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Cellular and Molecular Mechanisms of Toxicity
Gordon Research Conference

Advanced Investigation in Mechanistic Toxicology

Dates

August 13-18, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Yanan Tian

Vice Chair:
John H. Richburg

Meeting Description

The Gordon Research Conference (GRC) on Cellular and Molecular Mechanisms of Toxicity is the premier forum for showcasing the latest, most innovative advances in mechanistic toxicological research. For the 2017 conference, the organizers have assembled a group of world-leading experts working on areas of investigation that are highly relevant to environmental, industrial, and pharmaceutical toxicology, with the goal of incorporating the molecular basis of disease into risk management and decision making. Emerging technologies in mechanistic toxicology and model and systems biology approaches to assessing risk to human disease will be highlighted along with the microbiome, epigenomics including noncoding RNA, application of new technology such as CRISPR/Cas9, and transgenerational mechanisms of toxicology. For the third consecutive time, a Gordon Research Seminar (GRS) on Cellular and Molecular Mechanisms of Toxicity will precede the conference. The GRS is organized and run by graduate students and fellows entirely and provides an expanded opportunity for trainees and young scientists to be exposed to cutting-edge science and to network with their future colleagues in the field. The poster session of the GRC is an essential element to the success of conference. Trainees and scientists at any level will have the opportunity to present their latest, groundbreaking work in poster format under an informal atmosphere that fosters relaxed dialog, networking and idea sharing. A special selection committee will select some abstracts/posters for short oral talks. These "late-breaking" oral sessions provide increased participation to trainees and young scientists to share their work with an audience of experts. This is a tremendous opportunity for the young talent to receive feedback from well-established leaders in the field. Another key to the success of the GRC is the social interaction of participants at meal times and during social activities in afternoon breaks. These interactions have led to long-lasting scientific collaborations and the lining up of trainees with laboratories for further education. We look forward to seeing you at the Gordon Research Conference on Cellular and Molecular Mechanisms of Toxicology in 2017!

Related Meeting

This GRC was held in conjunction with the "Cellular and Molecular Mechanisms of Toxicity" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: New Science and New Horizons in Mechanistic Toxicology
Discussion Leader: Charlene McQueen (University of Arizona, USA)
7:40 pm - 8:10 pmKenneth Ramos (University of Arizona Health Sciences, USA)
"Toxicogenomics in the Era of Precision Medicine"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmOliver Rando (University of Massachusetts Medical School, USA)
"Daddy Issues: Paternal Effects of Diet and Toxins on the Next Generation"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmXenobiotic Receptors and Their Novel Functions
Discussion Leader: Michael Gallo (Robert Wood Johnson Medical School, Rutgers University, USA)
9:00 am - 9:30 amGary Perdew (Pennsylvania State University, USA)
"Ah Receptor Is a Therapeutic Target for Drug-Induced Enteropathy"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMasahiko Negishi (National Institute of Environmental Health Sciences, NIH, USA)
"CAR Scaffolds GADD45B to Regulate Cell Signaling in HCC Development"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amWen Xie (University of Pittsburgh, USA)
"The Endobiotic Functions of Xenobiotic Receptors"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmLate-Breaking Topic
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Dana Dolinoy (University of Michigan, USA) and Karilyn Sant (University of Massachusetts, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic and Epigenetic Mechanisms of Toxicology
Discussion Leaders: Shaun McCullough (U.S. Environmental Protection Agency, USA) and Patrick Allard (University of California, Los Angeles, USA)
7:30 pm - 8:00 pmBrian Strahl (University of North Carolina at Chapel Hill, USA)
"Chromatin Mechanisms of Epigenetic Control"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmKari Nadeau (Stanford University, USA)
"Epigenetic Mechanisms of Air Pollution-Induced Immune Dysfunction in Children"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmRichard Woychik (National Institute of Environmental Health Sciences, NIH, USA)
"Understanding the Role of Repetitive Elements in Toxicity Responses"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNoncoding RNA and Their Roles in Regulating Toxic Responses
Discussion Leader: Frederick Tyson (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:30 amDana Dolinoy (University of Michigan, USA)
"piRNA Targeted DNA Methylation: Implication for Toxicological and Translational Sciences"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amChuan He (University of Chicago, USA)
"RNA Methylation in Gene Expression Regulation"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amChengfeng Yang (University of Kentucky, USA)
"Non-Coding RNAs and Metal Carcinogenesis"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmLate-Breaking Topic
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHumanized Models: Where Are We Now?
Discussion Leader: Heather Wallace (University of Aberdeen, United Kingdom)
7:30 pm - 8:00 pmMichael Brehm (University of Massachusetts Medical School, USA)
"Humanized Mouse Models – Success and Limitations"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMatthew Wright (Newcastle University, United Kingdom)
"Cell Replacement Therapies – iPSC or Transdifferentiation"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSilvia Guionaud (Drug Safety and Metabolism, AstraZeneca, United Kingdom)
"Translational In Vivo and In Vitro Models in Oncology Drug Development"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTick Tock Goes the Clock: Circadian Rhythm of Gut Microbiota Influences Host Metabolic and Drug Functions
Discussion Leader: Tamara Tal (U.S. Environmental Protection Agency, USA)
9:00 am - 9:30 amLora Hooper (University of Texas Southwestern Medical Center, USA)
"Epithelial Cell Contributions to Intestinal Immunity"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amVanessa Leone (University of Chicago, USA)
"Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amMingzhu Fang (Rutgers School of Public Health, USA)
"Central Role of Circadian Rhythm in Cellular Responses to Toxicants and Stressors"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmLate-Breaking Topic
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNon-Animal Methods in Toxicology: Novel Mechanisms and New Opportunities
Discussion Leader: Ruth Roberts (ApconiX, United Kingdom)
7:30 pm - 8:00 pmRebecca Clewell (ScitoVation, USA)
"Systems Toxicology: Linking Network Perturbation to Phenotypes"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJohn Colbourne (The University of Birmingham, United Kingdom)
"Taxogenomic Read Across: Predicting Human Toxicity Using Non-Animal Species"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmCaroline Ring (ToxStrategies, Inc., USA)
"Where Is the Risk? In Vitro-In Vivo Extrapolations (IVIVE) Using Reverse Toxicokinetics"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSystem Biological Approaches to Assessing Xenobiotic Responses
Discussion Leaders: Ronald Hines (Office of Research and Development, U.S. Environmental Protection Agency, USA) and Rhiannon Hardwick (Theravance Biopharma, USA)
9:00 am - 9:30 amStephen Edwards (U.S. Environmental Protection Agency, USA)
"An Integrative Data Mining Approach to Identify Adverse Outcome Pathway Signatures"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amCraig Rowlands (Underwriters Laboratories, USA)
"Increasing Confidence in Read Across Through Big Science"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amTing Wang (Washington University School of Medicine, USA)
"Evolution of Epigenetic Regulation in Vertebrate Genome"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amLate-Breaking Topic
11:45 am - 11:55 amDiscussion
11:55 am - 12:05 pmJun Kanno (Japan Bioassay Research Center, Japan)
"Percellome Toxicogenomics Project for Mechanism-Based Toxicity Prediction"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Mechanisms of Toxicity – A Path Forward
Discussion Leader: Michael Holsapple (Michigan State University, USA)
7:30 pm - 8:05 pmQuan Lu (Harvard T.H. Chan School of Public Health, USA)
"Genome-Wide CRISPR Library Screen Identifies a Transcriptional Repressor Complex that Suppresses Cellular ER Stress Response"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:55 pmCheryl Walker (Baylor College of Medicine, USA)
"Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for the conference was made possible (in part) by 1 R13 ES 028073-01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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