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Glycobiology (GRS)
Gordon Research Seminar

Glycan Function and Structure in Development, Disease, and Host-Pathogen/Symbiont Interactions

Dates

March 18-19, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Melody (Mindy) Porterfield

Meeting Description

The Gordon Research Seminar on Glycobiology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to highlight recent progress on the contributions of viral, microbe, protozoan and metazoan model systems in understanding the function of glycosylation, as well as the roles of glycans, glycoproteins, and glycolipids in organismal development, mature tissue function, and the pathophysiology of glycan-related disorders. Interactions between host, microbes, and parasites will also be discussed. A mentored career development section will conclude the Seminar.

Related Meeting

This GRS was held in conjunction with the "Glycobiology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmGlycans in Development
Roles glycans, glycoproteins, and glycolipids play in organismal development will be presented.
Discussion Leader: Elsenoor Klaver (University of Georgia, USA)
3:45 pm - 3:55 pmSarah Konze (Hannover Medical School, Germany)
"Glycoproteomic Analysis of Human Pluripotent Stem Cells and Stem Cell-Derived Cardiomyocytes"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 4:10 pmNian Wu (Imperial College London, United Kingdom)
"Characterization of a Keratan Sulfate Antigen Expressed on Human-Induced Pluripotent Stem and Embryonic Stem Cells by Glycosaminoglycan Designer Microarrays"
4:10 pm - 4:15 pmDiscussion
4:15 pm - 4:25 pmBarbara Eckmair (University of Natural Resources and Life Sciences, Vienna, Austria)
"Analysis of Anionic N-Linked Glycans by MALDI-TOF Mass Spectrometry of Echinodermata Species"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGlycans in Disease
The roles of glycans, glycoproteins, and glycolipids in the pathophysiology of glycan-related disorders will be presented.
Discussion Leader: Nickita Mehta (Ragon Institute of MGH, Harvard and MIT, USA)
7:30 pm - 7:40 pmJesus Aguilar Diaz de Leon (Arizona State University, USA)
"Interleukin-6 Modulates Glycan Structure of Glycoproteins Secreted by Hepg2 Cells"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmGaurang Bhide (University of Illinois at Chicago, USA)
"Protein-Specific Polysialylation: Substrate Hierarchies and Inhibition"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmPanida Lertkiatmongkol (BloodCenter of Wisconsin, USA)
"Contribution of PECAM-1 Glycans to Endothelial Cell Barrier Function"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmDavid Nix (Complex Carbohydrate Research Center, University of Georgia, USA)
"Glycosylation and Innate Immunity in a Murine Model of Alzheimer's Disease"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmNithya Selvan (University of Georgia, USA)
"Understanding Causality of O-GlcNAc Transferase Mutations in X-Linked Intellectual Disability"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmMarek Whitehead (University of Zurich, Switzerland)
"The Kiss of Death by Artificial Sialylation of Mammalian Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmTimm Fiebig (Hannover Medical School, Germany)
"An Efficient Enzyme-Based Solid-Phase Synthesis of Meningococcal Capsular Oligosaccharides"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRoisin O'Flaherty (National Institute for Bioprocessing Research and Training (NIBRT), Ireland)
"High-Throughput Sequential Glycoprofiling of Six Abundant Glycoproteins Igg, Iga, Igm, Transferrin, Haptoglobin and Alpha-1-Antitrypsin in Ovarian Cancer"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amGlycans in Host-Pathogen/Symbiont Interactions
The roles of glycans, glycoproteins, and glycolipids in interactions between host, microbes, and parasites will be discussed.
Discussion Leader: Simone Kurz (Complex Carbohydrate Research Center, University of Georgia, USA)
9:00 am - 9:10 amAndreia Albuquerque (Hannover Medical School, Germany)
"Characterization of Apicomplexan Parasites C-Mannosyltransferases"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amJessica Bevan (Instituto de Medicina Molecular (IMM), University of Lisbon, Portugal)
"Development of Immobilized Affinity Based Probes for Selective Enrichment of Glycosyltransferases in Trypanosoma brucei"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amKaren Coss (King's College London, United Kingdom)
"Longitudinal Glycoprofiling of Gp120s in an HIV-1 Infected Patient"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amTamir Dingjan (Monash University, Australia)
"In Silico Exploration of Burkholderia Ambifaria Lectin Binding to Blood Group Determinants for the Discovery of Glycomimetic Inhibitors"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amFrancesca Martini (Malcisbo AG, Switzerland)
"N-Glycan Profiling of Dirofilaria Immitis: Revealing Potential Immunogenic Components of the Canine Heartworm"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amGisela Weiss (University of Zurich, Switzerland)
"Metabolic Incorporation of Azido Sugars in Commensal Gut Bacteria"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amJana Fuehring (Hannover Medical School, Germany)
"Understanding Catalytic and Allosteric Mechanisms in UDP-Glucose Pyrophosphorylases: Towards Utilizing Conserved Enzymes as Novel Drug Targets"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amElda Iljazi (University of Dundee, United Kingdom)
"Defining D-Arabinose Metabolism in Leishmania Major and Crithidia Fasciculata"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Timm Fiebig (Hannover Medical School, Germany)
1:30 pm - 1:35 pmIntroduction by Discussion Leader
1:35 pm - 2:25 pmPanel Discussion
"Career Mentoring"
  • Linda Baum (University of California, Los Angeles, USA)
  • Karen Colley (University of Illinois at Chicago, USA)
  • Jeffrey Esko (University of California, San Diego, USA)
2:25 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by DE026693-01 from the National Institute of Dental and Craniofacial Research. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Institute of Allergy and Infectious Diseases. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Heart, Lung, and Blood Institute. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Institute of Arthritis and Musculoskeletal and Skin Diseases. This award is co-funded by the National Institute of Dental and Craniofacial Research and the National Center for Advancing Translational Sciences, the National Institute of Child Health and Human Development, the National Cancer Institute, and the National Eye Institute.
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