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Cell Contact & Adhesion (GRS)
Gordon Research Seminar

How Cells Stick, Slide, and Impact Our Lives

Dates

June 17-18, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Torey Arnold

Meeting Description

The Gordon Research Seminar on Cell Contact and Adhesion is a forum for graduate students and postdocs to share and discuss cutting edge research in a constructive environment. The focus of this meeting will be to understand cell-cell and cell-surface interaction from the scale of amino acids to whole tissues and will cover disciplines ranging from biophysics to developmental biology.

Related Meeting

This GRS was held in conjunction with the "Cell Contact & Adhesion" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmAdhesion and Disease
Discussion Leader: Matthew Kutys (Boston University, USA)
3:45 pm - 3:50 pmOpening Remarks
3:50 pm - 4:05 pmAmber Caldara (Emory University, USA)
"A Novel Desmoglein 1 Mutation Abrogates Lipid Raft Targeting and Causes SAM Syndrome"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmAdrian Luna (University of New Mexico Health Science Center, USA)
"The Interplay Between HPV Oncogene Expression and Contact Inhibition"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdhesion Mechanics
Discussion Leaders: Junior West (University of Toronto, Canada) and Henri Huppert (Institute of Medical Biology, A*STAR, Singapore / University of Manchester, United Kingdom)
7:30 pm - 7:45 pmSamantha Barrick (University of Illinois at Urbana-Champaign, USA)
"Salt Bridges Gate Alpha-Catenin Activation at Intercellular Junctions"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAnant Chopra (Boston University, USA)
"Force Generation via β-Muscle Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Focal Adhesions"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAnna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
"Developing a Desmoplakin Tension Sensor"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmKathryn Rosowski (ETH Zurich, Switzerland)
"Stiffening and Reinforcement of Adherent Fibroblasts During Stretch and Its Vinculin Dependence"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmZainab Rahil (University of Illiniois at Urbana-Champaign, USA)
"Mechanoselectivity: Cell's Guide to Force Transduction"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmCornelia Schwayer (IST Austria, Austria)
"Mechanochemical Feedback Loop Driving Epithelial Tissue Spreading During Zebrafish Development"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMolecules to Organisms
Discussion Leaders: Anant Chopra (Boston University, USA) and Anna-Lena Cost (Max Planck Institute of Biochemistry, Germany)
9:00 am - 9:15 amShafali Gupta (Institute of Molecular Biosciences, University of Queensland, Australia)
"Active Response of E-Cadherin Junctions During Collective Cell Migration"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amJunior West (University of Toronto, Canada)
"An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation Under Stress"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amPrateek Arora (Tata Institute of Fundamental Research, Mumbai, India)
"Reciprocal Interactions Between aPKC and Lgl with E-Cadherin Establish a Mechanically Robust Bi-Layered Epidermis During Zebrafish Development"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amTeresa Bonello (University of North Carolina at Chapel Hill, USA)
"Defining the Network of Proteins Driving Apical-Basal Polarity Establishment in Early Drosophila Development"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amTony Tsai (Harvard Medical School, USA)
"Cracking the Adhesion Code Underlying Robust Pattern Formation in Zebrafish Spinal Cord"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amSarah Imtiaz (Max Planck Institute of Molecular Physiology, Germany)
"Studying the Formation and Function of Adhesion Sites by the Quantitative Multi-Parametric Analysis"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmRemodeling Adhesion
Discussion Leader: Torey Arnold (University of Michigan, USA)
1:30 pm - 1:45 pmSaranyaraajan Varadarajan (University of Michigan, USA)
"The Role of Calcium Influx in Remodeling of Epithelial Cell-Cell Junctions"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmHenri Huppert (Institute of Medical Biology, A*STAR, Singapore / University of Manchester, United Kingdom)
"Regulation of Desmosome Internalisation"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmMatthew Kutys (Boston University, USA)
"A Mechanosensitive Notch Complex Regulates Vascular Endothelial Junctions and Barrier Function"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13CA216892-01 from the National Cancer Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development . The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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