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Immunology of Fungal Infections (GRS)
Gordon Research Seminar

Exploring the Hosts' Weaknesses: New Insights from Basic Mechanisms to Complex Host-Pathogen Interactions to Combat Fungal Infections

Dates

January 14-15, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Jessica Quintin & Jeanette Wagener

Meeting Description

Bringing together the future leaders with current senior scientists working at the forefront of innovative research in medical mycology and fungal immunology, the Gordon Research Seminar on Immunology of Fungal Infections is a uniquely designed opportunity for graduate students, post-docs and young faculty from around the globe to foster future networks, collaborations and exchange new data and cutting edge ideas.

Fungal diseases, caused by a variety of different fungal species infecting plants and vertebrates, are on the rise and pose a growing threat to global health and economy. In humans, fungal infections, caused by endogenous and environmental species, mainly occur in individuals with compromised immune status. Here, they can develop into life-threatening invasive infections with high mortality rate. The initial induction, the fine-tuning and the maintenance of a balanced immune response are key to the resolution of an infection. In this context, recent research has highlighted important aspects of fungal recognition by host cells, and the subsequent induction of innate and adaptive responses, but also fungal strategies to counteract this defence system. Moreover, additional features that modulate the hosts' defence, which include cell metabolism, nutritional immunity, innate imprinting and the influence of the host microbiota on host-pathogen interactions have risen. This Gordon Research Seminar will focus on these recent insights into the complex interplay between the host and pathogen. The program will discuss fundamental concepts and new advances in the field and will give a unique opportunity for young scientists to engage with the fungal immunology community.

Related Meeting

This GRS was held in conjunction with the "Immunology of Fungal Infections" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: From Commensalism to Pathogenicity: Interactions of Candida albicans with the Host
Discussion Leader: Neil Gow (University of Aberdeen, United Kingdom)
3:45 pm - 4:25 pmBernhard Hube (Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Germany)
"From Commensalism to Pathogenicity: Interactions of Candida albicans with the Host"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmReceptors, Effectors and Beyond
Discussion Leaders: George Deepe (University of Cincinnati College of Medicine, USA), Kirsten Nielsen (University of Minnesota, USA) and Robert Cramer (Dartmouth College, USA)
7:30 pm - 7:45 pmMargherita Bertuzzi (University of Manchester, United Kingdom)
"Outcomes of the Aspergillus fumigatus Host-Pathogen Interaction at the Alveolar Epithelial Interface"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmShreya Bhattacharya (Indiana University School of Medicine - Terre Haute, USA)
"Caspofungin Promotes Eosinophil and γδ T Cell-Dependent Pathology in Invasive Aspergillosis"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmNatalie Lyall (Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, United Kingdom)
"Hyphal Mediated Dysregulation of Phagosome Maturation Following Phagocytosis of Candida albicans by Macrophages"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmNatarajaswamy Kalleda (Wuerzburg University Hospital, Germany)
"Corticosteroids Impair Granulocyte Transfusion Therapy by Targeting NET Formation and Neutrophil Antifungal Functions via ROS/Dectin1 Pathways"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMark Stappers (University of Aberdeen, United Kingdom)
"Recognition of DHN-Melanin by the Novel C-Type Lectin, MelLec, Is Essential for Protective Immunity to Aspergillus fumigatus"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmMarc Swidergall (Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, USA)
"Host EphA2 Senses β-Glucan on Oral Epithelial Cells During Candida albicans Infection"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amThe Immunology Behind Susceptibility - Implications for New Therapeutic Strategies
Discussion Leaders: Sarah Gaffen (University of Pittsburgh School of Medicine, USA), Teresa Zelante (University of Perugia, Italy) and Adilia Warris (University of Aberdeen, United Kingdom)
9:00 am - 9:15 amMariam Garelnabi (University of Birmingham, United Kingdom)
"The Role of Host Variability in Determining Macrophage Responses to Cryptococcosis"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amNansalmaa Amarsaikhan (Indiana University School of Medicine - Terre Haute, USA)
"Role of the Metabolic Cytokine Adiponectin in Detrimental Antifungal Immunity"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amRebecca Drummond (National Institutes of Health, USA)
"A CARD9-CXCR2 Axis Controls Neutrophil Recruitment to the Fungal Infected Central Nervous System"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amMark Gresnigt (Radboud University Nijmegen Medical Centre, The Netherlands)
"The Mucorales Rhizopus oryzae Induces a Host Response Completely Distinct from Other Opportunistic Pathogenic Fungi"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amElisabeth Lowe (University of Newcastle, United Kingdom)
"Fungal Cell Wall Breakdown by Commensal Gut Bacteria"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amAkash Verma (University of Pittsburgh, USA)
"The Fungal Toxin Candidalysin Is a Feed-Forward Amplifier of Innate IL-17-Dependent Responses in Oral Candidiasis"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Next Generation Mentoring
Open discussion with leading scientists on career development and progression.
Discussion Leaders: Jessica Quintin (Institut Pasteur, France) and Jeanette Wagener (Aberdeen Fungal Group, University of Aberdeen, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"Career Development and Progression"
  • Robert Cramer (Dartmouth College, USA)
  • George Deepe (University of Cincinnati College of Medicine, USA)
  • Sarah Gaffen (University of Pittsburgh School of Medicine, USA)
  • Neil Gow (University of Aberdeen, United Kingdom)
  • Kirsten Nielsen (University of Minnesota, USA)
  • Adilia Warris (University of Aberdeen, United Kingdom)
  • Teresa Zelante (University of Perugia, Italy)
  • Bernhard Hube (Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Germany)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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