The Gordon Research Seminar on Protein Processing, Trafficking and Secretion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present, grow their professional network and exchange new data and cutting edge ideas in the field with their peers.
This meeting will focus on the multiple molecular mechanisms affecting protein sorting as well as post-translational modifications taking place along the secretory pathways from the nascent polypeptides to their terminating degradation, including their shuttling in intracellular compartments. Together with their physiological roles, these events will also be addressed on the pathological point of view since the deregulation of protein processing, folding and aggregation are also at the basis of diseases (e.g. Alzheimer's; hypercholesterolemia; neoplasia; viral and bacterial infections; and many others).
emphasize two important training features of the Program. First, in her keynote lecture, Dr. Klaudia Brix will
aim at unifying the various fields represented in the audience around the GRS
central question: "Understanding Protein Fates in Health and Diseases". Second, the 2016 GRS will include a completely novel
session entitled "Cutting Edge Methodologies in the Study of Protein Processing, Trafficking and Secretion" featuring two technology-oriented discussions. This session aims at training the attendees in the use of recently developed and impactful methods in the field to
study questions relevant to their on-going research in novel ways.
This GRS was held in conjunction with the "Protein Processing, Trafficking & Secretion" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Keynote Session: Processing Enzymes of Endo-Lysosomes - Myths, Advances, and Challenges|
|Discussion Leader: Frederic Couture (Université de Sherbrooke, Canada)|
|3:45 pm - 4:20 pm||Klaudia Brix (Jacobs University Bremen, Germany)|
"Processing Enzymes of Endo-Lysosomes - Myths, Advances, and Challenges"
|4:20 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Exploring the Basis of Trafficking and
|Discussion Leader: Linda van Keimpema (VU University Amsterdam, The Netherlands)|
|7:30 pm - 7:45 pm||Xingmin Zhang (University of Wisconsin-Madison, USA)|
"A Novel Munc13/CAPS Family Protein, BAIAP3, Is Required for Regulated Exocytosis in Neuroendocrine Cells"
|7:45 pm - 7:50 pm||Discussion|
|7:50 pm - 8:05 pm||Jessica Blackburn (University of Arkansas for Medical Sciences, USA)|
"Deletion of the Conserved Oligomeric Golgi Subunits Impairs Protein Trafficking and Glycosylation and Results in Dramatically Enlarged Endosomal/Lysosomal Compartments"
|8:05 pm - 8:10 pm||Discussion|
|8:10 pm - 8:25 pm||Antonio Santos (Centre for Genomic Regulation (CRG), Spain)|
"The Novel Chimeric Protein Mia2/cTAGE5 Loads Pre-Chylomicrons/VLDLs at Endoplasmic Reticulum Exit Sites for Their Export"
|8:25 pm - 8:30 pm||Discussion|
|8:30 pm - 8:45 pm||Alejandra Canales (University of Wisconsin-Madison, USA)|
"Using Toxoplasma gondii as a Model Organism to Study Protein Trafficking"
|8:45 pm - 8:50 pm||Discussion|
|8:50 pm - 9:05 pm||Javier Emperador Melero (VU University Amsterdam, The Netherlands)|
"Development of Dense Core Vesicle Fusion and Trafficking in Human iPSC-Derived Neurons"
|9:05 pm - 9:10 pm||Discussion|
|9:10 pm - 9:30 pm||General Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||Understanding Protein Processing and
|Discussion Leader: Stephanie Duval (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada)|
|9:00 am - 9:15 am||Swe-Htet Naing (Georgia Institute of Technology, USA)|
"Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:35 am||Amro Mohammad (Goodman Cancer Research Centre, McGill University, Canada)|
"The PTEN/PACE4/[p]RR/mTORC1 Axis in Prostate Cancer Cell Progression"
|9:35 am - 9:40 am||Discussion|
|9:40 am - 9:55 am||Bruno Ramos-Molina (KU Leuven, Belgium)|
"Inactivation of Furin in β Cells Results in β Cell Dysfunction and Activation of the ATF4 Pathway"
|9:55 am - 10:00 am||Discussion|
|10:00 am - 10:15 am||James Checco (University of Illinois at Urbana-Champaign, USA)|
"Exploring the Signaling Pathways of D-Amino Acid-Containing Neuropeptides"
|10:15 am - 10:20 am||Discussion|
|10:20 am - 10:35 am||Lorelei Durand (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada)|
"The Proprotein Convertase PC7: Regulation of Its Enzymatic Activity and Trafficking Through the Conventional Secretory Pathway"
|10:35 am - 10:40 am||Discussion|
|10:40 am - 11:00 am||General Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: Cutting Edge Methodologies in the Study of Protein Processing, Trafficking and Secretion|
|This technology-oriented talk and discussion will help train attendees in the use of recently
developed and impactful methods to study questions relevant to their on-going
research in novel ways.|
|Discussion Leader: Anna Jansen (University of Copenhagen, Denmark)|
|1:30 pm - 1:50 pm||Lloyd Fricker (Albert Einstein College of Medicine, USA)|
"Developing New Methodologies to Study Protein Processing"
|1:50 pm - 2:00 pm||Discussion|
|2:00 pm - 2:20 pm||Galia Blum (Hebrew University of Jerusalem, Israel)|
"How to Design and Generate Molecular Probes for Studying the Trafficking and Activity of Proteases"
|2:20 pm - 2:30 pm||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS096766. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
This material is based upon work supported by the Air Force Office of Scientific Research under
award number FA9550-16-1-0123. Any opinions, finding, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the United States Air Force.