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Red Cells (GRS)
Gordon Research Seminar

Exploring Transcriptional, Metabolic and Structural Mechanisms in Red Cell Biology and Disease

Dates

July 15-16, 2017

Location

Salve Regina University
Newport, RI Site Information

Organizers

Chairs:
Marlies P. Rossmann & Daniel Hidalgo

Application Deadline

The application deadline for this meeting was June 17, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

Overview

The Gordon Research Seminar on Red Cells is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas prior to the full Gordon Research Conference at the same venue.

The scientific focus of this meeting covers the entire spectrum of red cell biology, from the transcriptional regulation of erythropoiesis to the structure, metabolism and function of red cells, and red cell diseases. The Red Cells GRS gives attendees the chance to discuss both their current research and future career options with their peers and senior scientists in the field.

Application Instructions

The meeting will feature approximately 10 talks and 2 poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral presentation or presenting a poster. Therefore, all applications must include an abstract.

The Chairs will select speakers from abstracts submitted by April 15, 2017. Those applicants who are not chosen for talks and those who apply after the deadline to be considered for an oral presentation will be expected to present a poster. In order to participate, you must submit an application by the date indicated in the Application Deadline section above.

Related Meeting

This GRS will be held in conjunction with the "Red Cells" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: About Stem Cells and Red Cells: Two Perspectives
Discussion Leader: Daniel Hidalgo (University of Massachusetts Medical School, USA)
3:45 pm - 4:05 pmJames Palis (University of Rochester Medical Center, USA)
"A Developmental Journey"
4:05 pm - 4:15 pmDiscussion
4:15 pm - 4:30 pmGeneral Discussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: About Stem Cells and Red Cells: Two Perspectives (continued) / Understanding Red Cell Formation from Different Angles
Discussion Leaders: Alyson Smith (The Scripps Research Institute, USA) and Debora Stefanova (University of California, Los Angeles, USA)
7:30 pm - 7:50 pmElaine Dzierzak (Erasmus University Medical Center, The Netherlands)
"Crossing Borders of Professional, Personal and Stem Cell Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmAnnamaria Aprile (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Italy)
"Beta-Thalassemia Beyond the Erythropoietic Defect: Impaired Self-Renewal of Hematopoietic Stem Cell Within an Altered Bone Marrow Niche"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmJayme Olsen (University of Rochester, USA)
"Bmi-1 Overexpression Increases Ex Vivo Self-Renewal of Human Erythroblasts"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmAishwarya Swaminathan (University of Massachusetts Medical School, USA)
"Analyzing the Effect of Acute Deletion of Tet2 and Tet3 Dioxygenases on Erythropoiesis"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSteven Heshusius (Sanquin, The Netherlands)
"Fetal Hemoglobin Expression in Adult Erythroid Cultures Is Repressed by Signaling Activated by CD14+ Cells"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmShuping Zhang (Massachusetts Institute of Technology, USA)
"Genome-Wide Heme and eIF2aP Regulated Gene Expression in Basophilic Erythroblasts"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmAndra Dumitru (Université Catholique de Louvain, Belgium)
"Investigation at High-Resolution of Red Blood Cells Plasma Membrane Lipid Microdomains"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amMentorship Component: Career Panel / Transcriptional and Epigenetic Regulation of Erythropoiesis
The career panel consists of a diverse group of panelists, covering the spectrum of academic science at different career stages, geographic locations and type of institutions as well as alternative careers in the life sciences. Each panelist will give a brief introduction about their career path followed by a Q&A session moderated by the GRS Conference Chairs.
Discussion Leaders: Marlies Rossmann (Harvard University, USA), Mary Lee (University of Michigan Medical School, USA) and Alejandra Macias (Massachusetts Institute of Technology, USA)
9:00 am - 10:00 amPanel Discussion
"Career Development"
  • Terry Bishop (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
  • Elaine Dzierzak (Erasmus University Medical Center, The Netherlands)
  • James Palis (University of Rochester Medical Center, USA)
  • Jeff Shearstone (Acetylon Pharmaceuticals, USA)
  • Deborah Sweet (Cell Stem Cell, Cell Press, USA)
  • Mitchell Weiss (St. Jude Children's Research Hospital, USA)
  • Jian Xu (University of Texas Southwestern Medical Center, USA)
10:00 am - 10:10 amElisabeth Heuston (National Human Genome Research Institute, NIH, USA)
"Erythropoiesis Requires Epigenetic and Transcriptional Reprogramming to Divert Hematopoietic Stem and Progenitor Cells from Pre-Primed Megakaryocytic Fate"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amAvik Choudhuri (Harvard University, USA)
"Signaling Centers Define Stages of Human Erythropoiesis and Harbor Common Variants of Red Blood Cell Traits"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amKyle Hewitt (University of Wisconsin-Madison, USA)
"GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amChang Liao (Pennsylvania State University, USA)
"Selenoproteins Play a Key Role in Stress Erythropoiesis by Regulating Both the Stress Erythroid Progenitors and the Spleen Microenvironment"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmRed Cell Disorders and Therapies
Discussion Leaders: Yuanting Chen (Pennsylvania State University, USA) and Giulia Pavani (Genethon, France)
1:30 pm - 1:40 pmBrian Dulmovits (Hofstra Northwell School of Medicine, USA)
"HMGB1 Acts as a Causative Factor of Erythropoietin-Refractory Anemia Associated with Inflammation"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmRhogerry Deshycka (Whitehead Institute for Biomedical Research, USA)
"Engineered Red Blood Cells Carrying PCSK9 Inhibitors as Cholesterol Blockbuster"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmMargaux Chauvet (UMR 216, Institut de Recherche pour le Développement (IRD), Université Paris Descartes, France)
"Differential Phosphorylation of Human Erythrocyte Proteins According to Haemoglobin S and C Carriage upon Infection by Plasmodium falciparum"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmJoshua Denny (University of Louisville, USA)
"Crosstalk Between the Gut Microbiota and Blood Stage Malaria"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Institute of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health under Award Number R13DK113765. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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