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NOX Family NADPH Oxidases
Gordon Research Conference

NOX Molecular Insights Leading to Translation

Dates

June 5-10, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Francisco R.M. Laurindo

Vice Chair:
Ulla Knaus

Meeting Description

The 2016 NOX Family NADPH Oxidases Gordon Research Conference (NOX-GRC) features state-of-the-art unpublished work covering the multidisciplinary scope of NOX research, and will be preceded by a NOX Gordon Research Seminar (NOX-GRS) for research trainees, graduate students and post-doctoral fellows. NOX family proteins have emerged as major ubiquitous sources of reactive oxygen species with relevant signaling functions, implicated as powerful mechanisms of disease. This investigative area is moving forward at very high pace, with exciting advances at the molecular, cellular, physiological and clinical frontiers. NOX-GRC has firmly established as the premier forum for discussing state-of-the-art research in the area in a highly collegiate, collaborative and informal atmosphere. The 2016 NOX-GRC program is organized around the theme "Nox molecular insights leading to translation". Session topics include the molecular structure of NOX complexes, genetic/epigenetic regulation, NOX-mediated inflammation and metabolic regulation, novel modes of NOX regulation and translational studies on gastrointestinal, cardiovascular, neurologic diseases and cancer, including discussions on novel NOX inhibitors. In addition, a keynote session will feature broad and thought-provoking discussions on redox processes. NOX-GRC will provide a venue for innovative and paradigm-challenging presentations, given by internationally recognized experts and followed by ample time for discussions chaired by discussion leaders. This healthy interaction will be sustained and extended at poster sessions, focused on early-career investigators. The meeting was organized to reflect gender and geographic diversity of the field, and will allow for the inclusion of late-breaking science and speakers selected from trainee abstracts. The accompanying GRS features discussions on NOX-related science directed at young investigators and mentoring aspects of career development led by senior scientists, together with oral and poster presentations. The 2016 NOX-GRC will further consolidate the NOX scientific community to advance our investigation on this vigorously evolving area. Please join us on this exciting meeting!

Related Meeting

This GRC was held in conjunction with the "NOX Family NADPH Oxidases" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Thinking Outside of the BOX in NOX Signaling and Homeostasis
Biochemistry of heme-mediated electron transfer systems in biology; Understanding cellular redox events - targets and opportunities.
Discussion Leader: Robert Clark (University of Texas Health Science Center, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmMichael Marletta (University of California, Berkeley, USA)
"The Intersection of Heme Biochemistry, Nitric Oxide and Oxygen"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmUrsula Jakob (University of Michigan, USA)
"Understanding Cellular Redox Events - Targets and Opportunities"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNOX Activation: From Protein Structure to Subunit Assembly
Ferredoxin NADP+ reductase as a model system for flavoprotein-mediated electron transfer; Insights into assembly of the NADPH oxidase complex; NOX2 modulation of MHC-II antigen processing.
Discussion Leader: Edgar Pick (Sackler School of Medicine, Tel Aviv University, Israel)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amP. Andrew Karplus (Oregon State University, USA)
"Ferredoxin NADP+ Reductase as a Model System for Flavoprotein-Mediated Electron Transfer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amLaura Baciou (CNRS / University of Paris-Sud, France)
"Insights into Assembly of the NADPH Oxidase Complex"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:15 amNicolas Demaurex (University of Geneva, Switzerland)
"Mechanisms and Impact of Nox Activation in Intracellular Compartments of Immune Cells"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amAnny Slama-Schwok (Institut National de la Recherche Agronomique (INRA) / INSERM, France)
"Targeting the NADPH Site of NOX and NOS with Photoactive NADPH Derivatives: Structural Insights and Functional Implications"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmFranck Fieschi (Université Grenoble Alpes, France)
"Characterization of the Molecular Basis of Selectivity of NOXs Towards NADPH: NADPH Binding Mode in the NOX2 Active Site"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSharon O'Neill (University College Dublin, Ireland)
"Monitoring Conformational Dynamics of NADPH Oxidase Dimerization as a Novel Tool for Architecture-Based Screening"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNOXes and Microbial Sensing
NOX1-dependent epithelial microbial defenses and adaptation in the intestine; Microbial sensing, NETosis, and NOX in phagocytes.
Discussion Leader: Albert Van Der Vliet (University of Vermont, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmAndrew Neish (Emory University School of Medicine, USA)
"Nox1-Dependent Epithelial Microbial Defenses and Adaptation in the Intestine"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmStavros Selemidis (Monash University, Australia)
"Regulation of Virus Pathogenicity by Nox2 Oxidase"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmGabriella Aviello (National Children's Research Centre, Ireland)
"Redox Regulation of Enteric Infection and Inflammation"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetabolic and Inflammatory Mechanisms in NOX-Related Pathophysiology
NOXes as novel metabolic regulators; Mechanisms of NOX2-related inflammation in the central nervous system; Mechanisms and impact of NOX activation in intracellular compartments of immune cells.
Discussion Leader: Ulla Knaus (Conway Institute, University College Dublin, Ireland)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amAnna Zoccarato (King's College London, United Kingdom)
"Noxes as Novel Metabolic Regulators"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMenachem Rubinstein (Weizmann Institute of Science, Israel)
"How Does Endoplasmic Reticulum Stress Trigger Oxidative Stress and DNA Damage?"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amSimone Di Giovanni (Imperial College London, United Kingdom)
"Nox-Dependent Regulation of Nerve Regeneration"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amJaehyung (Gus) Cho (University of Illinois at Chicago, USA)
"Nox2 in Platelet-Neutrophil Interaction During Thromboinflammatory Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmDaniel Suter (Purdue University, USA)
"NOX2/CYBB Is Required for Retinotectal Development in Zebrafish"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMary Dinauer (Washington University in St. Louis School of Medicine, USA)
"A Role for NCF2 in the Genetic Predisposition to SLE: Studies in Lupus-Prone NZM.2329 Mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNOXes Under Pressure: Responses to Mechanobiological Stimuli and Cell Stress
NOX physiology and epigenetics in endothelial shear stress response and atherosclerosis; Reactive oxygen species-dependent mechanisms in flow-mediated vascular remodeling.
Discussion Leader: Kathy Griendling (Emory University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmHanjoong Jo (Emory University, USA)
"Role of Noxes in Flow-Dependent Regulation of Endothelial Inflammation and Atherosclerosis"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRoberto Sitia (Vita-Salute San Raffaele University, Italy)
"Stress Modulates NOX-Dependent H2O2 Signaling by Gating Aquaporin-8"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmCorinne Dupuy (Institut Gustave Roussy / CNRS, France)
"Role of NADPH Oxidase Duox1 in Thyroid Radiocarcinogenesis"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Modes of NOX Regulation
NRROS: A novel NOX2 regulator – role in host defense and autoimmunity; HACE-1 ubiquitin ligase and kinase-mediated Rac1 regulation in CNS pathophysiology; Redox regulation of RhoGTPases and implications in NOX-mediated signaling.
Discussion Leader: Miklos Geiszt (Semmelweis University, Hungary)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amWenjun Ouyang (Amgen Inc., USA)
"NRROS Regulates ROS Production and Plays an Essential Role in Neurological Homeostasis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amBo Rafn (BC Cancer Research Centre, Canada)
"HACE-1 Ubiquitin Ligase and Kinase-Mediated Rac1 Regulation in CNS Pathophysiology"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amRamnik Xavier (Massachusetts General Hospital, USA)
"Functional Genomics Discloses Novel Regulatory Nodes Controlling Nox2"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amSharon Campbell (University of North Carolina, USA)
"Redox Regulation of RhoGTPases and Implications in Nox-Mediated Signaling"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmChet Holterman (Kidney Research Centre, Ottawa Hospital Research Institute, Canada)
"Toll-Like Receptors and NADPH Oxidase 5 Activity: Oxidative Stress Takes a Toll on Renal Function"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMoo-Yeol Lee (Dongguk University, South Korea)
"Interplay Between Calcium and Reactive Oxygen Species in Vascular Smooth Muscle Angiotensin II Signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNOX Genetics and Epigenetics
Epigenetic regulation of NOXes; NOXes and cardiovascular phenotype of Williams Syndrome.
Discussion Leader: Mary Dinauer (Washington University in St. Louis School of Medicine, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmVictor Thannickal (University of Alabama at Birmingham, USA)
"Epigenetic Regulation of Noxes"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmBeth Kozel (National Heart, Lung, and Blood Institute, NIH, USA)
"Nox as a Modifier of Elastin-Mediated Vascular Disease"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmFrancis Miller (Duke University, USA)
"Integrated Micro-RNA Regulation of Nox4"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNOXes in the Pathogenesis and Progression of Cancer
Mechanisms of NOX 4-mediated protection against liver cancer; NOX-derived hydrogen peroxide and cancer pathophysiology; Interplay between NOXes and p53 in inflammation and cancer.
Discussion Leader: Corinne Dupuy (Institut Gustave Roussy / CNRS, France)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amIsabel Fabregat (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"A Mechanistic Approach to Nox4-Mediated Protection Against Liver Cancer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amKatrin Schroder (Goethe-Universität Frankfurt am Main, Germany)
"Nox-Derived Hydrogen Peroxide and Cancer Pathophysiology"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amThomas Leto (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Interplay Between Nox4 and p53 in Tumor Progression and Cancer Cell Migration"
11:15 am - 11:25 amDiscussion
11:25 am - 11:35 amRabii Ameziane El Hassani (Unité de Biologie et de Recherche Médicale, CNESTEN, Morocco)
"NADPH Oxidase NOX4 Is a Critical Mediator of BRAFV600E-Induced Down Regulation of the Sodium Iodide Symporter in Papillary Thyroid Carcinomas"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amKaramatullah Danyal (University of Vermont, USA)
"Role of Dual Oxidase1 in Regulation of Mitochondrial ROS Production for Wound Repair in Lung Epithelium"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmAlejandra Valdivia (Emory University, USA)
"NOX1 Regulates Polarity During Cell Migration"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJulie Brault (Universite Grenoble Alpes, France)
"Protein-Based Therapies for the Treatment of Chronic Granulomatous Disease: Proof-of-Concept on iPSC-Derived X0- and AR470-CGD Macrophages"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmNOX Inhibitors: Perspectives and Critical Analysis
High-throughput screening of a library of FDA-approved bioactive compounds as inhibitors of NADPH oxidase and pancreatic cancer; NOX inhibitors: first clinical studies and new developments.
Discussion Leader: David Lambeth (Emory University, USA)
5:30 pm - 5:40 pmIntroduction by Discussion Leader
5:40 pm - 6:05 pmJacek Zielonka (Medical College of Wisconsin, USA)
"High-Throughput Screening of a Library of FDA-Approved Bioactive Compounds as Inhibitors of NADPH Oxidase and Pancreatic Cancer"
6:05 pm - 6:15 pmDiscussion
6:15 pm - 6:30 pmPhilippe Wiesel (Genkyotex SA, Switzerland)
"Nox Inhibitors: First Clinical Studies and New Developments"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmPer Wikstrom (Glucox Biotech AB, Sweden)
"NOX Inhibitors in Development: Things to Consider"
6:55 pm - 7:05 pmDiscussion
7:05 pm - 7:20 pmPatrick Pagano (University of Pittsburgh, USA)
"Novel Nox Inhibitors: Challenges and Perspectives"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1 R13 AI124455-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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