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Endothelial Cell Phenotypes in Health & Disease (GRS)
Gordon Research Seminar

Balancing Endothelial Stability and Activation: Development, Disease, and Repairing Damage

Dates

July 16-17, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Erich Kushner

Meeting Description

The Gordon Research Seminar on Endothelial Cell Phenotypes in Health and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This meeting will cover topics encompassing how extrinsic and intrinsic factors shape blood vessel formation during development and in tissue repair. We will also discuss how the homeostatic mechanisms that maintain proper vessel pattern and function are disrupted in disease states. The organizers strongly encourage attendees to present work that is unpublished and/or in progress, if possible.

Related Meeting

This GRS was held in conjunction with the "Endothelial Cell Phenotypes in Health & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Endothelial Collective Cell Migration
Discussion Leader: Victoria Bautch (The University of North Carolina at Chapel Hill, USA)
3:15 pm - 3:55 pmKaren Hirschi (Yale School of Medicine, USA)
"How Endothelial Cells Make Blood"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmBlood Vessels in Disease and Wound Healing
Discussion Leader: Christopher Hughes (University of California, Irvine, USA)
5:30 pm - 5:45 pmJames McCann (University of North Carolina at Chapel Hill, USA)
"A Mouse Model for Tracking and Auditing Endothelial Cell-Derived Extracellular Vesicles in Health and Disease"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmEmma Watson (Walter and Eliza Hall Institute of Medical Research, Australia)
"Pro-Survival Protein MCL1 Is Essential for Endothelial Cell Survival During Angiogenesis"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmKerrie Collins (University of Illinois at Chicago, USA)
"Septins Regulate Endothelial Cell Podosome Formation and Matrix Degradation"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmLilian Schimmel (Sanquin Research, The Netherlands)
"The Endothelium Actively Prevents Local Vascular Leakage During Leukocyte Extravsation"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmRoberto Villasenor (Roche Innovation Center Basel, Switzerland)
"Defining the Endocytic Phenotype of Endothelial Cells at the Blood-Brain Barrier"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmAnne Karine Lagendijk (Institute for Molecular Biology, University of Queensland, Australia)
"Live-Imaging of Tension Through Zebrafish VE-Cadherin Uncovers Mechanical Contributions in Artery Maturation and Cavernous Malformation"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMentorship Component: Career Panel / Mechanisms of Blood Vessel Patterning and Remodeling
Discussion Leader: Christiana Ruhrberg (University College London, United Kingdom)
9:00 am - 10:00 amPanel Discussion
"Advice and Guidance from New and Established Academic Investigators as Well as Industry Professionals"
  • Victoria Bautch (The University of North Carolina at Chapel Hill, USA)
  • Sunday Oladipupo (Lilly Research Laboratories, USA)
  • Christiana Ruhrberg (University College London, United Kingdom)
10:00 am - 10:15 amKrista Heinolainen (University of Helsinki / Wihuri Research Institute, Finland)
"VEGFR3 Modulates Vascular Permeability by Regulating VEGF/VEGFR2 Signaling"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amAnastasia Lampropoulou (UCL Institute of Ophthalmology, University College London, United Kingdom)
"VEGF165-Induced Vascular Permeability Relies on Both NRP1 and VEGFR2 for ABL-Mediated SRC Activation"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amUrs Langen (Max Planck Institute for Molecular Biomedicine, Germany)
"Specialized Endothelial Cell Subpopulations Drive Bone Development via Cell-Matrix Signaling"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmPhysical Forces in Endothelial Regulation and Morphogenesis
Discussion Leader: Mark Kahn (University of Pennsylvania, USA)
1:30 pm - 1:45 pmAndrew Chang (Red-Horse Lab, Stanford University, USA)
"Artery Growth and Stabilization Is Balanced by Mechanoregulation of Dach1"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmDrew Glaser (Washington University, USA)
"A Microfluidic Model of the Bone Marrow Endothelium and Microenvironments"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmQuinton Smith (Johns Hopkins University, USA)
"Elucidating the Effects of Shear and Substrate Rigidity on Human Induced Pluripotent Stem Cells"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13HL134188-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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