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Transglutaminases in Human Disease Processes
Gordon Research Conference

Towards Understanding and Modulating Transglutaminases in Human Diseases

Dates

June 17-22, 2018

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland Site Information

Organizers

Chair:
Mari T. Kaartinen

Vice Chair:
Jeffrey Keillor

Application Deadline

Applications for this meeting must be submitted by May 20, 2018. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Transglutaminases are a family of structurally and functionally related enzymes that are widely distributed in all living organisms. The predominant and classical function of these enzymes is calcium-dependent protein crosslinking which mostly occurs in the extracellular space. However, novel, non-crosslinking roles ranging from intracellular cell signaling to cell adhesion and transcription have emerged and added a level of challenge to understand of their function in human biology. Recent advances in medicinal chemistry have introduced excellent methods and tools to the field that aid the quest of deciphering the biological roles of transglutaminases in health and disease.

Dysregulation of transglutaminases in multiple human diseases is known and we are beginning to understand how this contributes to the pathogenesis of certain diseases. This 5th Gordon Research Conference on "Transglutaminases in Human Disease Processes" will delve into many disease areas, to establish where transglutaminases are central to the disease process. The conference will address ways to restore normal enzyme function and explore the tools available and needed to help us monitor or modulate enzyme levels, expression or activity.

The meeting will discuss the latest cutting-edge research in transglutaminase chemistry and biology, bringing together the most eminent and innovative researchers, young investigators, trainees and newcomers to this field from across the world. We cordially invite everyone interested in transglutaminases to join the conference.

Each presentation within the session will have ample time for in depth discussion and all sessions will include a presentation chosen from the submitted abstracts. There will also be four poster sessions that will provide a great opportunity for researchers, post-doctoral fellows and graduate students to present their work under an informal and relaxed atmosphere that fosters networking and idea sharing.

Related Meeting

This GRC will be held in conjunction with the "Transglutaminases in Human Disease Processes" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
Nature Publishing Group - Cell Death & Differentiation

Session Titles

The Conference will consist of nine sessions, on the topics listed below. The Conference Chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by November 15, 2017. Please check back for updates.

  • Keynote Session: Towards Understanding and Modulating Transglutaminases in Human Diseases
  • Modulators and Medicinal Chemistry of Transglutaminases
  • Transglutaminases in Tissue Remodeling, Fibrosis and Scarring
  • Activation, Regulation and Substrates of Transglutaminases
  • Transglutaminases in Neurological Diseases
  • Transglutaminases in Hemostasis and Cardiovascular Diseases
  • Transglutaminases in Inflammatory Diseases
  • Transglutaminases in Cancer
  • Transglutaminases in Celiac Disease
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