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Lysosomes and Endocytosis (GRS)
Gordon Research Seminar

Moving Endosomes from Basic Principles to Development and Disease

Dates

June 11-12, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Colin D.H. Ratcliffe & Olivia Majer

Meeting Description

The Gordon Research Seminar on Lysosomes and Endocytosis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to present recent findings and new approaches to studies of lysosome biology and endocytosis. Attendees perform cutting edge research on endocytosis and membrane trafficking in a variety of contexts, including molecular mechanisms of trafficking, sorting in the endo-lysosomal pathway, immunity, diabetes and cancer. The GRS will also hold an informal career-building panel where trainees will draw insight from leaders in the field.

Related Meeting

This GRS was held in conjunction with the "Lysosomes and Endocytosis" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: The Lysosome in Nutrient Sensing and Cellular Growth Control
Discussion Leaders: Ralf Leonhardt (Yale University School of Medicine, USA) and Peace Atakpa (University of Cambridge, United Kingdom)
3:45 pm - 4:15 pmRoberto Zoncu (University of California, Berkeley, USA)
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBasic Principles of the Endo-Lysosomal System
Discussion Leaders: Gillian Griffiths (Cambridge Institute for Medical Research, United Kingdom) and Tess Shideler (University of New Mexico, USA)
7:30 pm - 7:45 pmZachary Weinberg (Carnegie Mellon University, USA)
"Clathrin-Coated Pit Lifetimes Regulate Discrete Phases in GPCR Signaling"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmKelsie Eichel (University of California, San Francisco, USA)
"Mechanism and Signaling Consequences of Independent β-Arrestin and Receptor Trafficking"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmDanielle Johnson (Hospital for Sick Children, Canada)
"Not All Lysosomes Are Created Equal"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmCarlos Guardia (National Institutes of Health, USA)
"Coupling to Different Kinesin Motors Directs Regional Movement of Lysosomes Along Distinct Microtubule Tracks"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmThomas McWilliams (University of Dundee, United Kingdom)
"Mito-QC Illuminates Lysosomal Turnover of Mitochondria In Vivo"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmSrigokul Upadhyayula (Harvard Medical School, USA)
"Cellular Dynamics Imaged in Real Time and in 3D Using Lattice Light-Sheet Microscopy"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amInter-Organelle Contacts and Vesicular Sorting
Discussion Leaders: Lois Weisman (University of Michigan, USA), Icten Meras (McGill University, Canada) and Olivia Majer (University of California, Berkeley, USA)
9:00 am - 9:15 amEwan MacDonald (University of Liverpool, United Kingdom)
"Actin Mediated Receptor Recycling and Ubiquitin Mediated Receptor Degradation Are Functionally Coupled and Dynamically Opposed at the Endosome"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amFrances Tilley (University of Bristol, United Kingdom)
"Polycystin-2 Trafficking: A Role for Retromer"
9:35 am - 9:40 amDiscussion
9:40 am - 10:00 amGeneral Discussion
Mentorship Component: Career Panel
10:00 am - 11:00 amPanel Discussion
"Building Your Career"
  • Gillian Griffiths (Cambridge Institute for Medical Research, United Kingdom)
  • Roberto Weigert (National Cancer Institute, NIH, USA)
  • Lois Weisman (University of Michigan, USA)
  • Roberto Zoncu (University of California, Berkeley, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMembrane Trafficking in Health and Disease
Discussion Leaders: Roberto Weigert (National Cancer Institute, NIH, USA) and Debrup Sengupta (Yale School of Medicine, USA)
1:30 pm - 1:45 pmMaria Bagh (National Institute of Child Health and Human Development, NIH, USA)
"Defining Lysosomal Acidification Defect in a Mouse Model of a Neurodegenerative Lysosomal Storage Disease Model"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmVanessa Zurli (University of Siena, Italy)
"Abnormal Arl8-Controlled Lysosomal Trafficking in Cytotoxic T Lymphocytes Underlies a Novel Immune Evasion Mechanism"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmRoberto Villasenor (Roche Innovation Center Basel, Switzerland)
"Increasing Blood-Brain Barrier Transcytosis by Regulating Intracellular Sorting to Lysosomes"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13CA206290-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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