Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Towards Understanding and Modulating Transglutaminases in Human Diseases
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Evolution and Genomics of Transglutaminases"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Towards Understanding and Modulating Transglutaminases in Human Diseases"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modulators and Medicinal Chemistry of Transglutaminases
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Discovery of ZED1227: A Direct Inhibitor of TG2"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Activity-Based Probes for Tumour-Associated Transglutaminase 2: From Potent and Selective Inhibitors to Radiotracers"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Inhibition and Conformational Modulation of TG2"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"TG2 Inhibition with GK921 Reverses Mesenchymal Transdifferentiation and Radio-Resistance of Glioma Stem Cells"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Allosteric Inhibition Site of Transglutaminase 2 Is Unveiled"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transglutaminases in Neurological Diseases
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Deletion of TG2 from Astrocytes Improves Outcomes After Central Nervous System Injury"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Changes in Glial Cell Functions by TGs in Neurological Diseases"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Beyond TG2 in Neurodegeneration - TG6 Loss and Gain of Function in Spinocerebellar Ataxia 35"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Absence of TG2 Delays Amyloid-Beta Deposition in Alzheimer's Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Activation and Substrates of Transglutaminases
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"ADAM17 as a Promoter of Transglutaminase Activity During Skin Barrier Formation"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Mutations in PADI3, TG3 and Its Substrate Trichohyalin Cause Uncombable Hair Syndrome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Isozyme-Specific Global Identification and Analysis of Transglutaminase Substrates in Fibrotic Diseases"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"TG Regulates Transcriptional Activity by Incorporating Polyamines into the NF-κB-Like Transcription Factor Relish in Drosophila "
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A Novel Fluorescence Anisotropy-Based Assay to Investigate the GTP-Binding Site of Human TG2"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transglutaminases in Inflammatory Diseases and Cellular Stress
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"Inflammation, TG2 and Hypertensive Disorders"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Monocyte- and Macrophage-Derived TG2: A Beneficial or Detrimental Role in Multiple Sclerosis?"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"TG2 Regulates NFκB-Pathway and Subsequent Cytokine Storm in Acute Promyelocytic Leukemia"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"TG2 Controls Mutated CFTR Trafficking by Modulating HSP70 Expression Through Post-Translational Modification of HSF1"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transglutaminases in Hemostasis and Cardiovascular Diseases
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Fibrin(ogen), Factor XIII-A, and Red Blood Cells in Venous Thrombosis"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Search for Cellular Source of Circulating FXIII-A Using Conditional Knockout Mice"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Factor XIII-A, Fibrin Clot Architecture and Tissue Repair in the Cardiovascular System"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"The Role of TG2 in the Infarcted and Failing Heart"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
" Effect of Transglutaminase Conformational Modulation on Vascular Tone "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transglutaminases in Tissue Remodeling, Fibrosis and Scarring
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"TG2 in Lung Fibrosis: Targeting and Twisting!"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Proteomic Profiling Reveals the TG2 Externalization Pathway in Experimental Model of Kidney Fibrosis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"Factor XIII-A in Corneal Keratocytes and Its Possible Role in Corneal Matrix Stabilization and Wound Healing"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Identification of Transglutaminase Cross-Linking Sites in Collagen"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Transglutaminases in Cancer and Energy Metabolism
9:00 am - 9:20 am
Introduction by Discussion Leader
9:20 am - 9:45 am
"Roles of TG2-IL6-Autophagy Regulatory Network in Cancer Survival and Chemoresistance"
9:45 am - 9:55 am
Discussion
9:55 am - 10:20 am
"The Role of TG2 in Tumor Formation in the Peritoneal Environment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Transglutaminase Type 2 Regulation of Proteostasis and Its Implications in Metabolic Reprogramming Under Cellular Stressful Conditions"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Loss of TG2 Sensitizes for the Development of Inflammation, Insulin Resistance and Hepatosteatosis in Mice Kept on High Fat Diet"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Analysis of Differential Expression of TG2 Variants During Treatment with Retinoic Acid Highlights a New 3'-Terminal Transcript and Putatively Involved Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Transglutaminases in Gluten-Related Disorders
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:35 pm
"TG6 Antibodies in Gluten Sensitivity-Related Neurological Dysfunction"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Celiac Anti-TG2 Autoimmunity Explored in an Immunoglobulin Knock-in Mouse"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Antibodies Against Neo-Epitope of Microbial and Human Transglutaminases in Celiac Disease"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
"The Future of Transglutaminase Research"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure