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NOX Family NADPH Oxidases (GRS)
Gordon Research Seminar

NOX Biology: From Mechanistic Insights Toward Functional Understanding

Dates

June 4-5, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Adam A. Nabeebaccus & Leonardo Y. Tanaka

Meeting Description

The Gordon Research Seminar on NOX Family NADPH Oxidases is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this year's meeting is to explore structure-function correlations in Nox biology. We plan to cover structural insights and their functional roles from the single cell to the complex organism, ultimately gaining knowledge of Nox in a wide variety of physiological and pathological situations. A highlight of this meeting is our strong focus on mentorship, which will pervade the entire program. The program will consist of scientific sessions selected from submitted abstracts for oral presentation, poster sessions and small-group workshops with our mentors, chosen specifically for their expertise at the forefront of the Nox field and their approachable manner. Thus we welcome graduate students and post-docs to submit an abstract and join in this highly interactive and cutting-edge forum.

Related Meeting

This GRS was held in conjunction with the "NOX Family NADPH Oxidases" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmBasics of Nox Family Biology: Structural Insights and Regulatory Mechanisms/Advances in NADPH Oxidase-Associated Proteins
Discussion Leaders: Hitesh Peshavariya (University of Melbourne, Australia) and William Nauseef (University of Iowa, USA)
3:45 pm - 3:50 pmIntroduction by Discussion Leader
3:50 pm - 4:05 pmDavid Heppner (University of Vermont, USA)
"Concerted Roles of DUOX1 and NOX2 in Redox Regulation of Epidermal Growth Factor Receptor Signaling"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmArturo Simoni (Universidad Autónoma Metropolitana, Mexico)
"Hepatocyte Growth Factor Regulates p22 Phox Through Transcriptional and Post-Translational Mechanisms"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFunctional Roles of Nox: From the Single Cell to the Complex Organism
Discussion Leaders: Siobhan Craige (University of Massachusetts Medical School, USA) and Ulla Knaus (Conway Institute, University College Dublin, Ireland)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmJacek Zielonka (Medical College of Wisconsin, USA)
"Superoxide and Hydrogen Peroxide Detection in Biological Systems: From Theory to Practice"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:05 pmIntroduction by Discussion Leader
8:05 pm - 8:20 pmAna Caroline Gandara (Instituto de Bioquímica Médica Leopoldo de Meis, Brazil)
"NOXm Is Not Restricted to Hematophagous Diptera: A Thorough Characterization of NOXm in Arthropods"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmTiphany De Bessa (Heart Institute of the University of São Paulo, Brazil)
"Ras Overactivation as a Potential Mechanism for Disrupted Protein Disulfide Isomerase/NADPH Oxidases Interaction"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmNaomi Boisvert (University of Ottawa, Canada)
"TRPC5 Is Required for NADPH Oxidase 5 Activity in Podocytes"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAslihan Terzi (Purdue University, USA)
"Generation of Zebrafish Lines with Mutations in Individual NADPH Oxidase Isoforms Using CRISPR/Cas9 Genome Editing"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amExploiting Nox Effects: Signalling Pathways, Inhibition, and Therapeutic Applications
Discussion Leaders: Leonardo Tanaka (Heart Institute of the University of São Paulo, Brazil) and Rhian Touyz (University of Glasgow, United Kingdom)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amMatteo Beretta (King's College Hospital, United Kingdom)
"HyPer Probes: A Powerful Tool for Specific Localization of H2O2 in Living Cells"
9:25 am - 9:30 amDiscussion
9:30 am - 9:35 amIntroduction by Discussion Leader
9:35 am - 9:50 amKaramatullah Danyal (University of Vermont, USA)
"Role of Dual Oxidase1 in Regulation of Mitochondrial ROS Production for Wound Repair in Lung Epithelium"
9:50 am - 9:55 amDiscussion
9:55 am - 10:10 amSharon O'Neill (University College Dublin, Ireland)
"Monitoring Conformational Dynamics of NADPH Oxidase Dimerization as a Novel Tool for Architecture-Based Screening"
10:10 am - 10:15 amDiscussion
10:15 am - 10:30 amCarmen Veith (Maastricht University, The Netherlands)
"NADPH Oxidases Induce Oxidative Damage in an In Vitro Model of Pulmonary Fibrosis"
10:30 am - 10:35 amDiscussion
10:35 am - 10:50 amMoritz Schnelle (King's College London, United Kingdom)
"NADPH Oxidase-4 Mediates Cardiac Adaptation to Volume Overload"
10:50 am - 10:55 amDiscussion
10:55 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Panel and Workshop Discussions
Discussion Leaders: Hitesh Peshavariya (University of Melbourne, Australia) and Siobhan Craige (University of Massachusetts Medical School, USA)
1:30 pm - 2:30 pmPanel Discussion
"NOX-ROS Where, When and How; Targeting NOX Going from Inhibitors to Therapies; A Career in the NOX Field"
  • Ulla Knaus (Conway Institute, University College Dublin, Ireland)
  • Francisco Laurindo (Heart Institute of the University of São Paulo, Brazil)
  • William Nauseef (University of Iowa, USA)
  • Rhian Touyz (University of Glasgow, United Kingdom)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible in part by 1 R13 AI124455-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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