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Drug Resistance
Gordon Research Conference

Experiences with Antimicrobials and Anticancer Agents, as Well as Herbicides and Pesticides

Dates

June 12-17, 2016

Location

University of New England
Biddeford, ME

Organizers

Chairs:
Manuel A. Navia & Pradipsinh K. Rathod

Vice Chairs:
Jean Patel & Jared A. Silverman

Meeting Description

This meeting will consider universal challenges of biological resistance to agents that are designed to improve human health and food production. A strong focus will be in the broad areas of drug resistance in infectious diseases – especially neglected diseases of the developing world – as well as drug resistance in cancer and in agricultural crop protection. Scientists working on antibacterials, antifungals, antiparasitics, antivirals, anticancer agents, as well as herbicides and insecticides used in the agricultural sector, will find the content relevant. Diverse participants from these orthogonal disciplines will be assembled; most of whom seldom interact directly for an extended period of time. The Conference setting will help break interdisciplinary barriers, help participants learn from one another, encourage uninhibited exploration, build long-lasting relationships and catalyze future transformative collaborations. Responses to seemingly unavoidable forces driving drug resistance require continual, creative scientific advances and tightly integrated discussions with global policy makers.

The success of this conference counts on a broad representation of disciplinary expertise, varying seniority, and wide geographic and cultural perspectives. As in previous years, we expect representation from academics, government organizations, and industry – small and large. Speakers and attendees with international reputation in drug resistance will bring experiences from many different countries and continents. In particular, the meeting leadership welcomes – and will seek out – timely and novel poster session presentations. These should benefit greatly from the GRC format. Fourteen outstanding poster presentations will be selected for short oral talks.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Threats and Responses
Discussion Leader: Manuel A. Navia (Oxford Bioscience Partners, USA)
7:40 pm - 8:20 pmDennis Dixon (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Antimicrobial Resistance: The Very Big Picture"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmRick Fairhurst (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Global Threat from Artemisinin Resistance in Malaria"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmUnderstanding Resistance
Discussion Leader: Lizbeth Hedstrom (Brandeis University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amRobert Douglas Sammons (The Monsanto Company, USA)
"Glyphosate Selects Novel Resistance Mechanisms Not Seen in Plants"
9:45 am - 10:00 amDiscussion
10:00 am - 10:15 amRuchi Anand (Indian Institute of Technology Bombay, India)
"Structural Insights into Antibiotic Regulation and Resistance in Streptomyces"
10:15 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:20 amMartin Burke (University of Illinois at Urbana-Champaign, USA)
"Non-Toxic Lipid-Binding Antifungal Combinations"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmAshley Vaughan (Center for Infectious Disease Research, USA)
"Tracking Malaria Drug Resistance Traits in Humanized Mice"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPaths to Stable Resistance Traits
Discussion Leader: Karen Allen (Boston University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:15 pmMarc Ouellette (Centre Hospitalier de l'Université Laval, Canada)
"Evolution of Drug Resistance in Leishmania"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmDavid Skurnik (Harvard Medical School, USA)
"Higher Fitness and Increased Pathogenicity in Resistant Organisms"
9:10 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAvoiding Resistance
Discussion Leader: Michael Cynamon (State University of New York Upstate Medical University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amEthan Settembre (Seqirus, USA)
"Influenza Vaccines for the 21st Century"
9:45 am - 10:00 amDiscussion
10:00 am - 10:15 amAaron Goldman (Harvard Medical School, USA)
"Multidrug Combinations in Cancer"
10:15 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:20 amAlejandro Vila (National University of Rosario, Argentina)
"Beta-Lactamase Inhibitors: A Renaissance"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmMariangela Bonizzoni (University of Pavia, Italy)
"Control of the Dengue Vectors Aedus aegypti and Aedus albopictus: Challenges of Insecticide Resistance and Alternative Methods"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdvancing Tools and Methods
Discussion Leader: Celia Schiffer (University of Massachusetts Medical School, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:15 pmHarren Jhoti (Astex Pharmaceuticals, United Kingdom)
"Fragment-Based Discovery of New Functional Binding Sites on Proteins"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmSriram Subramaniam (National Cancer Institute, NIH, USA)
"Cryo-EM of Cells, Viruses and Protein Complexes: Tools for Drug Discovery"
9:10 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExploiting Existing Resistance
Discussion Leader: Juswinder Singh (Ankaa Therapeutics, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amSkirmantas Kriaucionis (Oxford University, United Kingdom)
"Targeting Overexpressed CDA in Cancer Cells"
9:45 am - 10:00 amDiscussion
10:00 am - 10:15 amStephanie Reeve (University of Connecticut, USA)
"Trimethoprim Resistance in Clinically Isolated S. aureus"
10:15 am - 10:25 amDiscussion
10:25 am - 10:45 amCoffee Break
10:45 am - 11:25 amMargaret Riley (University of Massachusetts Amherst, USA)
"Bacteriocins: A Promising Alternative to Conventional Antibiotics"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amSooNee Tan (University of Washington, USA)
"Drug Dependent GSK2645947 Resistance in Plasmodium falciparum"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmTerence Crofts (Washington University in St. Louis, USA)
"Soil Amidases Allow Catabolism of Beta-Lactam Antibiotics by Environmental Bacteria"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTargeting Host Processes
Discussion Leader: Mariano Garcia-Blanco (University of Texas Medical Branch at Galveston, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:15 pmMichael Starnbach (Harvard Medical School, USA)
"Genomic Hunt for Host Determinants in Chlamydia Infections"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:10 pmAlexis Kaushansky (Center for Infectious Disease Research, USA)
"Targeting Liver Cell Biochemistry for Malaria Prophylaxis"
9:10 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGeneralizable Strategies: Combinations, Multi-Targeting, or Privileged Targets
Discussion Leader: Pradipsinh Rathod (University of Washington, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:45 amDidier Leroy (Medicines for Malaria Venture, Switzerland)
"Managing the Malaria Drug Resistance Portfolio"
9:45 am - 10:00 amDiscussion
10:00 am - 10:15 amNese Kurt Yilmaz (University of Massachusetts Medical School, USA)
"Improving Inhibitor Design to Counter Resistance: Lessons from HIV-1 and HCV Protease Inhibitors"
10:15 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:20 amMichael Cynamon (State University of New York Upstate Medical University, USA)
"Future Tuberculosis Therapy from an HIV Perspective"
11:20 am - 11:35 amDiscussion
11:35 am - 12:15 pmGautam Dantas (Washington University School of Medicine, USA)
"Networks Exchanging Antibiotic Resistance"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Connecting Paths to Patients
Discussion Leader: Jared Silverman (Kaleido Biosciences, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:15 pmKeith Jerome (Fred Hutchinson Cancer Research Center, USA)
"Towards CRISPR-Based Antiviral Treatments"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible in part by 1 R13 AI126685-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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