| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: The Lysosome in Nutrient Sensing and Cellular Growth Control |
| Discussion Leaders: Ralf Leonhardt (Yale University School of Medicine, USA) and Peace Atakpa (University of Cambridge, United Kingdom) |
| 3:45 pm - 4:15 pm | Roberto Zoncu (University of California, Berkeley, USA)
"The Lysosome in Nutrient Sensing and Cellular Growth Control" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Basic Principles of the Endo-Lysosomal System |
| Discussion Leaders: Gillian Griffiths (Cambridge Institute for Medical Research, United Kingdom) and Tess Shideler (University of New Mexico, USA) |
| 7:30 pm - 7:45 pm | Zachary Weinberg (Carnegie Mellon University, USA)
"Clathrin-Coated Pit Lifetimes Regulate Discrete Phases in GPCR Signaling" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Kelsie Eichel (University of California, San Francisco, USA)
"Mechanism and Signaling Consequences of Independent β-Arrestin and Receptor Trafficking" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Danielle Johnson (Hospital for Sick Children, Canada)
"Not All Lysosomes Are Created Equal" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Carlos Guardia (National Institutes of Health, USA)
"Coupling to Different Kinesin Motors Directs Regional Movement of Lysosomes Along Distinct Microtubule Tracks" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Thomas McWilliams (University of Dundee, United Kingdom)
"Mito-QC Illuminates Lysosomal Turnover of Mitochondria In Vivo" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Srigokul Upadhyayula (Harvard Medical School, USA)
"Cellular Dynamics Imaged in Real Time and in 3D Using Lattice Light-Sheet Microscopy" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Inter-Organelle Contacts and Vesicular Sorting |
| Discussion Leaders: Lois Weisman (University of Michigan, USA), Icten Meras (McGill University, Canada) and Olivia Majer (University of California, Berkeley, USA) |
| 9:00 am - 9:15 am | Ewan MacDonald (University of Liverpool, United Kingdom)
"Actin Mediated Receptor Recycling and Ubiquitin Mediated Receptor Degradation Are Functionally Coupled and Dynamically Opposed at the Endosome" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Frances Tilley (University of Bristol, United Kingdom)
"Polycystin-2 Trafficking: A Role for Retromer" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | General Discussion |
| Mentorship Component: Career Panel |
| 10:00 am - 11:00 am | Panel Discussion |
| "Building Your Career" |
|
- Gillian Griffiths (Cambridge Institute for Medical Research, United Kingdom)
- Roberto Weigert (National Cancer Institute, NIH, USA)
- Lois Weisman (University of Michigan, USA)
- Roberto Zoncu (University of California, Berkeley, USA)
|
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Membrane Trafficking in Health and Disease |
| Discussion Leaders: Roberto Weigert (National Cancer Institute, NIH, USA) and Debrup Sengupta (Yale School of Medicine, USA) |
| 1:30 pm - 1:45 pm | Maria Bagh (National Institute of Child Health and Human Development, NIH, USA)
"Defining Lysosomal Acidification Defect in a Mouse Model of a Neurodegenerative Lysosomal Storage Disease Model" |
| 1:45 pm - 1:50 pm | Discussion |
| 1:50 pm - 2:05 pm | Vanessa Zurli (University of Siena, Italy)
"Abnormal Arl8-Controlled Lysosomal Trafficking in Cytotoxic T Lymphocytes Underlies a Novel Immune Evasion Mechanism" |
| 2:05 pm - 2:10 pm | Discussion |
| 2:10 pm - 2:25 pm | Roberto Villasenor (Roche Innovation Center Basel, Switzerland)
"Increasing Blood-Brain Barrier Transcytosis by Regulating Intracellular Sorting to Lysosomes" |
| 2:25 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
