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Malaria (GRS)
Gordon Research Seminar

The Basic Science of Malaria: A Springboard for New Approaches to Control and Elimination

Dates

July 1-2, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Vanessa Zuzarte-Luis & Kristina S. Burrack

Meeting Description

The Gordon Research Seminar on Malaria is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

New tools and strategies are needed to accelerate progress toward malaria control and elimination. To successfully meet this challenge we need a clearer understanding of the complex interplay between the Plasmodium parasite, its mosquito vector and the vertebrate host it infects. The 2017 Malaria GRS will focus on the biology of Plasmodium infection at every stage of the parasite's life cycle. Organised in line with the Malaria GRC, that will host world leaders in the field of malaria, but also non-malaria scientists, this GRS will provide a unique informal forum for graduate students and postdocs to present and discuss their data side-by-side with senior scientists that are at the forefront of their research fields.

Related Meeting

This GRS was held in conjunction with the "Malaria" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmTechnology and Drug Development
Discussion Leaders: Debakshi Mullick (Weizmann Institute of Science, Israel) and Kristina Burrack (University of Minnesota, USA)
3:15 pm - 3:25 pmMaria Penzo (London School of Hygiene and Tropical Medicine, United Kingdom)
"High-Throughput Screening to Develop New Inhibitors Against the Plasmodium falciparum Cyclic GMP-Dependent Protein Kinase"
3:25 pm - 3:30 pmDiscussion
3:30 pm - 3:40 pmMaria Bernabeu (Center for Infectious Disease Research, USA)
"3D Brain Microvessel Models for the Study of Cerebral Malaria Pathogenesis"
3:40 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmThao-Thy Pham (Rega Institute for Medical Research, KU Leuven, Belgium)
"Improved Method for Quantification of Malaria Parasite Sequestration in Tissues"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmHost-Parasite Interactions
Discussion Leaders: Omar Janha (University of Glasgow, United Kingdom) and Peter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
5:30 pm - 5:40 pmDora Posfai (Duke University, USA)
"Aquaporin-3 an Essential Host Protein for the Development of Liver Stage Malaria"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmKatharine Collins (QIMR Berghofer Medical Research Institute, Australia)
"Human to Mosquito Transmission of Plasmodium falciparum and Plasmodium vivax During Controlled Human Malaria Infection"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmE. Nicole Arroyo (University of Washington, USA)
"The CD4+ T Cell Response to Murine Malaria Is Dominated by a Long-Lasting Tfh Phenotype"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:30 pmKatherine Cumnock (Stanford University, USA)
"Metabolically Identified Interventions Alter Malaria Severity and Outcome"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmPaulo Bettencourt (University of Oxford / The Jenner Institute, United Kingdom)
"Plasmodium falciparum NF135 Immunopeptidome in Humanized Mice"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:05 pmLila Farrington (University of California, San Francisco, USA)
"Frequent Malaria Drives the Up-Regulation of CD16 and Markers of Cytotoxicity on Vd2 T Cells"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:20 pmOmar Sheriff (Nanyang Technological University, Singapore)
"Elucidating Protein Interactions Responsible for Host Cell Modification in Plasmodium falciparum Infected RBCs"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amParasite Biology
Discussion Leaders: David Khoury (University of New South Wales, Australia) and Kirsten Hanson (University of Texas at San Antonio, USA)
9:00 am - 9:10 amAnna Barcons-Simon (Institut Pasteur, France)
"The Trans-Acting GC-Rich Non-Coding RNA Regulates Monoallelic var Gene Expression in Plasmodium falciparum"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amNanika Coetzee (University of Pretoria, South Africa)
"Exploiting the Epigenomic and Proteomic Complexity of Plasmodium falciparum Gametocytogenesis"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amMarta Walczak (Stanford University, USA)
"Atg8, How Plasmodium Borrows Autophagy Machinery for Apicoplast Biogenesis"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amHao Yang (Australian National University, Australia)
"Role of Human Hydroxymethylbilane Synthase (hHMBS) in the Plasmodium falciparum"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amKingsley Badu (Kwame Nkrumah University of Science and Technology, Ghana)
"Secreted Ookinete and Sporozoite Protein: A Potential Infectious Bite Marker for Tracking Variation in Malaria Transmission Intensity"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amAnush Chiappino-Pepe (Ecole Polytechnique Federale de Lausanne, Switzerland)
"Identifying and Targeting Key Cellular Mechanisms for Proliferation in Plasmodium Parasites: A Combined Experimental and Computational Strategy"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amHilde von Grüning (University of Pretoria, South Africa)
"Toward CRISPR-Cas9 Evaluation of Putative Cell Cycle Regulators of the Plasmodium falciparum Parasite"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amAna Sanchez-Azqueta (University of Glasgow, United Kingdom)
"Targeting Protein Kinases in Malaria - The Potential of Inhibition of PfCLK3"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMalaria Pathogenesis
Discussion Leaders: Leen Vandermosten (KU Leuven, Belgium) and Geoffrey Hart (University of Minnesota, USA)
1:30 pm - 1:40 pmPamela Odorizzi (University of California, San Francisco, USA)
"Investigating the Impact of In Utero Malaria Exposure on CD4+ T Cell Immunity in Infants"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmOlivia Swann (Centre for Immunity, Infection and Evolution, United Kingdom)
"Neighbouring Polymorphisms in Complement Receptor 1 (CR1) Have Opposing Associations with Cerebral Malaria in Two Discrete African Case-Control Studies"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmChristine Hopp (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Longitudinal Analysis of Plasmodium falciparum-Specific Atypical and Classical Memory B Cell Responses to Natural Malaria Infection in Children and Adults"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmSarah Boudova (University of Maryland School of Medicine, USA)
"Chronic Placental Malaria Alters Fetal Cytokine Profiles"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible [in part] by 1R13AI134001 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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