Gordon Research Conferences
Meeting Details

Autophagy in Stress, Development & Disease (GRS)
Gordon Research Seminar

Autophagy: From the Bench to the Bedside, Basic Science Translated


March 19-20, 2016


Ventura Beach Marriott
Ventura, CA


Paolo Grumati & Anna Vainshtein

Meeting Description

This Gordon Research Seminar is designed by young scientists for young scientists to capture the latest advances in the field of autophagy from basic bench-based mechanistic research to the most cutting-edge autophagy-related therapeutics in a clinical setting.

Autophagy is an evolutionary conserved self-degradative mechanism that permits cells and tissues to better handle stressful stimuli. In particular, it is responsible for delivery of various cellular components and organelles to the lysosome for regular turnover or elimination. This biological mechanism is fast emerging as a vital cellular process with vast therapeutic implications. Indeed, dysfunctional autophagy is implicated in an ever-growing number of human pathologies including neurodegenerative, cardiovascular and metabolic diseases, myopathies, as well as cancer. In many instances modulation of aberrant autophagy has been proven sufficient to ameliorate symptoms and improve prognosis, thus setting the stage for the discovery of autophagy modulators with the purpose of treating disease.

Related Meeting

This GRS was held in conjunction with the "Autophagy in Stress, Development & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Growth by the mTOR Pathway
Discussion Leader: Anna Vainshtein (Baylor College of Medicine, USA)
3:45 pm - 4:20 pmDavid Sabatini (Whitehead Institute for Biomedical Research, USA)
"Growth by the mTOR Pathway"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulatory Mechanisms of Autophagy
Discussion Leaders: Manuela Antonioli (Freiburg Institute for Advanced Studies, University of Freiburg, Germany) and Thomas Riffelmacher (University of Oxford, United Kingdom)
7:30 pm - 7:45 pmJi-Man Park (University of Minnesota, USA)
"Mechanism of ULK1 Signaling to the ATG14-Containing VPS34 Complex in the Autophagy Induction Pathway"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAkinori Yamasaki (Institute of Microbial Chemistry, Japan)
"Structural Mechanisms Underlying Receptor-Mediated Selective Autophagy of Aggregated Aminopeptidase I"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmLeila Peraro (Tufts University, USA)
"Design and Synthesis of Constrained Peptides for the Induction of Autophagy"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMario Mauthe (University Medical Center Groningen, The Netherlands)
"Viral Infections Reveal the Extent of Unconventional Functions of the Autophagy Proteome"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShannon Nicolson (University of South Australia, Australia)
"Screens to Identify Putative Regulators of Autophagy-Dependent Cell Death in Drosophila"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmConstanza Cortes (University of California, San Diego, USA)
"Skeletal Muscle Autophagy and the Control of Systemic Metabolism: A Role for Transcription Factor E-B (TFEB) Signaling"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amPhysiological and Pathological Role of Autophagy
Discussion Leaders: Maged Harraz (The Johns Hopkins University, USA) and Joelle Magne (Karolinska Institutet, Sweden)
9:00 am - 9:15 amCoralie Daussy (CNRS, France)
"Autophagy Restricts HIV-1 Infection by Selectively Degrading Tat in CD4 T Lymphocytes"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amJeong-A Lim (National Institutes of Health, USA)
"Autophagy and mTOR Signaling in Pompe Disease"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amGisela Otten (Newcastle University, United Kingdom)
"Oxidation-Dependent Regulation of the Autophagy Receptor Sqstm1/p62 and Its Potential Role in Amyotrophic Lateral Sclerosis (ALS)"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amFengjuan Wang (Institut de Biologie Moléculaire et Cellulaire, CNRS, France)
"P140 Peptide Targets Deregulated Chaperone-Mediated Autophagy for Lupus Therapy"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJeffrey Willy (Indiana University School of Medicine, USA)
"Identification of Novel UPR Member IBTKa: Linking Autophagosome Formation and Secretion to the Pathogenesis of Non-Alcoholic Steatohepatitis"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amMorten Luhr (University of Oslo, Norway)
"Deciphering How Calcium and ER Stress Responses Affect Autophagy in Cancer Cells"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmAutophagy at a Glance
Discussion Leader: Paolo Grumati (Goethe University Frankfurt, Germany)
1:30 pm - 2:05 pmSharon Tooze (Francis Crick Institute, United Kingdom)
"Trafficking Regulators in Autophagosome Formation"
2:05 pm - 2:15 pmDiscussion
2:15 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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