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Cellular & Molecular Mechanisms of Toxicity (GRS)
Gordon Research Seminar

Chemical-Microbiome Interactions in Toxicology

Dates

August 12-13, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chairs:
Alessandro Venosa & Karilyn E. Sant

Application Deadline

The application deadline for this meeting was July 15, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

Overview

The Gordon Research Seminar on Cellular and Molecular Mechanisms of Toxicity is a unique forum for graduate students, postdocs, and other early career scientists to present and exchange novel, cutting-edge ideas. The focus of this meeting is to provide young scientists and investigators with an inviting forum for the exchange and discussion of new/unpublished data on mechanistic toxicology. The GRS will highlight recent advancements in the field of microbiome analysis, aimed towards safety assessment and understanding mechanisms of toxicity. The GRS will include a scientific development session with panelists from industry, government, and academia in order to provide attendees with information regarding data rigor and reproducibility.

Attendees are expected to fully participate in the GRS and present original research, thus all applications must include an abstract. Young scientists are invited to present research on all areas of mechanistic toxicology including microbiome modeling, translational studies, computational toxicology, and more. The GRS will include approximately 8 graduate student/postdoc platform presentations, which the Chairs will select from the abstracts. All attendees are expected to present their original research by presenting a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above. All applicants are strongly encouraged to submit an application for the associated Gordon Research Conference from August 14-19, 2017.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by May 12, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Cellular & Molecular Mechanisms of Toxicity" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmEarly Life Exposure and Disease
Discussion Leaders: Alessandro Venosa (University of Pennsylvania, USA) and Thomas Gonzalez (University of Michigan, USA)
3:45 pm - 3:50 pmOpening Remarks
3:50 pm - 4:05 pmJorine Voss (University of Texas at Austin, USA)
"Exposure of Peripubertal Rats to Mono-(2-Ethylhexyl) Phthalate (MEHP) Leads to a Pro-Inflammatory Environment in the Testis with the Infiltration of Both Macrophages and Neutrophils"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmElizabeth Martin (University of North Carolina at Chapel Hill, USA)
"Sexual Epigenetic Dimorphism in the Human Placenta: Implications for Susceptibility to Stressors During the Prenatal Period"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMicrobiota and Development / Reproductive Toxicology
Discussion Leaders: Emma Bowers (Curriculum in Toxicology, University of North Carolina at Chapel Hill, USA) and Karilyn Sant (University of Massachusetts, USA)
7:30 pm - 7:55 pmStephanie Shore (Harvard T.H. Chan School of Public Health, USA)
"Obesity and Asthma: Microbiome-Metabolome Interactions"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmTamara Tal (U.S. Environmental Protection Agency, USA)
"Host-Associated Microbiota and Chemical Induced Developmental Toxicity"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDana Walsh (Mayo Clinic, USA)
"Metformin Protects Against Chemotherapy-Induced Loss of Gut Microbiota Diversity in Ovarian Cancer"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmAlisa Suen (National Institute of Environmental Health Sciences, NIH, USA)
"SIX1 Oncoprotein Is Necessary for Abnormal Uterine Basal Cell Development in Neonatally DES Exposed Mice"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLudwik Gorczyca (Rutgers University, USA)
"Role for Efflux Drug Transporters in Placental Cell Syncytialization"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amUncovering Mechanisms Governing Tissue Metabolic Programming / Toxicogenomics / Immunotoxicology
Discussion Leaders: Rosa Chan (University of California, San Francisco, USA), Suzanne Martos (Johns Hopkins University, USA) and John Szilagyi (Rutgers University, USA)
9:00 am - 9:15 amKatelyn Lavrich (University of North Carolina at Chapel Hill, USA)
"Air Pollutant 1,2-Naphthoquinone Inhibits Glycolysis Through Peroxide-Dependent Protein Inactivation in Human Bronchial Epithelial Cells"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amAnna Pfalzer (Vanderbilt University, USA)
"Alterations in Arginine, Cholesterol and Energy Metabolism Are Rescued with Manganese Exposure in a Mouse Model of Huntington's Disease"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amKari Neier (University of Michigan School of Public Health, USA)
"Altered Early Life Pancreatic Redox Environment as a Potential Mechanism Linking Perinatal Phthalate Exposures with Altered Metabolic Profile in Adulthood"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amEva Vitucci (University of North Carolina at Chapel Hill, USA)
"A Cellular Game of Telephone: Trans-Tissue Reprogramming of Responses to Toxic Stimuli"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amChristina Post (School of Medicine & Dentistry, University of Rochester Medical Center, USA)
"AHR Activation During Development Skews Antiviral CD8+ T Cells Toward Senescence and Exhaustion"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amThomas Hammond (University of Basel, Switzerland)
"Do Acyl Glucuronide Metabolites of Carboxylic Acid Drugs Have a Potential to Elicit Idiosyncratic Hypersensitivity?"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Data Rigor and Reproducibility: Considerations for Statistical Analysis, Transparency, and Management
Discussion Leader: Emily Martell (University of Rhode Island, USA)
1:30 pm - 1:40 pmShaun McCullough (U.S. Environmental Protection Agency, USA)
"Increasing Reproducibility Through Quality Experimental Design and Methodology"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmJason Richardson (Northeast Ohio Medical University, USA)
"Considerations for Interpretation and Reporting of Results"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmGlenn Begley (BioCurate Pty Ltd, Australia)
"The Current Problem with Rigor and Reproducibility"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmRadhika Dhingra (U.S. Environmental Protection Agency, USA)
"Statistical Analysis 'Good Practices' to Improve Data Rigor"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for the conference was made possible (in part) by 1 R13 ES 028073-01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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