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Fibronectin, Integrins & Related Molecules (GRS)
Gordon Research Seminar

Extracellular Matrix Dynamics and Cell Fate

Dates

January 28-29, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Christine-Maria Horejs

Meeting Description

The Gordon Research Seminar on Fibronectin, Integrins and Related Molecules is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This GRS is a platform for junior scientists to present and discuss their research on the roles, mechanisms, and dynamics of cell-matrix interactions in development, homeostasis, and disease. The seminar encompasses a range of topics from the single molecule level to animal models, including cell migration, cell adhesion, cell phenotype changes, and a variety of methodologies.

Related Meeting

This GRS was held in conjunction with the "Fibronectin, Integrins & Related Molecules" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmMatrix Adhesion and Cancer Invasion
Discussion Leader: Johanna Ivaska (University of Turku, Finland)
3:45 pm - 4:05 pmTobias Zech (University of Liverpool, United Kingdom)
"Matrix Adhesion Site Composition Regulates Nuclear-Force-Coupling to Drive Polarised Cell Migration"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmSarah Palmer (Cancer Research UK Beatson Institute, United Kingdom)
"A Proteomic Approach to Identify Endosomal Cargoes Controlling Cancer Invasiveness"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Migration - Dissecting the Key Players
Discussion Leader: Roy Zent (Vanderbilt University Medical Center, USA)
7:30 pm - 7:45 pmNisha Mohd Rafiq (Mechanobiology Institute, Singapore)
"Myosin II-Dependent Suppression of Podosomes by an ARNO-ARF1 Signaling Axis"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmGregory Goreczny (SUNY Upstate Medical University, USA)
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJennifer Allen (University of Manchester, United Kingdom)
"Integrin-Driven Invasion in Ovarian Cancer"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmLouisiane Perrin (Temple University, USA)
"Role of Soluble Cues in Extracellular Matrix Degradation During Cancer Metastasis"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMary-Kate Hayward (Barts Cancer Institute, Queen Mary University of London, United Kingdom)
"Functional Significance of Integrin avb6 and Fibronectin in DCIS-Myoepithelial Cells: Role in Progression to Invasion"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmNicolas Rabas (Cancer Research UK Beatson Institute, United Kingdom)
"Glutaminolysis: A New Pro-Invasive Role"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amECM Dynamics and Cell Phenotype
Discussion Leader: Charles Streuli (University of Manchester, United Kingdom)
9:00 am - 9:15 amMaqsood Ahmed (University of Edinburgh, United Kingdom)
"Extracellular Matrix in the Developing Ventral Midbrain"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAmanda Haage (University of British Columbia, Canada)
"Modulation of Integrin-Based Cell-Matrix Adhesion via Talin Autoinhibition Regulates Cell Behavior and Migration In Vivo"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amAmbika Kurbet (Institute for Stem Cell Biology and Regenerative Medicine, India)
"Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amNatasha Boel (Rhodes University, South Africa)
"Investigating the Mechanism of Fibronectin Turnover: Identifying a Role for LRP1 and Hsp90"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSophie Smolders (Hasselt University, Belgium)
"Age-Specific Function of Alpha5Beta1 Integrin in Microglial Migration During Early Colonization of the Developing Mouse Cortex"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amDavid Novo (Cancer Research UK Beatson Institute, United Kingdom)
"Microvesicle-Mediated Mutant p53 Gain-of-Function in Cancer and Stromal Cells"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmKeynote Session: Plasticity of Cell-Matrix Interactions
Discussion Leader: Christine-Maria Horejs (Karolinska Institutet, Sweden)
1:30 pm - 2:10 pmPeter Friedl (Radboud University Medical Center, The Netherlands)
"Plasticity of Cell-Matrix Interactions: Lessons from Solving Controversy"
2:10 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible by 1R13AR071167-01 the National Institutes of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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