion lead tasked with building a focused and themed program to maximize participation and output. The sessions will include:

  • Modulators, Structures and Substrates of Transglutaminases
  • The Function of Transglutaminases in Cardiovascular Disease
  • Transglutaminases in Tissue Remodelling, Fibrosis and Scarring
  • Do Transglutaminases Play a Role in Immunology and Rheumatology disorders?
  • What Role do Transglutaminases Play in Neurological disease?
  • Celiac Disease, Gastroenterology and Transglutaminases
  • Transglutaminases in Oncology
  • The Contribution of Transglutaminases to Connective Tissue Disorders

Each presentation within the session will have ample time for in depth discussion. There will also be 4 poster sessions providing a great opportunity for Post-Docs and graduate students to present their work under an informal relaxed atmosphere that fosters networking and idea sharing. For the first time there will be an additional session for the best abstracts from young investigators to be presented as short talks.

The 2016 Gordon Research Conference will bring together the world's leading researchers in the Transglutaminase field at PGA Catalunya Business and Convention Centre in Girona, Spain. This is a fantastic site located within the Catalunya golf course which is regarded as one of the best and most beautiful in Spain. Situated within easy reach of the beautiful beaches of the Costa Brava this is just 5km from Girona airport. The convention centre provides an excellent setting for formal lectures and informal out-of-session discussions, with excellent accommodation, dinning and recreational options.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Transglutaminases: Multifaceted Enzymes with Multiple Roles in Disease Processes
Discussion Leader: Timothy Johnson (UCB, United Kingdom)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:15 pmMauro Piacentini (University of Rome Tor Vergata, Italy)
"The Many Faces of Transglutaminases in Disease Processes"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmKapil Mehta (University of Texas, USA)
"Potential Therapeutic Approaches to Manipulating Transglutaminases in Disease Processes"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmBenjamin Drukarch (VU University Medical Center, The Netherlands)
"PET Imaging and Its Possible Application in Assessing TG2 Activity"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmModulators, Structures and Substrates of Transglutaminases
Discussion Leader: Jeffrey Keillor (University of Ottawa, Canada)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amChristopher Clouthier (University of Ottawa, Canada)
"A Parallel Assessment of TG Conformation and Activity by CE Mass Spec Ion Mobility"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amLaszlo Fesus (University of Debrecen, Hungary)
"Comparative and Population Genomics Data Reveal Strong Evolutionary Pressure on Structure and Functions of Transglutaminase 2"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:15 amBrad Palanski (Stanford University, USA)
"Activation of Extracellular TG2"
11:15 am - 11:20 amDiscussion
11:20 am - 11:45 amMuriel Maurer (University of Louisville, USA)
"Mass Spectrometry and NMR Approaches for Measuring the Specificity of FXIII Towards Its Substrates"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmCandace Kerr (University of Maryland, USA)
"The Inhibition of Transglutaminase Activity in Cancer Stem Cells: Relationship to Conformational Changes and GTP Binding"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Mari Kaartinen (McGill University, Canada)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Function of Transglutaminases in Cardiovascular Disease
Discussion Leader: Dan Berkowitz (Johns Hopkins University, USA)
6:00 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 6:45 pmKelly Beazley (University of Maryland, USA)
"New Approaches to Arterial Calcification Through TG2 and Beta-Catenin"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmErik Bakker (Academic Medical Center, The Netherlands)
"TG2 and Vascular Mechanotransduction"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmLakshmi Santhanam (Johns Hopkins School of Medicine, USA)
"TG2: Separating the Cross Linking-Dependent and Independent Activities in Vascular Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTransglutaminases in Tissue Remodeling, Fibrosis and Scarring
Discussion Leader: Patricia Sime (University of Rochester Medical Center, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amMartin Griffin (Aston University, United Kingdom)
"A New Strategic Approach to the Treatment of Cardiac Fibrosis (CF) Based on Small-Molecule Inhibitors of TG2"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amElisabetta Verderio (Nottingham Trent University, United Kingdom)
"Is Targeting the Transglutaminase-2-Syndecan 4 Interaction a Viable Anti-Fibrotic Strategy?"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amKrishna Penumatsa (Tufts Medical Center, USA)
"TG2 and Pulmonary Hypertension"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amTimothy Johnson (UCB, United Kingdom)
"Application of TG2 Inhibitory Antibodies in Treating Kidney Fibrosis: A Translational Perspective"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Nicole McNeil (University of Ottawa, Canada)
"Novel Irreversible Inhibitors of Human Tissue Transglutaminase"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Thomas Thatcher (University of Rochester, USA)
"Contrasting Pro- and Anti-Fibrotic Roles for Tissue Transglutaminase (TG2) in Lung Fibroblasts and Epithelial Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmDo Transglutaminases Play a Role in Immunology and Rheumatology?
Discussion Leader: Riccardo Ientile (University of Messina, Italy)
6:00 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 6:45 pmZsuzsa Szondy (University of Debrecen, Hungary)
"Loss of Transglutaminase 2 Sensitizes for the Development of Various Chronic Inflammatory Diseases"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmDaniela Caccamo (University of Messina, Italy)
"Different Transglutaminase Isoforms in Cell Response to Inflammatory Stimuli"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmPatrick Schloss (Central Institute of Mental Health, Mannheim, Heidelberg University, Germany)
"Serotonin – More than a Neurotransmitter – TGase-Mediated Serotonylation in Blood and Brain"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWhat Role Do Transglutaminases Play in Neurological Disease?
Discussion Leader: Anne-Marie Van Dam (VU University Medical Center, The Netherlands)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amScott Brady (University of Illinois at Chicago, USA)
"Transglutaminase and Neuronal Functioning"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amM. Maral Mouradian (Robert Wood Johnson Medical School, Rutgers University, USA)
"Transglutaminase 2 in Parkinson's Disease"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:15 amMicha Wilhelmus (VU University Medical Center, The Netherlands)
"Transglutaminase 2 in Alzheimer's Diseasse"
11:15 am - 11:20 amDiscussion
11:20 am - 11:45 amDaniel Aeschlimann (Cardiff University, United Kingdom)
"Transglutaminase 6 in Relation to Neurological Dysfunction"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmSelected from Poster Abstracts: Navina Chrobok (VU University Medical Center Amsterdam, The Netherlands)
"Can Effects of Tissue Transglutaminase Inhibition on the Outcome of a Mouse Model for Multiple Sclerosis Be Attributed to Extracellular TG2?"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Christian Recktenwald (University of Gothenburg, Sweden)
"Tissue Transglutaminase but Not Epidermal Transglutaminase Is Required for the Formation of a Bacteria-Impenetrable Mucus Layer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCeliac Disease, Gastroenterology and Transglutaminases
Discussion Leader: Katri Lindfors (University of Tampere, Finland)
6:00 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 6:45 pmLudvig Sollid (University of Oslo, Norway)
"TG2 Autoantibody Response in Celiac Disease"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmAaron Lerner (Technion - Israel Institute of Technology, Israel / Aesku.Kipp Institute, Germany)
"Microbial Transglutaminase Is a New Bio-Marker and a Potential Inducer of Celiac Disease"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmRenato Monteiro (Center for Research on Inflammation, Université Paris Diderot, France)
"Transglutaminase 2 and Gluten: Essential Pivots in the Pathogenesis of IgA Nephropathy"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTransglutaminases in Oncology
Discussion Leader: Daniela Matei (Northwestern University, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amRichard Eckert (University of Maryland School of Medicine, USA)
"Transglutaminases in Skin Cancer Stem Cells"
9:45 am - 9:55 amDiscussion
9:55 am - 10:20 amWenguo Jiang (Cardiff University School of Medicine, United Kingdom)
"TG4 and Prostate Cancer"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:15 amSalvatore Condello (Northwestern University, USA)
"TG2-FN-Integrin Complex in Ovarian Cancer Stem Cells"
11:15 am - 11:20 amDiscussion
11:20 am - 11:45 amFederica Rossin (University of Rome Tor Vergata, Italy)
"How Does TG2 Participate in Bioenergetic Metabolism"
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmSelected from Poster Abstracts: Uwe Ackermann (Austin Health, Australia)
"Imaging of TG2 Activity in Breast Cancer Using Radiolabelled Hitomi Peptides"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Magdalena Adamczyk (Cardiff University, United Kingdom)
"The Emerging Role of TG2 During Early Osteoarthritis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Contribution of Transglutaminases to Connective Tissue Disorders
Discussion Leader: Mari Kaartinen (McGill University, Canada)
6:00 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 6:45 pmMatthew Flick (Cincinnati Children's Hospital Medical Center, USA)
"FXIII-A and Arthritis and Bone Erosion"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:15 pmHuifang Sun (Faculty of Dentistry, McGill University, Canada)
"Transglutaminases, Bone Resorption and Osteoclastogenesis"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmMartine Charbonneau (Université de Sherbrooke, Canada)
"TG2, Invadopodia and Cartilage Breakdown"
7:50 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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