| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Linking Voltage Sensor Movement with Physiological Dysfunction |
| Discussion Leader: Alexander Kintzer (University of California, San Francisco, USA) |
| 3:45 pm - 4:00 pm | Wandi Zhu (Washington University in St. Louis, USA)
"Mechanisms of Non-Covalent β Subunit Regulation of NaV Channel Gating and Pharmacology" |
| 4:00 pm - 4:10 pm | Discussion |
| 4:10 pm - 4:25 pm | Colin Peters (Simon Fraser University, Canada)
"A Voltage Sensor Model of the Cardiac Voltage-Gated Sodium Channel" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mechanisms of TRPV Channel Regulation / Keynote Session: Evolutionary Adaptations of
Voltage-Dependent Potassium Channels from an Antarctic Organism |
| Discussion Leader: Claudia Alvarez Baron (University of Wisconsin-Madison, USA) |
| 7:30 pm - 7:45 pm | Bo Hyun Lee (University of California, Davis, USA)
"Anomalous Mole Fraction Effect (AMFE) Measurements Indicated that TRPV1 Has a Flexible Pore" |
| 7:45 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:10 pm | Rocio Servin-Vences (Max Delbrück Center for Molecular Medicine, Germany)
"TRPV4 and PIEZO1 Are Activated by Different Mechanical Inputs in Chondrocytes" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:30 pm | Willem Laursen (Yale University, USA)
"Diminished Heat Sensitivity of TRPV1 Supports Heat Tolerance in Ground Squirrels and Camels" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:15 pm | Teresa Giraldez (La Laguna University, Spain)
"Evolutionary Adaptations of Voltage-Dependent Potassium Channels from an Antarctic Organism" |
| 9:15 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Probing the Enigmatic Ligand-Gated Ion Channel / Mentorship Component: Career Panel |
| The Mentorship Component will feature a panel of career scientists from varying backgrounds holding an open discussion forum on navigating a scientific career. |
| Discussion Leader: Anna Carbone (NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin / FMP Berlin, Germany) |
| 9:00 am - 9:15 am | Ljudmila Katchan (Leibniz Institute for Molecular Pharmacology, Germany)
"Structural Dynamics of an AMPA-Subtype Glutamate Receptor Revealed by State-Dependent FRET" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Varun Tiwari (University of Wisconsin-Madison, USA)
"Radial Tilting of the Extracellular Domain of GLIC Revealed by EPR Spectroscopy" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Simone Mazzaferro (Mayo Clinic, USA)
"Single Channel Features of (a4β2)2a4 and (a4β2)2β2 nAChRs" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 11:00 am | Panel Discussion |
| "Personal Perspectives on Scientific
Careers" |
|
- Stephan Pless (University of Copenhagen, Denmark)
- Shai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
- Teresa Giraldez (La Laguna University, Spain)
|
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Exciting Steps in Ion Channel Biophysics |
| Discussion Leader: Christian Peters (University of California, San Francisco, USA) |
| 1:30 pm - 1:45 pm | Teresa Aman (University of Washington, USA)
"Cyclic Nucleotide-Regulated Channels Studied with tmFRET and the Noncanonical Amino Acid, Anap" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Timothy Lynagh (University of Copenhagen, Denmark)
"Ion Selectivity in Acid-Sensing Ion Channel 1a" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Shao-Qing Zhang (University of California, San Francisco, USA)
"De Novo Design of a Transition-Metal Ion Channel" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
