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Proteolytic Enzymes & Their Inhibitors (GRS)
Gordon Research Seminar

Understanding the Role of Proteolysis in Homeostasis and Disease

Dates

June 25-26, 2016

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Anthony J. O'Donoghue & Leila Akkari

Meeting Description

The Gordon Research Seminar on Proteolytic Enzymes and Their Inhibitors is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight recent developments for the role of proteolytic enzymes and inhibitors in complex biological processes. In healthy cells and tissues, proteolysis is tightly controlled, however dysregulated proteolysis occurs in cancer, infectious disease and many immune-, neurodegenerative- and cardiovascular- disorders. Therefore it is imperative to understand the role that these enzymes and their inhibitors play in modulating a disease.

Related Meeting

This GRS was held in conjunction with the "Proteolytic Enzymes & Their Inhibitors" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmNovel Approaches to Detecting and Altering Proteases
Discussion Leader: Antoine Dufour (University of British Columbia, Canada)
3:15 pm - 3:25 pmYael Bennun (Institute for Drug Research, The Hebrew University of Jerusalem, Israel)
"Conversion of Quenched Cathepsin Activity Based Probes to Theranostics Tools"
3:25 pm - 3:30 pmDiscussion
3:30 pm - 3:40 pmMichael Lane (University of Minnesota, USA)
"Developing Comprehensive Specificity Profiling of Promiscuous Proteases"
3:40 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmJaideep Dudani (Massachusetts Institute of Technology, USA)
"Nanosystems to Profile Disease-Associated Proteases In Vivo"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Discovery and Development of a Protease Inhibitor for Chagas Disease / From Simple Viruses to Complex Parasites: Targeting Proteases in Infectious Disease
Discussion Leader: Laura Edgington-Mitchell (Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
5:30 pm - 6:05 pmJames McKerrow (University of California, San Diego, USA)
"Discovery and Development of a Protease Inhibitor for Chagas Disease"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmNyssa Drinkwater (Monash University, Australia)
"Dual Inhibition of the M1 and M17 Aminopeptidases"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmAshley Matthew (University of Massachuetts Medical School, USA)
"Structure-Based Design of Robust Cross-Genotypic NS3/4A Protease Inhibitors that Avoid Resistance"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmMichael Winter (University of California, San Francisco, USA)
"Global Identification of Biofilm-Specific Proteolysis in Candida albicans"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmHao Li (Agency for Science, Technology and Research (A*STAR), Singapore)
"Identification and Characterization of Novel Microbial Secreted Proteases in Human Skin Disease Pathogenesis"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amRegulation of Inflammation, Immunity and Cancer by Proteases
Discussion Leader: Jaideep Dudani (Massachusetts Institute of Technology, USA)
9:00 am - 9:15 amVishnu Mohan (Weizmann Institute of Science, Israel)
"Novel Antibody Targeting MMP-7 Shows Therapeutic Potential Against Pancreatic Cancer"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAntoine Dufour (University of British Columbia, Canada)
"Multi-Omics Analysis of Macrophage Polarization"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amStephanie Ketterer (Albert Ludwigs University of Freiburg, Germany)
"Cell Type-Specific Deletion of Cathepsin D in Murine Breast Cancer"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amDarya Tsvirkun (The Hebrew University of Jerusalem, Israel)
"Molecular Imaging of Cancer Using Cathepsin Targeted CT Contrast Agents"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amMaureen Hill (University of Massachusetts Amherst, USA)
"Engineering Caspases with Altered Specificities"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amFrederic Couture (Université de Sherbrooke, Canada)
"Secretome Proteomic Analysis Identifies Substrates of the Proprotein Convertase PACE4 in Prostate Cancer"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Anthony O'Donoghue (University of California, San Diego, USA)
1:30 pm - 2:30 pmPanel Discussion
"Can You Be a Successful Scientist While Maintaining a Healthy Work-Life Balance?"
  • James McKerrow (University of California, San Diego, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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