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Cancer Nanotechnology
Gordon Research Conference

Multimodal Nano-Therapies Against Cancer

Dates

June 18-23, 2017

Location

Mount Snow
West Dover, VT

Organizers

Chair:
Alexander V. Kabanov

Vice Chair:
Ronit Satchi-Fainaro

Meeting Description

The 2017 Cancer Nanotechnology Gordon Research Conference (GRC) provides a unique forum where scientists at every stage of their career can share unpublished, innovative cancer research made possible by the use of nanotechnology. Held biennially since 2011, the 2017 Cancer Nanotechnology GRC is shaping up to be one of the most exciting and important meetings in the field. For the fist time in the history of the Cancer Nanotechnology GRC a student-led Gordon Research Seminar (GRS) will also be held over the weekend preceding the 2017 Cancer Nanotechnology GRC on June 17-18, 2017 at the same location. Nanotechnology is a burgeoning field of study in science and engineering. Its application for cancer diagnosis, imaging, therapy, and prognosis has been a focal point of attention in biomedicine. Most nanomedicine studies are concentrated in cancer. Due to the presence of leaky vasculature and defective lymphatic drainage in solid tumors, nanoparticles selectively accumulate in the tumor via the mechanism of the enhanced permeability and retention (EPR) effect. Thus, nanoparticles are uniquely suitable for delivering diagnostic and/or imaging agents, chemo and gene drugs, and agents to enhance the activity of immunotherapy to the tumor. Nanoparticles also offer an amplification mechanism for bioanalytical detection and sensor devices for cancer markers. It is not surprising that the number of publications in cancer nanotechnology had increased rapidly to about 500-600 per year. The conference will bring together a lively group of exceptional scientists in order to: 1) share cutting-edge research in cancer nanotechnology by experts representing the whole spectrum of life sciences; 2) foster discussion, exchange of ideas, and promote collaborations and 3) enhance the training and development of young scientists and promote diversity. A high priority of the Cancer Nanotechnology GRC and GRS is to increase the diversity of participants. Towards this goal, funds are requested for travel and registration support of female and under-represented speakers.

Related Meeting

This GRC was held in conjunction with the "Cancer Nanotechnology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: RNA Delivery and Therapeutics
Discussion Leader: Alexander Kabanov (University of North Carolina at Chapel Hill, USA)
7:40 pm - 8:20 pmChad Mirkin (Northwestern University, USA)
"Spherical Nucleic Acids for Cancer Immunotherapy and Gene Regulation"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmDaniel Anderson (Massachusetts Institute of Technology, USA)
"Nano-Delivery of Nucleic Acids and Genome Editing Tools"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAttacking Tumor Microenvironment
Discussion Leader: Maria Vicent (Centro de Investigacion Principe Felipe, Spain)
9:00 am - 9:40 amLeaf Huang (University of North Carolina at Chapel Hill, USA)
"Targeting Tumor Associated Fibroblasts for Therapy"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amSangeeta Bhatia (Massachusetts Institute of Technology, USA)
"Activity-Based Nano Sensors of the Tumor Microenvironment"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmMaria Jose Alonso (University of Santiago de Compostela, Spain)
"Multifunctional Nanocapsules for Chimio- and Immunotherapy"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEarly Diagnosis, Imaging and Treatment
Discussion Leader: Shawn Chen (National Institute of Biomedical Imaging and Bioengineering, NIH, USA)
7:30 pm - 8:10 pmRachela Popovtzer (Bar-Ilan University, Israel)
"Nanoparticles for In-Vivo Cell Tracking: Imaging, Detection and Stratified Medicine"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmShan Wang (Stanford University, USA)
"Nanotechnology for Probing Cancer Pathways, Detecting Cancer Early, and Treating Cancer More Effectively"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmCancer Vaccines and Immunoengineering
Discussion Leader: Darrell Irvine (Massachusetts Institute of Technology, USA)
9:00 am - 9:40 amLiangfang Zhang (University of California, San Diego, USA)
"Biomimetic Nanoparticles for Anticancer Vaccination"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amMichael Goldberg (Dana-Farber Cancer Institute, USA)
"Leveraging Nanotechnology to Improve Cancer Immunotherapy"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmMelody Swartz (University of Chicago, USA)
"Nanomaterials Targeting Lymphatic Vessels for Cancer Immunotherapy"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNatural Nanomaterials and Cell-Based Therapies
Discussion Leader: Leaf Huang (University of North Carolina at Chapel Hill, USA)
7:30 pm - 8:10 pmEnnio Tasciotti (Houston Methodist Hospital, USA)
"Biomimetic Engineering of Materials to Tune Immune Response and Inflammation"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmMolly Shoichet (University of Toronto, Canada)
"Hyaluronan-Based Hydrogels Enable 3D Cell Culture and Biomimetic Drug Screening"
9:10 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTargeted, Responsive and Remotely Controlled Nanomedicines
Discussion Leader: Tatiana Bronich (University of Nebraska Medical Center, USA)
9:00 am - 9:40 amKazunori Kataoka (iCONM - Kawasaki Institute of Industrial Promotion, Japan)
"New Paradigm in Nanosystems Penetration into Cancer Crossing Vascular and Stromal Barriers"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amOmid Farokhzad (Brigham and Women's Hospital / Harvard University, USA)
"Targeted Polymeric Nanoparticles: From Discovery to Clinical Trials and Lessons Learned"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmAlberto Gabizon (Shaare Zedek Medical Center / Hebrew University of Jerusalem, Israel)
"Strategies for Development of Liposome-Based Nanomedicines - From Bench to Bedside"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNanoinformatics, Rational Design, Modeling and Simulation
Discussion Leader: Alexander Tropsha (University of North Carolina at Chapel Hill, USA)
7:30 pm - 8:10 pmVittorio Cristini (University of Texas Health Science Center at Houston, USA)
"Mechanistic Patient-Specific Predictive Correlation of Tumor Drug Response with Microenvironment and Perfusion Measurements"
8:10 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmFred Prior (University of Arkansas for Medical Sciences, USA)
"Informatics to Enhance Rigor and Transparency in Nanomedicine Research"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPre-Clinical and Clinical Experience and Lessons Learned
Discussion Leaders: Rogerio Gaspar (University of Lisbon, Portugal) and Puja Sapra (Pfizer, USA)
9:00 am - 9:40 amKazuhiro Takahashi (NanoCarrier Co., Ltd., Japan)
"Clinical Development Strategy of Micellar Nanoparticles in NanoCarrier"
9:40 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:10 amMichelle Bradbury (Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, USA)
"Image-Directed Surgical Treatment of Cancer Using Ultrasmall Silica Nanoparticles: Design, Evaluation and Translation from Lab to Clinic"
11:10 am - 11:30 amDiscussion
11:30 am - 12:10 pmLawrence Mayer (Jazz Pharmaceuticals, Canada)
"Paving a Novel Approach to Developing Anticancer Combinations Through Tumor-Targeting Nanomedicines"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSelected Poster Presentations
8 posters will be selected by the GRC vice chair for 10 minute oral presentations, followed by 5 minutes of discussion.
Discussion Leader: Ronit Satchi-Fainaro (Sackler Faculty of Medicine, Tel Aviv University, Israel)
7:30 pm - 7:40 pmDaniel Heller (Memorial Sloan Kettering Cancer Center, USA)
"Targeted Delivery to Tumor Vasculature Modulates Kinase Inhibitor Pharmacodynamics"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmElena Batrakova (University of North Carolina at Chapel Hill, USA)
"Engineering Exosomes for Targeted Paclitaxel Delivery to Pulmonary Metastases: In Vitro and In Vivo Evaluations"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAssaf Zinger (Technion - Israel Institute of Technology, Israel)
"Pancreatic Ductal Adenocarcinoma Nano-Diggers"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmAyelet David (Ben-Gurion University of the Negev, Israel)
"E-Selectin-Targeted Copolymer Attenuates the Development and Progression of both Atherosclerosis and Cancer"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmHelena Florindo R Ferreira (Osíris Travel, Portugal)
"Insights on the Impact of Controlled Multicomponent Nanoscale Systems on Immune Modulation Against Solid Tumors"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmBrynn Olden (University of Washington, USA)
"Cationic Polymers for Non-Viral Gene Delivery to Primary Human T Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmWilliam Payne (University of Nebraska Medical Center, USA)
"Computational Modeling of Polymeric Nanoparticles for Rational Design in Drug Delivery"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAbdullah Syed (University of Toronto, Canada)
"3D Mapping of Nanoparticles in Tumours"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA213845-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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