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Elastin, Elastic Fibers and Microfibrils (GRS)
Gordon Research Seminar

Elastic Tissues and Extracellular Regulation of Growth Factor Signaling

Dates

July 29-30, 2017

Location

University of New England
Biddeford, ME

Organizers

Chairs:
Giselle C. Yeo & Marie Billaud

Meeting Description

The Gordon Research Seminar on Elastin, Elastic Fibers and Microfibrils is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting brings together young scientists at the forefront of elastic fiber-related research to exchange ideas with peers and established scientific leaders. Topics to be covered encompass the latest advances in elastic fiber and microfibril-related research, including the biology of elastic tissues, molecular characterization of elastogenic components, matrix regulation of cell signaling, advances in analytical tools for elastic systems, mechanisms of elastic fiber diseases, and translational applications for tissue repair and regeneration. There is a strong focus on scientific discussion, networking, mentorship, and career development.

Related Meeting

This GRS was held in conjunction with the "Elastin, Elastic Fibers and Microfibrils" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Historical and Current Perspectives on Elastic Fiber Function: From Structure to Signaling
Discussion Leaders: Ewa Mularczyk (University of Manchester, United Kingdom) and Rongmo Zhang (McGill University, Canada)
3:45 pm - 4:15 pmFrancesco Ramirez (Icahn School of Medicine at Mount Sinai, USA)
"Historical and Current Perspectives on Elastic Fiber Function: From Structure to Signaling"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStructure, Composition and Interactions of Elastic Fiber Components
Discussion Leaders: Willeke Daamen (Radboud University Nijmegen Medical Centre, The Netherlands) and Alexander Eckersley (University of Manchester, United Kingdom)
7:30 pm - 7:45 pmJhonsen Djajamuliadi (University of Hawaii at Manoa, USA)
"Investigations of the Unique Role of Alanines in the 'Elastin Puzzle' by Solid-State NMR Spectroscopy and MD Simulations"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmPearl Lee (The University of Sydney, Australia)
"A Cell Adhesive Peptide from Tropoelastin Promotes Sequential Cell Attachment and Spreading via Distinct Receptors"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJingjie Yeo (Massachusetts Institute of Technology, USA)
"Molecular Origins of the Concentration-Dependent Thermal Response in Silk-Elastin-Like Protein Hydrogels: Integrating Experiments and Multiscale Computational Modeling"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMukti Singh (University of Manchester, United Kingdom)
"Structure and Interactions of Elastic Fiber Proteins ADAMTS-L2 and ADAMTS-L4"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJulia Lopez-Guimet (University of Barcelona, Spain)
"Novel Morphological Approaches to Analyse Elastic Laminae Damage in Murine Marfan Syndrome Aortae"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmChelsea Stowell (University of Pittsburgh, USA)
"Pilot Evaluation of an In Situ Tissue Engineered Vascular Graft in the Ovine Arterial Circulation"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amBiology of Elastic Fibers and Microfibrils: Implications in Diseases and Therapeutic Potential
Discussion Leaders: Andriy Cherkas (Lviv National Medical University, Ukraine) and Hana Hakami (McGill University, Canada)
9:00 am - 9:15 amMuthu lakshmi Muthu (McGill University, Canada)
"Therapeutic Potential of Osteoclast Inhibitory Fibrillin-1 Fragments"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amShataakshi Dahal (Lerner Research Institute, Cleveland Clinic, USA)
"Demonstrating Superior Elastin Regenerative Properties of BM-MSC-Derived Smooth Muscle Cells in a 3D Collagenous Milieu"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amMiguel A. Ortega (University of Alcala, Spain)
"Chronic Venous Insufficiency in Pregnancy: Its Relation to Remodeling of Placental Villi"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amKatrin Hildebrandt (University of Cologne, Germany)
"Microenvironmental Regulation of Muscle Homeostasis by Supramolecular Collagen VI and Fibrillin-2 Networks"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amAneesh Ramaswamy (University of Pittsburgh, USA)
"Improved Aortic Elastogenesis Driven by Adipose-Derived Mesenchymal Stem Cell Secreted Factors"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amKai Li Tan (Baylor College of Medicine, USA)
"Ari-1 and Parkin Affect Nuclear Organization, and ARIH1 Variants Are Associated with Aortic Aneurysm"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: I Got My PhD - Now What?
Discussion Leaders: Heena Kumra (McGill University, Canada) and Michael Lockhart (University of Manchester, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"I Got my PhD - Now What?"
  • Julie Phillippi (University of Pittsburgh, USA)
  • Katja Schenke-Layland (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany)
  • Silvia Smaldone (Regeneron Pharmaceuticals, Inc., USA)
  • Anthony Weiss (The University of Sydney, Australia)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by (1R13AR070738-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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