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Protein Processing, Trafficking and Secretion (GRS)
Gordon Research Seminar

At the Cutting Edge of Understanding Protein Fates in Health and Diseases

Dates

July 23-24, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chairs:
Frederic Couture & Anna M. Jansen

Meeting Description

The Gordon Research Seminar on Protein Processing, Trafficking and Secretion is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present, grow their professional network and exchange new data and cutting edge ideas in the field with their peers.

This meeting will focus on the multiple molecular mechanisms affecting protein sorting as well as post-translational modifications taking place along the secretory pathways from the nascent polypeptides to their terminating degradation, including their shuttling in intracellular compartments. Together with their physiological roles, these events will also be addressed on the pathological point of view since the deregulation of protein processing, folding and aggregation are also at the basis of diseases (e.g. Alzheimer's; hypercholesterolemia; neoplasia; viral and bacterial infections; and many others).

We emphasize two important training features of the Program. First, in her keynote lecture, Dr. Klaudia Brix will aim at unifying the various fields represented in the audience around the GRS central question: "Understanding Protein Fates in Health and Diseases". Second, the 2016 GRS will include a completely novel session entitled "Cutting Edge Methodologies in the Study of Protein Processing, Trafficking and Secretion" featuring two technology-oriented discussions. This session aims at training the attendees in the use of recently developed and impactful methods in the field to study questions relevant to their on-going research in novel ways.

Related Meeting

This GRS was held in conjunction with the "Protein Processing, Trafficking and Secretion" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Processing Enzymes of Endo-Lysosomes - Myths, Advances, and Challenges
Discussion Leader: Frederic Couture (Université de Sherbrooke, Canada)
3:45 pm - 4:20 pmKlaudia Brix (Jacobs University Bremen, Germany)
"Processing Enzymes of Endo-Lysosomes - Myths, Advances, and Challenges"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmExploring the Basis of Trafficking and Secretion
Discussion Leader: Linda van Keimpema (VU University Amsterdam, The Netherlands)
7:30 pm - 7:45 pmXingmin Zhang (University of Wisconsin-Madison, USA)
"A Novel Munc13/CAPS Family Protein, BAIAP3, Is Required for Regulated Exocytosis in Neuroendocrine Cells"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmJessica Blackburn (University of Arkansas for Medical Sciences, USA)
"Deletion of the Conserved Oligomeric Golgi Subunits Impairs Protein Trafficking and Glycosylation and Results in Dramatically Enlarged Endosomal/Lysosomal Compartments"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAntonio Santos (Centre for Genomic Regulation (CRG), Spain)
"The Novel Chimeric Protein Mia2/cTAGE5 Loads Pre-Chylomicrons/VLDLs at Endoplasmic Reticulum Exit Sites for Their Export"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmAlejandra Canales (University of Wisconsin-Madison, USA)
"Using Toxoplasma gondii as a Model Organism to Study Protein Trafficking"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJavier Emperador Melero (VU University Amsterdam, The Netherlands)
"Development of Dense Core Vesicle Fusion and Trafficking in Human iPSC-Derived Neurons"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amUnderstanding Protein Processing and Post-Translational Modifications
Discussion Leader: Stephanie Duval (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada)
9:00 am - 9:15 amSwe-Htet Naing (Georgia Institute of Technology, USA)
"Catalytic Properties of Intramembrane Aspartyl Protease Substrate Hydrolysis Evaluated Using a FRET Peptide Cleavage Assay"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAmro Mohammad (Goodman Cancer Research Centre, McGill University, Canada)
"The PTEN/PACE4/[p]RR/mTORC1 Axis in Prostate Cancer Cell Progression"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amBruno Ramos-Molina (KU Leuven, Belgium)
"Inactivation of Furin in β Cells Results in β Cell Dysfunction and Activation of the ATF4 Pathway"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amJames Checco (University of Illinois at Urbana-Champaign, USA)
"Exploring the Signaling Pathways of D-Amino Acid-Containing Neuropeptides"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amLorelei Durand (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada)
"The Proprotein Convertase PC7: Regulation of Its Enzymatic Activity and Trafficking Through the Conventional Secretory Pathway"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Cutting Edge Methodologies in the Study of Protein Processing, Trafficking and Secretion
This technology-oriented talk and discussion will help train attendees in the use of recently developed and impactful methods to study questions relevant to their on-going research in novel ways.
Discussion Leader: Anna Jansen (University of Copenhagen, Denmark)
1:30 pm - 1:50 pmLloyd Fricker (Albert Einstein College of Medicine, USA)
"Developing New Methodologies to Study Protein Processing"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmGalia Blum (Hebrew University of Jerusalem, Israel)
"How to Design and Generate Molecular Probes for Studying the Trafficking and Activity of Proteases"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS096766. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

This material is based upon work supported by the Air Force Office of Scientific Research under award number FA9550-16-1-0123. Any opinions, finding, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the United States Air Force.
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