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Ion Channels (GRS)
Gordon Research Seminar

Exploring the Molecular Basis of Cellular Excitability

Dates

July 9-10, 2016

Location

Mount Holyoke College
South Hadley, MA

Organizers

Chairs:
David K. Jones & Anna L. Carbone

Meeting Description

The Ion Channels GRS is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Attendees will discuss exciting new science and techniques related to ion channel regulation, structure, and function in the absence of the often-intimidating presence of senior scientists. Additionally, a small but select group of established researchers from academic, government, and industry backgrounds will provide scientific and career mentorship for all attendees.

Related Meeting

This GRS was held in conjunction with the "Ion Channels" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmLinking Voltage Sensor Movement with Physiological Dysfunction
Discussion Leader: Alexander Kintzer (University of California, San Francisco, USA)
3:45 pm - 4:00 pmWandi Zhu (Washington University in St. Louis, USA)
"Mechanisms of Non-Covalent β Subunit Regulation of NaV Channel Gating and Pharmacology"
4:00 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmColin Peters (Simon Fraser University, Canada)
"A Voltage Sensor Model of the Cardiac Voltage-Gated Sodium Channel"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of TRPV Channel Regulation / Keynote Session: Evolutionary Adaptations of Voltage-Dependent Potassium Channels from an Antarctic Organism
Discussion Leader: Claudia Alvarez Baron (University of Wisconsin-Madison, USA)
7:30 pm - 7:45 pmBo Hyun Lee (University of California, Davis, USA)
"Anomalous Mole Fraction Effect (AMFE) Measurements Indicated that TRPV1 Has a Flexible Pore"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:10 pmRocio Servin-Vences (Max Delbrück Center for Molecular Medicine, Germany)
"TRPV4 and PIEZO1 Are Activated by Different Mechanical Inputs in Chondrocytes"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmWillem Laursen (Yale University, USA)
"Diminished Heat Sensitivity of TRPV1 Supports Heat Tolerance in Ground Squirrels and Camels"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmTeresa Giraldez (La Laguna University, Spain)
"Evolutionary Adaptations of Voltage-Dependent Potassium Channels from an Antarctic Organism"
9:15 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amProbing the Enigmatic Ligand-Gated Ion Channel / Mentorship Component: Career Panel
The Mentorship Component will feature a panel of career scientists from varying backgrounds holding an open discussion forum on navigating a scientific career.
Discussion Leader: Anna Carbone (NeuroCure Cluster of Excellence, Charité - Universitätsmedizin Berlin / FMP Berlin, Germany)
9:00 am - 9:15 amLjudmila Katchan (Leibniz Institute for Molecular Pharmacology, Germany)
"Structural Dynamics of an AMPA-Subtype Glutamate Receptor Revealed by State-Dependent FRET"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amVarun Tiwari (University of Wisconsin-Madison, USA)
"Radial Tilting of the Extracellular Domain of GLIC Revealed by EPR Spectroscopy"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amSimone Mazzaferro (Mayo Clinic, USA)
"Single Channel Features of (a4β2)2a4 and (a4β2)2β2 nAChRs"
9:55 am - 10:00 amDiscussion
10:00 am - 11:00 amPanel Discussion
"Personal Perspectives on Scientific Careers"
  • Stephan Pless (University of Copenhagen, Denmark)
  • Shai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
  • Teresa Giraldez (La Laguna University, Spain)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmExciting Steps in Ion Channel Biophysics
Discussion Leader: Christian Peters (University of California, San Francisco, USA)
1:30 pm - 1:45 pmTeresa Aman (University of Washington, USA)
"Cyclic Nucleotide-Regulated Channels Studied with tmFRET and the Noncanonical Amino Acid, Anap"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmTimothy Lynagh (University of Copenhagen, Denmark)
"Ion Selectivity in Acid-Sensing Ion Channel 1a"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmShao-Qing Zhang (University of California, San Francisco, USA)
"De Novo Design of a Transition-Metal Ion Channel"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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