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Notch Signaling in Development, Regeneration & Disease
Gordon Research Conference

Notch Signaling: Phenotypes to Molecular Mechanisms

Dates

July 31 - August 5, 2016

Location

Bates College
Lewiston, ME

Organizers

Chairs:
Stephen Blacklow & Warren Pear

Vice Chairs:
Sarah J. Bray & Christian Siebel

Meeting Description

The 2016 Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease will provide a stimulating forum to discuss and disseminate new research, concepts and therapeutic opportunities at the forefront of Notch-related biology. Although the first "Notch phenotype" was described over a century ago, the central importance of the Notch pathway in many cell fate decisions, and in a wide range of human diseases is now established: mutations of core Notch pathway components underlie developmental syndromes, adult onset diseases, and cause or contribute to cancer. This meeting will stimulate cross-disciplinary discussions and collaborations among participating scientists in this critically important area of developmental biology and signaling, and nurture a developing sense of community among researchers in the field. The meeting will bring together scientists addressing fundamental mechanistic, developmental, clinical and therapeutic questions using diverse approaches. The invited participants include a blend of established and early career scientists with exciting new findings. Time is also set aside for short talks by poster presenters. The collegial and confidential atmosphere of this conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal environment for free scientific exchange. The inclusion of a Gordon Research Seminar (GRS) exclusively for postdocs and graduate students prior to the main conference will also draw new scientists into the field and encourage participation from trainees at all levels.

Related Meeting

This GRC was held in conjunction with the "Notch Signaling in Development, Regeneration & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Function to Structure
Discussion Leaders: Stephen Blacklow (Harvard Medical School, USA) and Warren Pear (University of Pennsylvania, USA)
7:40 pm - 8:10 pmJuergen Knoblich (Institute of Molecular Biotechnology, Austria)
"Mechanisms of Neural Development"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmK. Christopher Garcia (Stanford University School of Medicine, USA)
"Molecular Mechanisms of Developmental Signaling"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMechanistic Aspects of Notch Signaling
Discussion Leader: Sarah Bray (University of Cambridge, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amDavid Sprinzak (Tel Aviv University, Israel)
"Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amPenny Handford (University of Oxford, United Kingdom)
"Architecture of the Notch Extracellular Domain and Its Interactions with Ligands in the Presence and Absence of Phospholipids"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amCarl Blobel (Hospital for Special Surgery, Weill Cornell Medicine, USA)
"Dissecting the Contribution of ADAMs10 and 17 to Notch Signaling in Mice and Cells"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amRobert Haltiwanger (University of Georgia, USA)
"Regulation of Notch by Glycosylation"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amPaul Langridge (Columbia University, USA)
"The Role of Epsin-Mediated Ligand Endocytosis in Notch Activation"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmYoung-Wook Jun (University of California, San Francisco, USA)
"Regulation of Notch Signaling at the Cell Surface Through Receptor Spatial Organization"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNotch and Stem Cells
Discussion Leader: Ivan Maillard (University of Michigan, USA)
7:30 pm - 7:50 pmJudith Kimble (University of Wisconsin-Madison / Howard Hughes Medical Institute, USA)
"Notch Regulation of Stem Cells in C. elegans"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLinda Samuelson (University of Michigan, USA)
"Notch Pathway Regulation of Gastrointestinal Stem Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmThomas Rando (Stanford University, USA)
"Regulation of Stem Cell Quiescence and Activation by Notch Signaling"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJayaraj Rajagopal (Massachusetts General Hospital, USA)
"Notches, Niches, and Stem Cells"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNotch and Development
Discussion Leader: Ryoichiro Kageyama (Kyoto University, Japan)
9:00 am - 9:20 amOliver Pourquie (Harvard Medical School, USA)
"Notch and the Segmentation Clock"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAchim Gossler (Hannover Medical School, Germany)
"Analysis of Mammalian DLL Ligand Function"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amKim Dale (University of Dundee, United Kingdom)
"Notch/Shh Cross-Talk in Neural Cell Fate"
10:50 am - 11:00 amDiscussion
11:00 am - 11:10 amKumiko Kobayashi (Institute for Virus Research, Kyoto University, Japan)
"Single-Cell Quantification of Synchronized Oscillation in the Mouse Segmentation Clock"
11:10 am - 11:15 amDiscussion
11:15 am - 11:35 amRalf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Organ Specific Roles of Notch Signaling in the Vasculature"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amGinger Hunter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Mechanisms of Tissue Patterning by Notch-Mediated Long-Range Lateral Inhibition"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmEllen Rothenberg (California Institute of Technology, USA)
"Dissecting the Notch Signaling Network in T Lineage Commitment"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNotch and Cell Fate Choice
Discussion Leader: Irwin Bernstein (Fred Hutchinson Cancer Research Center, USA)
7:30 pm - 7:50 pmLuisa Iruela-Arispe (University of California, Los Angeles, USA)
"The Multiple Contributions of Notch to Vascular Homeostasis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAnna Bigas (Hospital del Mar Medical Research Institute (IMIM), Spain)
"Notch/Beta-Catenin Crosstalk in the Hematopoetic System"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDavid Traver (University of California, San Diego, USA)
"Iterative Roles for Notch Signaling in Hematopoetic Stem Cell Development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMark Chiang (University of Michigan, USA)
"Zmiz, a Direct Notch1 Cofactor"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNotch, Transcription, and Epigenetics
Discussion Leader: Christian Siebel (Genentech, Inc., USA)
9:00 am - 9:20 amJon Aster (Harvard Medical School / Brigham and Women's Hospital, USA)
"Notch Regulation of Gene Expression in Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTilman Borggrefe (University of Giessen, Germany)
"Notch Signaling Regulated by Chromatin Modifiers"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRhett Kovall (University of Cincinnati, USA)
"Structural Studies of CSL Transcription Complexes"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAdolfo Ferrando (Columbia University School of Medicine, USA)
"Notch in Leukemia"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amRaphael Kopan (Cincinnati Children's Hospital Medical Center, USA)
"Towards Single Cell, Quantitative Analyses of Notch Signalling"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSarah Bray (University of Cambridge, United Kingdom)
"Decoding the Notch Response"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLate-Breaking Topics
Short talks to be selected from abstracts.
Discussion Leader: Jon Aster (Harvard Medical School / Brigham and Women's Hospital, USA)
7:30 pm - 7:40 pmRussell Ryan (Massachusetts General Hospital, USA)
"Activation of Oncogene Enhancers by Notch Signaling in Small B Cell Lymphomas"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmRumela Chakrabarti (University of Pennsylvania, USA)
"Notch Ligand Regulation of Mammary Stem Cells and Tumor Initiation in Basal Breast Cancer"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmRoxana Wasnick (Justus Liebig University Giessen, Germany)
"The Role of Notch Signaling Pathway in the Etiology and Pathogenesis of Idiopathic Lung Fibrosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmBrian Gebelein (Cincinnati Children's Research Foundation, USA)
"The Co-Activator, Co-Repressor, CSL Concentration Ratios Are a Major Determinant of Cell-Specific Notch Transcriptional Outputs in Drosophila"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmWendell Lim (University of California, San Francisco, USA)
"Synthetic Biology of Signaling"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNotch, Cancer, and Therapeutics
Discussion Leader: Lucio Miele (LSU Health Sciences Center New Orleans, USA)
9:00 am - 9:20 amPhilip Jones (The Wellcome Trust Sanger Institute, United Kingdom)
"Pervasive Positive Selection of Oncogenic Notch Signaling in Squamous Pre-Cancer"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFreddy Radtke (École Polytechnique Fédérale de Lausanne, Switzerland)
"Lineage Repression Is Essential for T Cell Development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amBarbara Bedogni (Case Western Reserve University, USA)
"Notch in Melanoma Development and Progression"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amTian-Li Wang (Johns Hopkins University, USA)
"Effective Treatment of Platinum-Resistant Cancers by Targeting Notch"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amTimothy Hoey (OncoMed Pharmaceuticals, USA)
"Pre-Clinical and Clinical Development of Notch Pathway Antagonistic Antibodies"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmIvan Maillard (University of Michigan, USA)
"Role of Notch Signaling in T Cell Alloimmunity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmModulators of Signaling
Discussion Leader: Pamela Stanley (Albert Einstein College of Medicine, USA)
7:30 pm - 7:50 pmSusan Cole (Ohio State University, USA)
"Post-Transcriptional Regulation of Notch Pathway Components During Embryonic Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChristy Fryer (Novartis, USA)
"Identification and Characterization of Novel Modulators of Notch Signaling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMichael Elowitz (California Institute of Technology, USA)
"Notch Signaling at the Single Cell Level"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R13HD088000. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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