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Red Cells (GRS)
Gordon Research Seminar

Exploring Transcriptional, Metabolic and Structural Mechanisms in Red Cell Biology and Disease

Dates

July 15-16, 2017

Location

Salve Regina University
Newport, RI

Organizers

Chairs:
Marlies P. Rossmann & Daniel Hidalgo

Meeting Description

The Gordon Research Seminar on Red Cells is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas prior to the full Gordon Research Conference at the same venue.

The scientific focus of this meeting covers the entire spectrum of red cell biology, from the transcriptional regulation of erythropoiesis to the structure, metabolism and function of red cells, and red cell diseases. The Red Cells GRS gives attendees the chance to discuss both their current research and future career options with their peers and senior scientists in the field.

Related Meeting

This GRS was held in conjunction with the "Red Cells" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: About Stem Cells and Red Cells: Two Perspectives
Discussion Leader: Daniel Hidalgo (University of Massachusetts Medical School, USA)
3:45 pm - 4:05 pmJames Palis (University of Rochester Medical Center, USA)
"A Developmental Journey"
4:05 pm - 4:15 pmDiscussion
4:15 pm - 4:30 pmGeneral Discussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: About Stem Cells and Red Cells: Two Perspectives (continued) / Understanding Red Cell Formation from Different Angles
Discussion Leaders: Alyson Smith (The Scripps Research Institute, USA) and Sara El Hoss (Integrated Biology of the Red Cell, INSERM UMR_S1134 / Institut National de la Transfusion Sanguine, France)
7:30 pm - 7:50 pmElaine Dzierzak (The University of Edinburgh, United Kingdom)
"Crossing Borders of Professional, Personal and Stem Cell Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAnnamaria Aprile (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Italy)
"Beta-Thalassemia Beyond the Erythropoietic Defect: Impaired Self-Renewal of Hematopoietic Stem Cell Within an Altered Bone Marrow Niche"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmJayme Olsen (University of Rochester, USA)
"Bmi-1 Overexpression Increases Ex Vivo Self-Renewal of Human Erythroblasts"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmAishwarya Swaminathan (University of Massachusetts Medical School, USA)
"Analyzing the Effect of Acute Deletion of Tet2 and Tet3 Dioxygenases on Erythropoiesis"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSteven Heshusius (Sanquin, The Netherlands)
"Fetal Hemoglobin Expression in Adult Erythroid Cultures Is Repressed by Signaling Activated by CD14+ Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShuping Zhang (Massachusetts Institute of Technology, USA)
"Genome-Wide Heme and eIF2aP Regulated Gene Expression in Basophilic Erythroblasts"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAndra Dumitru (Université Catholique de Louvain, Belgium)
"Investigation at High-Resolution of Red Blood Cells Plasma Membrane Lipid Microdomains"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amTranscriptional and Epigenetic Regulation of Erythropoiesis / Mentorship Component: Career Panel
The career panel consists of a diverse group of panelists, covering the spectrum of academic science at different career stages, geographic locations and type of institutions as well as alternative careers in the life sciences. Each panelist will give a brief introduction about their career path followed by a Q&A session moderated by the GRS Conference Chairs.
Discussion Leaders: Alejandra Macias (Massachusetts Institute of Technology, USA), Christophe Lechauve (St. Jude Children's Research Hospital, USA) and Marlies Rossmann (Harvard University, USA)
9:00 am - 9:10 amElisabeth Heuston (National Human Genome Research Institute, NIH, USA)
"Erythropoiesis Requires Epigenetic and Transcriptional Reprogramming to Divert Hematopoietic Stem and Progenitor Cells from Pre-Primed Megakaryocytic Fate"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amAvik Choudhuri (Harvard University, USA)
"Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variants of Red Blood Cell Traits"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amKyle Hewitt (University of Wisconsin-Madison, USA)
"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amMary Lee (University of Michigan Medical School, USA)
"Murine Tr4 Haploinsufficiency Results in Defective Erythropoiesis"
9:55 am - 10:00 amDiscussion
10:00 am - 11:00 amPanel Discussion
"Career Development"
  • Terry Bishop (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
  • Elaine Dzierzak (The University of Edinburgh, United Kingdom)
  • James Palis (University of Rochester Medical Center, USA)
  • Jeff Shearstone (Syros Pharmaceuticals, USA)
  • Deborah Sweet (Cell Stem Cell, Cell Press, USA)
  • Mitchell Weiss (St. Jude Children's Research Hospital, USA)
  • Jian Xu (University of Texas Southwestern Medical Center, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmRed Cell Disorders and Therapies
Discussion Leaders: Yuanting Chen (Pennsylvania State University, USA) and Giulia Pavani (Genethon, France)
1:30 pm - 1:40 pmChang Liao (Pennsylvania State University, USA)
"Selenoproteins Play a Key Role in Stress Erythropoiesis by Regulating both the Stress Erythroid Progenitors and the Spleen Microenvironment"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmBrian Dulmovits (Hofstra Northwell School of Medicine, USA)
"HMGB1 Acts as a Causative Factor of Erythropoietin-Refractory Anemia Associated with Inflammation"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmRuopeng Feng (St. Jude Children's Research Hospital, USA)
"A CRISPR/Cas9 gRNA Library Screen Identifies UHRF1 as a Potential Modulator of HbF Production"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmMargaux Chauvet (UMR 216, Institut de Recherche pour le Développement (IRD), Université Paris Descartes, France)
"Differential Phosphorylation of Human Erythrocyte Proteins According to Haemoglobin S and C Carriage upon Infection by Plasmodium falciparum"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number R13DK113765. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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