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Neurobiology of Brain Disorders
Gordon Research Conference

Changes in Normal Functions of the Nervous System Leading to Neurodegeneration

Dates

August 7-12, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chairs:
Luciano D'Adamio & Bart De Strooper

Vice Chairs:
David M. Holtzman & Cheryl Wellington

Meeting Description

Aging and genetic factors are the overwhelming causes of several neurodegenerative disorders. The commonness of these disorders is snowballing due to the increase in the human life span, making neuronal degenerative pathologies a serious public health problem. Growing evidence suggests that alterations of basic physiological processes may concur in the pathogenesis of several distinct neurodegenerative processes. This GRC aims to assemble leaders in the fields of basic and disease-focused neuroscience, as well as normal aging, to discuss how alterations of normal biological processes can lead, when altered, to pathophysiological consequences and neurodegenerative disorders. In this context, the conference aims to provide a platform in which artificial borders between basic and translational science are removed leading to synergistic interactions.

Related Meeting

This GRC was held in conjunction with the "Neurobiology of Brain Disorders" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Global Positioning System, APOE4 and Memory
Discussion Leader: Luciano D'Adamio (Albert Einstein College of Medicine, USA)
7:40 pm - 8:20 pmJohn O'Keefe (University College London, United Kingdom)
"GPS and Memory"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmThomas Sudhof (Stanford University, USA)
"ApoE Function in Neurons"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSeeding and Spreading of Proteopathic Seeds
Discussion Leader: John Trojanowski (University of Pennsylvania, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amVirginia Lee (University of Pennsylvania, USA)
"Transmission of Alpha-Synuclein in Synucleinopathies"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amLary Walker (Emory University, USA)
"The Prion Paradigm and Alzheimer's Disease"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amKaren Ashe (University of Minnesota, USA)
"Beyond Tangles: Synaptic and Cognitive Dysfunction Caused by Non-Fibrillar Tau"
11:30 am - 11:45 amDiscussion
11:45 am - 11:55 amYun-Ru Chen (Academia Sinica, Taiwan)
"The Discovery of Toxic TDP-43 Oligomers in TDP Proteinopathies"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmChiara Zurzolo (Pasteur Institute, France)
"Role of Tunneling Nanotubes in the Spreading of a-Syn Fibrils and Other Proteopathic Seeds"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmFrancesca-Fang Liao (University of Tennessee Health Science Center, USA)
"Can the Stress Regulating Heat Shock Factor HSF1 Be a Key Player in Synaptic Functions and Memory?"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenetic and Epigenetic Factors in Neurodegeneration
Discussion Leader: Bart De Strooper (VIB, KU Leuven, Belgium)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:30 pmAlison Goate (Icahn School of Medicine at Mount Sinai, USA)
"Role of Rare Variation in Risk for Alzheimer's Disease"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmAndrew Teich (Columbia University, USA)
"A Systems Approach to Studying Synaptic Dysfunction in AD"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmRafael Fernandez-Chacon (Instituto de Biomedicina de Sevilla (IBiS) / Universidad de Sevilla / CSIC / CIBERNED, Spain)
"Cysteine String Protein-a (CSP-a) Maintains the Postnatal Quiescence of Neural Stem Cells Through Inhibition of mTOR"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmLi-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA)
"Cell Type-Specific Epigenomic Analysis in the Neurodegenerating Brain"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmSynaptic Plasticity in Health and Disease
Discussion Leader: Pablo Castillo (Albert Einstein College of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amJie Shen (Harvard Medical School, USA)
"Presenilins and Alzheimer's Disease: New Insight into the Pathogenic Mechanism"
9:40 am - 9:55 amDiscussion
9:55 am - 10:25 amOttavio Arancio (Columbia University, USA)
"Rearranging the Puzzle: A New View on Alzheimer's Disease Pathogenesis"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:35 amInna Slutsky (Tel Aviv University, Israel)
"Transition Mechanisms from Physiology to Alzheimer's Disease Pathology"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amDieter Edbauer (German Center for Neurodegenerative Diseases (DZNE), Germany)
"The Role of TDP-43 in Trafficking and Signaling in Neurons"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmZohreh Farsi (Max-Planck Institute for Biophysical Chemistry, Germany)
"Single-Vesicle Imaging: A Novel Approach to Study the Vesicular Transporters and the Ion-Proton Exchangers on Synaptic Vesicles"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJerrah Holth (Washington University in St. Louis, USA)
"The Interaction Between Sleep and Tau Pathology in the P301S Tauopathy Mouse Model"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMitochondrial and Metabolic Dysfunction
Discussion Leader: Jie Shen (Harvard Medical School, USA)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:35 pmGiovanni Manfredi (Weill Cornell Medical College, USA)
"Mitochondria and Neurodegeneration"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmVanessa Morais (Institute of Molecular Medicine (IMM), University of Lisbon, Portugal)
"Quality Control Pathways of Neuronal Mitochondria"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:50 pmAmantha Thathiah (University of Pittsburgh School of Medicine, USA)
"GPCR Dysfunction in Alzheimer's Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation, Immunity and Neurodegeneration
Discussion Leader: David Holtzman (Washington University in St. Louis, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amChristian Haass (Ludwig Maximilians University of Munich / German Center for Neurodegenerative Diseases (DZNE), Germany)
"Cellular Mechanisms of Alzheimer's Disease"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amMorgan Sheng (Genentech, USA)
"The Role of Microglia in Neurodegeneration"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amHui Zheng (Baylor College of Medicine, USA)
"An NFkB and Complement-Mediated Neuron-Glia Signaling in Neuronal Health and Alzheimer's Disease"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amGreg Petsko (Weill Cornell Medical College, USA)
"How Parkinson's Disease Starts - And How It Might Be Stopped"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:25 pmBerislav Zlokovic (Keck School of Medicine of the University of Southern California, USA)
"Blood Brain Barrier: Cellular and Molecular Mechanisms of Neurodegeneration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAPOE4, BACE1 and Ataxin 2 as Therapeutic Targets
Discussion Leader: Karen Ashe (University of Minnesota, USA)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:45 pmJoachim Herz (University of Texas Southwestern Medical Center, USA)
"Targeting ApoE4 for the Prevention of Alzheimer's Disease"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmTien-Phat Huynh (Washington University School of Medicine, USA)
"Targeting Human APOE Using Antisense Oligonucleotides in APP Transgenic Mice"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmRobert Vassar (Northwestern University, USA)
"BACE1: The Beta-Secretase Enzyme in Health and Alzheimer's Disease"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmAaron Gitler (Stanford University, USA)
"Therapeutic Reduction of Ataxin 2 Extends Lifespan and Rescues Pathological Features of ALS in TDP-43 Transgenic Mice"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmBiomarkers and Therapeutics
Discussion Leader: Li-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amLeonard Petrucelli (Mayo Clinic College of Medicine, USA)
"C9orf72, Mechanisms of Toxicity and Therapeutic Potential"
9:35 am - 9:50 amDiscussion
9:50 am - 10:20 amDon Cleveland (Ludwig Institute for Cancer Research, USA)
"Gene Silencing Therapy for Human Neurodegenerative Disease"
10:20 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:35 amKaren Duff (Columbia University, USA)
"Tau Spread, Clearance and Therapeutics to Prevent It"
11:35 am - 11:50 amDiscussion
11:50 am - 12:20 pmLennart Mucke (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA)
"Mechanisms and Treatment of Neural Dysfunction in Alzheimer's Disease"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmProtein Homeostasis
Discussion Leader: Cheryl Wellington (The University of British Columbia, Canada)
6:00 pm - 6:05 pmIntroduction by Discussion Leader
6:05 pm - 6:25 pmPatrik Verstreken (VIB, KU Leuven, Belgium)
"Synaptic Protein Turnover for a Healthy Brain"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmMichael Lee (University of Minnesota, USA)
"Mutant Alpha-Synulcien Causes Postsynaptic Deficits by Inducing Tau Mislocalization to Dendritic Spines and AMPA Receptor Dysfunction"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmLi Gan (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA)
"Converging Pathways in AD and FTD"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSara Calafate (Janssen Pharmaceutica / Vlaams Instituut voor Biotechnologie (VIB), KU Leuven, Belgium)
"Synaptic Modulation of Tau Pathology Propagation"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLucia Chavez Gutierrez (VIB, KU Leuven, Belgium)
"PSEN Structural Metastability, Implications for Alzheimer's Disease"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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