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Cardiac Regulatory Mechanisms (GRS)
Gordon Research Seminar

Innovative Answers to Classic Cardiac Questions

Dates

June 4-5, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chairs:
Jerry Curran & Ronald J. Vagnozzi

Meeting Description

The Gordon Research Seminar on Cardiac Regulatory Mechanisms is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2016 Cardiac Regulatory Mechanisms GRS will focus on how technological advances, novel experimental models, and next generation platforms are being leveraged to uncover new and unexpected insights into the 'established' paradigms of cardiac biology. Junior scientists, trainees, and fellows who are using novel and interdisciplinary approaches to further understand the physiology and pathologies of the heart are encouraged to apply. The 2016 GRS will also include a special emphasis panel and forum discussion with leaders in both academia and industry, who will share their unique experiences on how to successfully drive high-impact basic and translational research programs in the academic, pre-clinical, or clinical arenas.

Related Meeting

This GRS was held in conjunction with the "Cardiac Regulatory Mechanisms" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmShifting Paradigms and Evolving Mechanisms in Cardiac Biology
Discussion Leader: Shirin Doroudgar (Heidelberg University Hospital, Germany)
3:45 pm - 3:55 pmSarah Schumacher (Temple University School of Medicine, USA)
"Domain-Specific Roles for GRK2 in Cardiac Hypertrophy and Heart Failure"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 4:10 pmJillian Simon (University of Oxford, United Kingdom)
"Redox-Dependent Dimerization of PKA RI Regulates Calcium Handling Under Physiological Conditions"
4:10 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmSathya Unudurthi (The Ohio State University, USA)
"The Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBasic Discovery to Inform Human Cardiovascular Health and Disease / Mentorship Component: Panel Discussion
Discussion Leaders: Samuel Buxton (Baylor College of Medicine, USA), Jessica Caldwell (University of Manchester, United Kingdom) and Jerry Curran (Abiomed, Inc., USA)
7:30 pm - 7:45 pmNieves Gomez-Hurtado (Vanderbilt University, USA)
"CaMKII-Dependent RyR2 Regulation in Arrhythmogenic CaM Syndromes"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmElaine Wan (Columbia University, USA)
"Incomplete Sodium Channel Inactivation Causes Spontaneous Atrial Fibrillation In Vivo and Ex Vivo in a Novel Mouse Model"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmKlemen Ziberna (University of Oxford, United Kingdom)
"Myocardial Overexpression of GTP Cyclohydrolase 1 Promotes Atrial Arrhythmias"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:30 pmPanel Discussion
"Project to Patent and Everything in Between: Hitting the Major Milestones of a Successful Research Program"
  • Peter Mohler (The Ohio State University College of Medicine, USA)
  • Walter Koch (Temple University, USA)
  • Donald Bers (University of California, Davis, USA)
  • Suguna Rachakonda (NIH Center for Accelerated Innovations, Cleveland Clinic, USA)
  • Gordon Pipes (Bristol-Myers Squibb, USA)
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMolecular Regulation of Cardiac Function and Dysfunction / The Dynamic Molecular World Outside the Cardiomyocyte
Discussion Leaders: Alexei Ilinykh (Monash University, Australia), Christopher Traynham (Temple University, USA), Pearl Quijada (University of Rochester Medical Center, USA) and Elza van Deel (VU University Medical Center, The Netherlands)
9:00 am - 9:15 amDavid Ryba (University of Illinois at Chicago, USA)
"Functional and Morphological Improvements Mediated by Long-Term ß-Arrestin Biased Agonism of the AT1R in Familial Dilated Cardiomyopathy"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amStephen Hurst (Thomas Jefferson University, USA)
"Truncation of GSK-3 Beta in the Mitochondria Matrix Is the Master Switch of the mPTP"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amRandi Parks (National Heart, Lung, and Blood Institute, NIH, USA)
"Regulation of the Permeability Transition Pore Is Altered in Mice Lacking the Mitochondrial Calcium Uniporter"
9:55 am - 10:00 amDiscussion
10:00 am - 10:05 amGeneral Discussion
10:05 am - 10:15 amJennifer Schwanekamp (Cincinnati Children's Hospital Medical Center, USA)
"Defining the Role of Transforming Growth Factor, Beta-Induced (BigH3) in Adverse Ventricular Remodeling"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amCelinda Kofron (Rhode Island Hospital / Alpert Medical School, Brown University, USA)
"Regulation of Cardiomyocyte Electrical Activity by Cardiac Fibroblasts in Innovative 3D In Vitro Cellular Cross-Talk Platforms"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amEmma Radcliffe (University of Manchester, United Kingdom)
"Heart Failure: A Nervous Approach"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmKeynote Session: Genome-Wide Discovery at the Forefront of Cardiac Biology
Discussion Leader: Ronald Vagnozzi (Cincinnati Children's Hospital Medical Center, USA)
1:30 pm - 1:45 pmCatherine Makarewich (University of Texas Southwestern Medical Center, USA)
"Identification and Characterization of Novel Cardiac and Skeletal Muscle Specific Micropeptides"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:20 pmElizabeth McNally (Northwestern University, USA)
"Dissecting the Genetic Drivers of Cardiomyopathy at the Genomic Scale"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible, in part by1R13AG054044-01 from National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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