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Proteoglycans (GRS)
Gordon Research Seminar

Proteoglycans as Functional Regulators of Development and Disease

Dates

July 9-10, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Tabea Dierker

Meeting Description

The Gordon Research Seminar on Proteoglycans is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting will be on the functional aspects of proteoglycans and their regulatory roles in cellular processes. The meeting will address basic research questions about biosynthesis and structure of proteoglycans, their effect on signaling and other processes in development and disease, as well as therapeutic and translational applications. In addition, there will be a mentoring session on scientific work and publishing, during which participants can get advice and discuss their questions with Professor Jeff Esko (UC San Diego), one of the leading scientists in the Proteoglycan field. The meeting will conclude with a short talk by 2013 Nobel Laureate Randy Schekman (UC Berkeley) on "How to Publish Science with an Impact".

The GRS attendees are also encouraged to apply to attend the associated Proteoglycans GRC meeting which will link them to the wider research community. Active participation by young scientists in the Proteoglycans GRC meeting is strongly promoted by the meeting Chairs.

Related Meeting

This GRS was held in conjunction with the "Proteoglycans" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Small Proteoglycans
Discussion Leaders: Anthony Day (University of Manchester, United Kingdom) and Velina Bachvarova (University of Duisburg-Essen, Germany)
3:45 pm - 4:15 pmMarian Young (National Institutes of Health, USA)
"Small Proteoglycans: Versatile Regulators of Bone Formation, Function and Repair"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Good and Bad of Proteoglycans: Effects in Developmental Processes and Disease Progression
Discussion Leaders: Shyam Bandari (University of Alabama at Birmingham, USA) and Rogier Reijmers (VU University Medical Center Amsterdam, The Netherlands)
7:30 pm - 7:45 pmHannah Clarke (University of Liverpool, United Kingdom)
"Altered Heparan Sulfate in Ageing and Dementia: A Potential Axis for the Dysregulation of BACE-1 in Alzheimer's Disease"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmVivien Coulson-Thomas (University of Houston, USA)
"Heparan Sulfate Regulates Hair Follicle Development"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmLaura Ferreras (Institute of Cellular Medicine, Newcastle University, United Kingdom)
"Investigating the Role of Heparan Sulfate 3-O Sulfotransferases in Renal Fibrosis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmFengying Tang (University of New South Wales, Australia)
"The Roles of CSPG4 and Perlecan in Cancer, Potential Targets for Drug Therapy"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmYeojung Kim (Cleveland Clinic Lerner Research Institute, USA)
"Hyaluronan 35 kDa Treatment Induces Epithelial Tight Junction Protein ZO-1 In Vivo and May Be a Mechanism of Protection in Mice from Citrobacter Infection"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAravind Sivakumar (Cornell University, USA)
"Hyaluronan Synthesis Provides a Mechanism for Asymmetric Gut and Vascular Morphogenesis"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amHow Proteoglycans Affect Cell Signaling / Structure-Function Correlations in the Extracellular Matrix
Discussion Leaders: Andrew Hamilton (Uppsala University, Sweden) and Sarah Taylor (University of Liverpool, United Kingdom)
9:00 am - 9:15 amOleksandr Nychyk (UCL Institute of Child Health, University College London, United Kingdom)
"The Role of Proteoglycans in the Initiation of Neural Tube Closure"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amSarvenaz Sarabipour (Johns Hopkins University, USA)
"HSPG Allosterically Regulate FGF-FGFR Interactions"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amRachel Ghadiali (University of Liverpool, United Kingdom)
"Dynamic Changes in Heparan Sulfate During Muscle Differentiation and Ageing Are Associated with Regulation of Myoblast Cell Fate and FGF2 Signalling"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amNehru Viji Sankaranarayanan (Virginia Commonwealth University, USA)
"Computational Identification of Preferred Molecular Targets of Non-Saccharide Glycosaminoglycan Mimetics that Selectively Inhibit Cancer Stem Cell Growth"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJelena Rnjak-Kovacina (University of New South Wales, Australia)
"Biomimetic Approaches Toward Silk Biomaterial Vascularisation Using Perlecan"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amHeather Davies (CNRS, France)
"Cell Homing at the Blood Vessel Wall – Biomechanical vs Biochemical Controls"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: From Bench Work to High Impact Publishing
Discussion Leaders: Rachel Ghadiali (University of Liverpool, United Kingdom) and Aaron Petrey (Cleveland Clinic, USA)
1:30 pm - 1:50 pmJeffrey Esko (University of California, San Diego, USA)
"How to Be Mensch at the Bench"
1:50 pm - 2:00 pmDiscussion
2:00 pm - 2:20 pmRandy Schekman (University of California, Berkeley, USA)
"How to Publish Science with Impact"
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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