Gordon Research Conferences
Meeting Details

Intermediate Filaments (GRS)
Gordon Research Seminar

Breaking Barriers in Intermediate Filament Biology: From Structure to Mechanisms and Targets in Human Diseases


June 11-12, 2016


Stoweflake Conference Center
Stowe, VT


Iris Lähdeniemi & Noam Zuela

Meeting Description

Recent biomedical research has shown that a large number of human diseases ranging from skin disorders to dilated cardiomyopathy and premature aging diseases are caused by mutations in specific intermediate filament proteins. Intermediate Filaments (IF) are comprised of cytoskeletal and nucleoskeletal proteins that play a key role in determining cell shape and nuclear architecture; they are also involved in the modulation and propagation of signals within cells and in the regulation of cell motilty. The 2016 Gordon Research Seminar (GRS) will bring graduate students and postdoctoral fellows to discuss their most recent findings and how to tackle specific research problems as well as techniques and methods. The Gordon Research Seminar on Intermediate Filaments is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education. This forum provides an unprecedented opportunity for new investigators to present and exchange data and cutting edge ideas. Prominent senior scientists in the field will participate in the seminar as discussion leaders in some of the sessions. The topics of this meeting will focus on a wide range of studies on the structure and function of intermediate filaments (IFs) using biophysical, cell and molecular biological techniques. The goal of this seminar is to:

  • Provide an up-to-date overview of the structure and function of all intermediate filament proteins and how they are involved in human disease, with special emphasis on themes and issues that timely and topical.
  • Provide a venue for graduate students and postdoctoral fellows to discuss their current research in platform and poster sessions, and give them an opportunity to obtain valuable feedback from both peers and the expert mentors who will be invited to the GRS. These interactions will be focused on problem solving and applications and use of state-of-the-art techniques.
  • Provide a discussion forum for career development in areas related to the field.

Related Meeting

This GRS was held in conjunction with the "Intermediate Filaments" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.


Final Meeting Program

2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Back to the Future with Intermediate Filaments
Discussion Leader: Iris Lähdeniemi (Åbo Akademi University, Finland)
3:45 pm - 4:15 pmRobert Goldman (Northwestern University, USA)
"The Past, the Present and the Very Exciting Future of Intermediate Filament Research"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntermediate Filaments in Mechanisms and Targets of Human Disease
Discussion Leader: Zhuo Gan (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:45 pmEmma van Bodegraven (Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands)
"The Role of GFAP Isoforms in Astrocytoma Malignancy"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmPonnuswamy Mohanasundaram (Åbo Akademi University, Finland)
"Vimentin Regulates Cell Size Through the Insulin/mTOR Signaling Pathway"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmJi Young Choi (University of Maryland, USA)
"Investigation of the Role of the Canonical Wnt/ß-Catenin Signaling Pathway During Osteogenic Differentiation and Bone Quality in Hutchinson-Gilford Progeria Syndrome"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmRishel Vohnoutka (University of Massachusetts Lowell, USA)
"GSK3ß Phosphorylation of Serine 493 Within Neurofilament Heavy Chain Promotes KSP Phosphorylation Thereby Regulating Steady State Neurofilament Levels"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmPratik Chaudhari (Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), India)
"Role of Hemidesmosomal Linker Proteins in Neoplastic Progression of Squamous Cell Carcinomas"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAbigail Zieman (Johns Hopkins Bloomberg School of Public Health, USA)
"Palmoplantar Keratoderma Occurs Independent of Strain Background and Is Minimally Impacted by the Loss of IL-1R- or Tlr3-Dependent Signaling in Keratin 16 Null Mice"
9:25 pm - 9:30 pmDiscussion
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNuts and Bolts: Emerging Methods in Intermediate Filament Biology
Discussion Leader: Luiza Stankevicins (Saarland University, Germany)
9:00 am - 9:15 amCecilia Sahlgren (Eindhoven University of Technology, The Netherlands / Åbo Akademi University, Finland)
"Squeezing out Cellular Functions of IFs by Unconventional Methods"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMaria Jones (University of Missouri, USA)
"Deciphering the Role of the Highly Conserved Amino Subdomain of the Tail Domain of Neurofilament Medium"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amSangkyun Cho (University of Pennsylvania, USA)
"As the Beating Heart Stiffens in Development, So Does the Nuclear Lamina"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amTerhi Helenius (Åbo Akademi University, Finland)
"Keratins Are Altered in Intestinal Disease-Related Stress Responses"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amMelanie Homberg (University of Leipzig, Germany)
"Temperature Sensitivity of Keratin Mutations"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amFrederik Fleissner (Max Planck Institute for Polymer Research, Germany)
"Microspectroscopy of Intermediate Filament Secondary Structure Under Load"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Scientific Publishing
Discussion Leader: Noam Zuela (Hebrew University of Jerusalem, Israel)
1:30 pm - 2:10 pmBishr Omary (University of Michigan, USA)
"From Hypothesis to Publication: Ready, Get Set, Go!"
2:10 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by (1 R13 AR069967-01) from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS) and all co-funding support provided by the National Eye Institute (NEI) and the National Cancer Institute (NCI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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