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Phosphorylation & G-Protein Mediated Signaling Networks (GRS)
Gordon Research Seminar

Emerging Advances in Signaling Downstream of GPCRs and Kinases from Basic Mechanisms to Human Disease

Dates

June 4-5, 2016

Location

University of New England
Biddeford, ME

Organizers

Chairs:
Tanya Baldwin & Randi Fitzgibbon

Meeting Description

The Gordon Research Seminar on Phosphorylation and G-Protein Mediated Signaling Networks is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2016 GRS will utilize this unique platform to delve into the exciting advancements being made in G protein, kinase, and phosphatase signaling. The meeting will emphasize novel and mechanistic approaches to the development of innovative therapeutics and the elucidation of normal and aberrant signaling in human disease. This relaxed environment brings together young scientists providing the opportunity to establish collaborations and be exposed to the most recent advances in the field. The GRS will take place just prior to the Phosphorylation and G-Protein Mediated Signaling Gordon Research Conference.

Related Meeting

This GRS was held in conjunction with the "Phosphorylation & G-Protein Mediated Signaling Networks" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Fatty Acyl Tales of G-Protein Signaling
Discussion Leaders: Tanya Baldwin (University of Texas Health Science Center at Houston, USA) and Randi Fitzgibbon (University of Texas Graduate School of Biomedical Sciences at Houston, USA)
3:45 pm - 4:15 pmMaurine Linder (Cornell University, USA)
"Fatty Acyl Tales of G-Protein Signaling"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSignaling Networks in Times of Stress
Discussion Leaders: Jack Cook (Pfizer, USA) and Ruojing Li (Johns Hopkins School of Medicine, USA)
7:30 pm - 7:50 pmCesare Orlandi (The Scripps Research Institute, USA)
"The Orphan Receptor GPR158 Is a Component of RGS Complex with Key Roles in Mood Regulation via Controlling cAMP Signaling in Prefrontal Cortex"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmQunxiang Ong (Stanford University, USA)
"Optogenetic Modulation of Raf and AKT Activity in Protecting PC12 Cells Against Oxidative Stress"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmCraig Nash (University of Rochester, USA)
"Differential Compartmentalization of cAMP Is Required for Stimulation and Inhibition of Perinuclear Phospholipase Ce, Subsequent Phosphatidylinositol 4-Phosphate Hydrolysis and Cardiac Hypertrophy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmVassiliki Mitsi (Icahn School of Medicine at Mount Sinai, USA)
"RGS4 Is a Crucial Component of Stress, Depression and Fast-Acting Antidepressant Action"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amAdvances in Signaling Mechanisms
Discussion Leaders: Angeline Lyon (Purdue University, USA) and Jeffrey Liu (Max Planck Institute of Biochemistry, Germany)
9:00 am - 9:20 amKelsey Maxwell (McGovern Medical School, University of Texas Health Science Center, USA)
"Selective Lipid Sorting Regulates Rac1 Function"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJennifer Cash (University of Michigan, USA)
"Structural and Functional Characterization of Metastatic RhoGeF P-Prex1 and Its Regulation by PtdIns(3,4,5)P3: Towards Inhibitory Small Molecule Development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAndre Lazar (University of California, San Francisco, USA)
"Regulation of Adenylyl Cyclase by Isoform-Specific Endocytosis"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amRuth Sommese (University of Minnesota, Twin Cities, USA)
"Tuning the Substrate-Kinase Interaction in PKCalpha"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Development Panel
Our meeting will conclude with a panel discussion revolving around Career Development. The panel will be comprised of our keynote speaker and representatives of non-academic careers.
Discussion Leaders: Jesi Lee Anne To (University of Rochester, USA) and Levi McClelland (University of Montana, USA)
1:30 pm - 2:30 pmPanel Discussion
"Insights into Scientific Careers - Fireside Chats with Leaders in Industry and Academia"
  • Maurine Linder (Cornell University, USA)
  • Angeline Lyon (Purdue University, USA)
  • Jack Cook (Pfizer, USA)
  • Carmen Dessauer (McGovern Medical School, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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