SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:00 pm | Michael Wolfe (Harvard University, Co-Chair) Opening remarks |
8:00 pm - 9:30 pm | The Role of ADAM and RIP Proteases in Development and Beyond |
| Phenotypes of the ADAM10 and presenilin conditional knockout mice |
| Discussion Leader: Atsuko Sehara-Fujisawa (Kyoto University) |
8:00 pm - 8:30 pm | Peter Dempsey (University of Michigan) "Role of ADAM10 in Intestinal Stem Cells and Crypt Homeostasis" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Jie Shen (Harvard University) "Presenilins in neurodegenerative dementia" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | ADAM- and RIP-Dependent Signaling Pathways |
| Involvement of α- and γ-secretases in Notch and other signaling pathways |
| Discussion Leader: Elaine Raines (University of Washington) |
9:00 am - 9:30 am | J.V. McCarthy (University College Cork) "Gamma-secretase diversifies its portfolio: A role for regulated intramembrane proteolysis in cytokine and growth factor signaling" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Rolf Postina (University of Mainz) "Regulation of ADAM-mediated shedding by G protein-coupled receptor" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Brendan Lee (Baylor College of Medicine) "NOTCHing the bone: From stem cells to cancer" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Christian Haass (Ludwig Maximillian University) "RIP by BACE1 and γ-secretase" |
12:15 am - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural Biology of RIP Proteases and Their Substrates |
| Insights into the structure/function of ADAMs and intramembrane proteinases |
| Discussion Leader: Irit Sagi (Weizmann Institute) |
7:30 pm - 7:40 pm | Irit Sagi (Weizmann Institute) "Overview: lessons learned from structural analyses of cell surface proteases" |
7:40 pm - 8:10 pm | Steven Blacklow (Harvard University) "Regulated and pathogenic proteolysis in Notch signal transduction" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:50 pm | Christoph Becker-Pauly (Johannes Gutenberg University) "Meprin metalloproteases: Structural features and substrate identification by proteomics" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Vincent Dive (Simopro/CEA) "New perspectives in the development of synthetic inhibitors of Metzincins"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Ectodomain Shedding |
| Factors that influence ADAM-dependent processing events |
| Discussion Leader: Joaquin Arribas (University of Valley de Hebron) |
9:00 am - 9:30 am | Eiichiro Nishi (Kyoto University) "Multiple pathophysiological roles of nardilysin, an enhancer of ectodomain shedding" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Avraham Yaron (Weizmann Institute) "Developmental control of axonal repulsion by ectodomain shedding" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Huizhu Fan (University of Medicine and Dentistry of New Jersey) "Roles of Noncatalytic Domains of TACE in Ectodomain Shedding" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Bruce Walcheck (University of Minnesota) "Role of leukocyte ADAM17 in the host response during infection" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Silvio Weber (Christian-Albrechts-Universität zu Kiel) "Targeting ADAM10 in adult mice lead to atopic skin disease and myeloproliferative disorder" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Substrate Recognition and Handling |
| Specificity and catalysis by α- and γ-secretases |
| Discussion Leader: Michael Wolfe (Harvard University) |
7:30 pm - 8:00 pm | Sinisa Urban (John Hopkins) "Rhomboid proteases: catalysis within the membrane" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Oliver Schilling (University of Freiburg) "Proteomic strategies for the characterization of cell surface proteolysis"/td> |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Bart de Strooper (Katholieke Universiteit Leuven) "Regulation and specificity of γ-secretase complexes" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RIP in Biomedicine |
| Emphasis on roles in cancer and neurobiology |
| Discussion Leader: Matthew Freeman (University of Cambridge) |
9:00 am - 9:30 am | Yueming Li (Sloan-Kettering Institute) "Endogenous and exogenous Modulation of γ-secretase" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Philip Wong (John Hopkins) "Attenuation of Regulated Intramembrane Proteolysis as a Potential Anti-amyloid Combination Therapy for Alzheimer's Disease" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Marsha Moses (Harvard University) "ADAM12: A non-invasive biomarker of breast cancer status, stage, and risk" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Roopali Roy (Harvard University) "ADAM12 isoforms can regulate breast tumor growth and progression" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Leann Brennaman (University of North Carolina, Chapel Hill) "ADAM10-dependent regulation of cortical interneuron development" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inhibitors of RIP and ADAMs |
| Clinical candidates that modulate ADAMs and RIP in disease states |
| Discussion Leader: Robert Newton (Incyte Corporation) |
7:30 pm - 8:00 pm | Robert Newton (Incyte Corporation) "Preclinical and clinical biology of aderbasib, a selective ADAM10 and ADAM17 inhibitor for the treatment of p95HER2+ breast cancer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Christian Siebel (Genetech) "Therapeutic Antibodies Modulating Notch Receptor Activation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Adolfo Ferrando (Columbia) "Targeting oncogenic NOTCH signaling in T-cell leukemia" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | α-, β- and γ-secretases: Targets for drug discovery |
| Target validation and the search for new clinical candidates |
| Discussion Leader: Amy Sang (Florida State University) |
9:00 am - 9:30 am | Joerg Bartsch (Marburg University) "The disintegrin domain of ADAM8 as major determinant in invasive pathologies" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Christopher Tape (Cambridge University) "Cross-Domain Inhibition of TACE" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Stefan Rose-John (Christian-Albrechts-Universität zu Kiel) "ADAM17 Orchestrates Pro- and Anti-Inflammatory Cytokine Activities" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Dustin Mergott (Eli Lilly) "Central Inhibition of Alzheimer's Beta-Secretase in Humans: Proof of Concept with LY2811376" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Richard Olson (Bristol-Myers-Squibb) "Designing Notch-sparing, brain penetrant gamma-secretase inhibitors: The discovery of BMS-708163" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 6:00 pm | Free Time |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lectures |
| Shedding and RIPping: proteolysis in and out of the membrane |
| Discussion Leader: Marcia Moss (BioZyme Inc) |
7:30 pm - 8:15 pm | Carl Blobel (Hospital for Special Surgery, NY) "ADAMs: key regulators of EGF-receptor signaling" |
8:15 pm - 8:30 pm | Discussion |
8:30 pm - 9:15 pm | Matthew Freeman (University of Cambridge) "Rhomboids: how they work and what they do" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |